Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents
Background: Behaviourally HIV-infected adolescent females are at higher risk for abnormal cervical cytology and HPV infection compared to those who are uninfected, but data on perinatally HIV-infected adolescent females are lacking. Methods: Cervical cytology, HPV infection and E6/E7 mRNA were asses...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Journal of Virus Eradication |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2055664020311468 |
| _version_ | 1818598431647596544 |
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| author | J. Ananworanich W. Prasitsuebsai S.J. Kerr R. Hansudewechakul N. Teeratakulpisarn K. Saisawat R. Ramautarsing J. Achalapong K. Pussadee S. Keadpudsa T. Mackay T. Pankam P. Rodbamrung W. Petdachai K. Chokephaibulkit A.H. Sohn N. Phanuphak |
| author_facet | J. Ananworanich W. Prasitsuebsai S.J. Kerr R. Hansudewechakul N. Teeratakulpisarn K. Saisawat R. Ramautarsing J. Achalapong K. Pussadee S. Keadpudsa T. Mackay T. Pankam P. Rodbamrung W. Petdachai K. Chokephaibulkit A.H. Sohn N. Phanuphak |
| author_sort | J. Ananworanich |
| collection | DOAJ |
| description | Background: Behaviourally HIV-infected adolescent females are at higher risk for abnormal cervical cytology and HPV infection compared to those who are uninfected, but data on perinatally HIV-infected adolescent females are lacking. Methods: Cervical cytology, HPV infection and E6/E7 mRNA were assessed in sexually active 12–24-year-old adolescent females: perinatally HIV-infected (group 1, n=40), behaviourally HIV-infected (group 2, n=10), and HIV-uninfected (group 3, n=10). Results: Median age was lower in group 1 (18 years) than in groups 2 (24 years) and 3 (20.5 years) (P<0.001), and median time since sexual debut was shorter: 2 vs 5 vs 4 years (P<0.001). More trial participants in group 1 than group 2 were on antiretrovirals (90% vs 70%; P<0.001). Abnormal cervical cytology (atypical squamous cells of undetermined significance and higher) was observed in 30% (group 1), 40% (group 2) and 30% (group 3) (P=0.92), whereas high-risk HPV infection was observed in 45%, 45% and 40%, respectively (P=1.00). Positive E6/E7 mRNA was found in 28% of group 1, but not in other groups. High-risk HPV infection predicted abnormal cytology in all groups [OR 6.77, 95% confidence interval (CI) 1.99–23.0; P=0.001). Additionally, plasma HIV RNA ≥50 copies/mL (OR 13.3, 95% CI 1.16–153.06; P=0.04) predicted abnormal cytology in HIV-infected adolescent females. Conclusions: Despite the younger age and shorter time since sexual debut, cervical cytological abnormalities and HPV infection were as common in perinatally HIV-infected as in behaviourally infected and uninfected adolescents. HPV vaccination, pre-cancer screening and antiretroviral treatment in HIV-infected female adolescents should be implemented to minimise the risk of cervical cancer. |
| first_indexed | 2024-12-16T12:03:36Z |
| format | Article |
| id | doaj.art-a047077c6b034efe93b7b7edef4b6ace |
| institution | Directory Open Access Journal |
| issn | 2055-6640 |
| language | English |
| last_indexed | 2024-12-16T12:03:36Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Virus Eradication |
| spelling | doaj.art-a047077c6b034efe93b7b7edef4b6ace2022-12-21T22:32:22ZengElsevierJournal of Virus Eradication2055-66402015-01-01113037Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescentsJ. Ananworanich0W. Prasitsuebsai1S.J. Kerr2R. Hansudewechakul3N. Teeratakulpisarn4K. Saisawat5R. Ramautarsing6J. Achalapong7K. Pussadee8S. Keadpudsa9T. Mackay10T. Pankam11P. Rodbamrung12W. Petdachai13K. Chokephaibulkit14A.H. Sohn15N. Phanuphak16Corresponding author: Jintanat Ananworanich, US Military HIV Research Program, 6720A Rockledge Drive, Suite 400, Rockville, MD, 20817, USA; HIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Thai Red Cross AIDS Research Centre, Bangkok, Thailand; SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Present address: US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MDHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Thai Red Cross AIDS Research