Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniophary...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01992-5 |
| _version_ | 1818422834600345600 |
|---|---|
| author | Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera |
| author_facet | Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera |
| author_sort | Jose Mario Gonzalez-Meljem |
| collection | DOAJ |
| description | Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma. |
| first_indexed | 2024-12-14T13:32:33Z |
| format | Article |
| id | doaj.art-a0474958863a4634a3e1c6faf8951dc5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:32:33Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a0474958863a4634a3e1c6faf8951dc52022-12-21T22:59:40ZengNature PortfolioNature Communications2041-17232017-11-018111410.1038/s41467-017-01992-5Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngiomaJose Mario Gonzalez-Meljem0Scott Haston1Gabriela Carreno2John R. Apps3Sara Pozzi4Christina Stache5Grace Kaushal6Alex Virasami7Leonidas Panousopoulos8Seyedeh Neda Mousavy-Gharavy9Ana Guerrero10Mamunur Rashid11Nital Jani12Colin R. Goding13Thomas S. Jacques14David J. Adams15Jesus Gil16Cynthia L. Andoniadou17Juan Pedro Martinez-Barbera18Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDepartment of Histopathology, Great Ormond Street Hospital for ChildrenDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthCell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane RoadExperimental Cancer Genetics, Wellcome Trust Sanger Institute, HinxtonGOSgene, Genetics and Genomic Medicine, UCL Institute of Child HealthLudwig Institute for Cancer Research, Oxford University, Old Road Campus, HeadingtonDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthExperimental Cancer Genetics, Wellcome Trust Sanger Institute, HinxtonCell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane RoadCentre for Craniofacial and Regenerative Biology, King’s College London, Guy’s Hospital, Floor 27 Tower WingDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child HealthSenescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.https://doi.org/10.1038/s41467-017-01992-5 |
| spellingShingle | Jose Mario Gonzalez-Meljem Scott Haston Gabriela Carreno John R. Apps Sara Pozzi Christina Stache Grace Kaushal Alex Virasami Leonidas Panousopoulos Seyedeh Neda Mousavy-Gharavy Ana Guerrero Mamunur Rashid Nital Jani Colin R. Goding Thomas S. Jacques David J. Adams Jesus Gil Cynthia L. Andoniadou Juan Pedro Martinez-Barbera Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma Nature Communications |
| title | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| title_full | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| title_fullStr | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| title_full_unstemmed | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| title_short | Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| title_sort | stem cell senescence drives age attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma |
| url | https://doi.org/10.1038/s41467-017-01992-5 |
| work_keys_str_mv | AT josemariogonzalezmeljem stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT scotthaston stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT gabrielacarreno stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT johnrapps stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT sarapozzi stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT christinastache stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT gracekaushal stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT alexvirasami stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT leonidaspanousopoulos stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT seyedehnedamousavygharavy stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT anaguerrero stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT mamunurrashid stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT nitaljani stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT colinrgoding stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT thomassjacques stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT davidjadams stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT jesusgil stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT cynthialandoniadou stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma AT juanpedromartinezbarbera stemcellsenescencedrivesageattenuatedinductionofpituitarytumoursinmousemodelsofpaediatriccraniopharyngioma |