5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome
<i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) is a common bacterial colonizer on the surface of human skin. <i>Lactate</i> is a natural constituent of skin. Here, we reveal that <i>S. epidermidis</i> used sodium <span style="font-va...
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| Format: | Article |
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MDPI AG
2019-08-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/7/8/239 |
| _version_ | 1819098094052048896 |
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| author | Manish Kumar Binderiya Myagmardoloonjin Sunita Keshari Indira Putri Negari Chun-Ming Huang |
| author_facet | Manish Kumar Binderiya Myagmardoloonjin Sunita Keshari Indira Putri Negari Chun-Ming Huang |
| author_sort | Manish Kumar |
| collection | DOAJ |
| description | <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) is a common bacterial colonizer on the surface of human skin. <i>Lactate</i> is a natural constituent of skin. Here, we reveal that <i>S. epidermidis</i> used sodium <span style="font-variant: small-caps;">l</span>-lactate as a carbon source to undergo fermentation and yield malodors detected by gas colorimetric tubes. Several furan compounds such as furfural originating from the fermentation metabolites play a role in the negative feedback regulation of the fermentation process. The 5-methyl furfural (5MF), a furfural analog, was selected as an inhibitor of sodium <span style="font-variant: small-caps;">l</span>-lactate fermentation of <i>S. epidermidis</i> via inhibition of acetolactate synthase (ALS). <i>S. epidermidis</i> treated with 5MF lost its ability to produce malodors, demonstrating the feasibility of using 5MF as an ingredient in deodorants targeting malodor-causing bacteria in the skin microbiome. |
| first_indexed | 2024-12-22T00:25:31Z |
| format | Article |
| id | doaj.art-a047821e4698481ea23fe47b23c23dea |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-22T00:25:31Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-a047821e4698481ea23fe47b23c23dea2022-12-21T18:45:03ZengMDPI AGMicroorganisms2076-26072019-08-017823910.3390/microorganisms7080239microorganisms70802395-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin MicrobiomeManish Kumar0Binderiya Myagmardoloonjin1Sunita Keshari2Indira Putri Negari3Chun-Ming Huang4Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 320009, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320009, TaiwanDepartment of Life Sciences, National Central University, Taoyuan 320009, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320009, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 320009, Taiwan<i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) is a common bacterial colonizer on the surface of human skin. <i>Lactate</i> is a natural constituent of skin. Here, we reveal that <i>S. epidermidis</i> used sodium <span style="font-variant: small-caps;">l</span>-lactate as a carbon source to undergo fermentation and yield malodors detected by gas colorimetric tubes. Several furan compounds such as furfural originating from the fermentation metabolites play a role in the negative feedback regulation of the fermentation process. The 5-methyl furfural (5MF), a furfural analog, was selected as an inhibitor of sodium <span style="font-variant: small-caps;">l</span>-lactate fermentation of <i>S. epidermidis</i> via inhibition of acetolactate synthase (ALS). <i>S. epidermidis</i> treated with 5MF lost its ability to produce malodors, demonstrating the feasibility of using 5MF as an ingredient in deodorants targeting malodor-causing bacteria in the skin microbiome.https://www.mdpi.com/2076-2607/7/8/239deodorantsdiacetyl5-methylfurfuralmicrobiome<i>Staphylococcus epidermidis</i> |
| spellingShingle | Manish Kumar Binderiya Myagmardoloonjin Sunita Keshari Indira Putri Negari Chun-Ming Huang 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome Microorganisms deodorants diacetyl 5-methylfurfural microbiome <i>Staphylococcus epidermidis</i> |
| title | 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome |
| title_full | 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome |
| title_fullStr | 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome |
| title_full_unstemmed | 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome |
| title_short | 5-Methyl Furfural Reduces the Production of Malodors by Inhibiting Sodium l-Lactate Fermentation of <em>Staphylococcus epidermidis</em>: Implication for Deodorants Targeting the Fermenting Skin Microbiome |
| title_sort | 5 methyl furfural reduces the production of malodors by inhibiting sodium l lactate fermentation of em staphylococcus epidermidis em implication for deodorants targeting the fermenting skin microbiome |
| topic | deodorants diacetyl 5-methylfurfural microbiome <i>Staphylococcus epidermidis</i> |
| url | https://www.mdpi.com/2076-2607/7/8/239 |
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