Centre, Bangkok, ThailandHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Kirby Institute of Infection and Immunity in Society, University of New South Wales, Sydney, AustraliaChiangrai Prachanukroh Hospital, Chiangrai, ThailandThai Red Cross AIDS Research Centre, Bangkok, ThailandChiangrai Prachanukroh Hospital, Chiangrai, ThailandHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam, the NetherlandsChiangrai Prachanukroh Hospital, Chiangrai, ThailandHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Thai Red Cross AIDS Research Centre, Bangkok, ThailandHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Thai Red Cross AIDS Research Centre, Bangkok, ThailandHIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand; Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam, the NetherlandsThai Red Cross AIDS Research Centre, Bangkok, ThailandThai Red Cross AIDS Research Centre, Bangkok, ThailandPetchburi Hospital, Petchburi, ThailandFaculty of Medicine, Siriraj Hosptial, Mahidol University, Bangkok, ThailandTREAT Asia/amfAR – The Foundation for AIDS Research, Bangkok, ThailandThai Red Cross AIDS Research Centre, Bangkok, Thailand; SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, ThailandBackground: Behaviourally HIV-infected adolescent females are at higher risk for abnormal cervical cytology and HPV infection compared to those who are uninfected, but data on perinatally HIV-infected adolescent females are lacking. Methods: Cervical cytology, HPV infection and E6/E7 mRNA were assessed in sexually active 12–24-year-old adolescent females: perinatally HIV-infected (group 1, n=40), behaviourally HIV-infected (group 2, n=10), and HIV-uninfected (group 3, n=10). Results: Median age was lower in group 1 (18 years) than in groups 2 (24 years) and 3 (20.5 years) (P<0.001), and median time since sexual debut was shorter: 2 vs 5 vs 4 years (P<0.001). More trial participants in group 1 than group 2 were on antiretrovirals (90% vs 70%; P<0.001). Abnormal cervical cytology (atypical squamous cells of undetermined significance and higher) was observed in 30% (group 1), 40% (group 2) and 30% (group 3) (P=0.92), whereas high-risk HPV infection was observed in 45%, 45% and 40%, respectively (P=1.00). Positive E6/E7 mRNA was found in 28% of group 1, but not in other groups. High-risk HPV infection predicted abnormal cytology in all groups [OR 6.77, 95% confidence interval (CI) 1.99–23.0; P=0.001). Additionally, plasma HIV RNA ≥50 copies/mL (OR 13.3, 95% CI 1.16–153.06; P=0.04) predicted abnormal cytology in HIV-infected adolescent females. Conclusions: Despite the younger age and shorter time since sexual debut, cervical cytological abnormalities and HPV infection were as common in perinatally HIV-infected as in behaviourally infected and uninfected adolescents. HPV vaccination, pre-cancer screening and antiretroviral treatment in HIV-infected female adolescents should be implemented to minimise the risk of cervical cancer.http://www.sciencedirect.com/science/article/pii/S2055664020311468perinatal HIVHPVcervixadolescentsPap smear |
| spellingShingle | J. Ananworanich W. Prasitsuebsai S.J. Kerr R. Hansudewechakul N. Teeratakulpisarn K. Saisawat R. Ramautarsing J. Achalapong K. Pussadee S. Keadpudsa T. Mackay T. Pankam P. Rodbamrung W. Petdachai K. Chokephaibulkit A.H. Sohn N. Phanuphak Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents Journal of Virus Eradication perinatal HIV HPV cervix adolescents Pap smear |
| title | Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents |
| title_full | Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents |
| title_fullStr | Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents |
| title_full_unstemmed | Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents |
| title_short | Cervical cytological abnormalities and HPV infection in perinatally HIV–infected adolescents |
| title_sort | cervical cytological abnormalities and hpv infection in perinatally hiv infected adolescents |
| topic | perinatal HIV HPV cervix adolescents Pap smear |
| url | http://www.sciencedirect.com/science/article/pii/S2055664020311468 |
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