Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample
Abstract Introduction Clinically significant pericardial effusions and cardiac tamponade in systemic sclerosis (SSc) patients is uncommon and the factors that contribute to progression of pericardial involvement in SSc patients have not been well established. Methods A review of the national inpatie...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Rheumatology |
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| Online Access: | https://doi.org/10.1186/s41927-023-00360-9 |
| _version_ | 1827632792299634688 |
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| author | Bikash Basyal Waqas Ullah Chris T. Derk |
| author_facet | Bikash Basyal Waqas Ullah Chris T. Derk |
| author_sort | Bikash Basyal |
| collection | DOAJ |
| description | Abstract Introduction Clinically significant pericardial effusions and cardiac tamponade in systemic sclerosis (SSc) patients is uncommon and the factors that contribute to progression of pericardial involvement in SSc patients have not been well established. Methods A review of the national inpatient sample database was performed looking SSc related hospitalizations between 2002 and 2019. Data was collected on patients with pericardial effusions and cardiac tamponade and analyzed to identify and describe patient characteristics and comorbidities. Results Out of a total of 523,410 SSc hospitalizations, with an overall inpatient mortality rate of 4.7% (24,764 patients), pericardial effusion was identified in 3.1% of all hospitalizations (16,141 patients) out of which 0.2% (838 patients) had a diagnosis of cardiac tamponade. Patients with pericardial effusion were significantly more likely to have pulmonary circulatory disease (p = < 0.0001), congestive heart failure (p = < 0.0001) end stage renal disease (p = < 0.0001), diabetes (p = 0.015), and hypothyroidism (p = 0.025). Patients with cardiac tamponade were significantly more likely to have a history of coronary artery bypass graft surgery (p = 0.001) or atrial fibrillation (p = < 0.0001). Hospitalized patients with cardiac tamponade had a significantly increased mortality rate of 17.7% compared to 8.8% in patients with pericardial effusions without a tamponade physiology, with an odds ratio of 2.3 (1.97–2.86), p = < 0.0001. Conclusion Pericardial effusion and tamponade are associated with increased morbidity and mortality in SSc patients. Further studies are required to explore the role of patient comorbidities and characteristics in development into pericardial effusions or tamponade. |
| first_indexed | 2024-03-09T14:49:33Z |
| format | Article |
| id | doaj.art-a044b9a54d434459a1256f6f28735175 |
| institution | Directory Open Access Journal |
| issn | 2520-1026 |
| language | English |
| last_indexed | 2024-03-09T14:49:33Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj.art-a044b9a54d434459a1256f6f287351752023-11-26T14:32:22ZengBMCBMC Rheumatology2520-10262023-09-01711510.1186/s41927-023-00360-9Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sampleBikash Basyal0Waqas Ullah1Chris T. Derk2Department of Medicine, Jefferson Abington HospitalDivision of Cardiology, Thomas Jefferson University HospitalDivision of Rheumatology, University of PennsylvaniaAbstract Introduction Clinically significant pericardial effusions and cardiac tamponade in systemic sclerosis (SSc) patients is uncommon and the factors that contribute to progression of pericardial involvement in SSc patients have not been well established. Methods A review of the national inpatient sample database was performed looking SSc related hospitalizations between 2002 and 2019. Data was collected on patients with pericardial effusions and cardiac tamponade and analyzed to identify and describe patient characteristics and comorbidities. Results Out of a total of 523,410 SSc hospitalizations, with an overall inpatient mortality rate of 4.7% (24,764 patients), pericardial effusion was identified in 3.1% of all hospitalizations (16,141 patients) out of which 0.2% (838 patients) had a diagnosis of cardiac tamponade. Patients with pericardial effusion were significantly more likely to have pulmonary circulatory disease (p = < 0.0001), congestive heart failure (p = < 0.0001) end stage renal disease (p = < 0.0001), diabetes (p = 0.015), and hypothyroidism (p = 0.025). Patients with cardiac tamponade were significantly more likely to have a history of coronary artery bypass graft surgery (p = 0.001) or atrial fibrillation (p = < 0.0001). Hospitalized patients with cardiac tamponade had a significantly increased mortality rate of 17.7% compared to 8.8% in patients with pericardial effusions without a tamponade physiology, with an odds ratio of 2.3 (1.97–2.86), p = < 0.0001. Conclusion Pericardial effusion and tamponade are associated with increased morbidity and mortality in SSc patients. Further studies are required to explore the role of patient comorbidities and characteristics in development into pericardial effusions or tamponade.https://doi.org/10.1186/s41927-023-00360-9Systemic sclerosisSclerodermaCardiacPericardial effusionTamponade |
| spellingShingle | Bikash Basyal Waqas Ullah Chris T. Derk Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample BMC Rheumatology Systemic sclerosis Scleroderma Cardiac Pericardial effusion Tamponade |
| title | Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample |
| title_full | Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample |
| title_fullStr | Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample |
| title_full_unstemmed | Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample |
| title_short | Pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients: analysis of the national inpatient sample |
| title_sort | pericardial effusions and cardiac tamponade in hospitalized systemic sclerosis patients analysis of the national inpatient sample |
| topic | Systemic sclerosis Scleroderma Cardiac Pericardial effusion Tamponade |
| url | https://doi.org/10.1186/s41927-023-00360-9 |
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