The potential roles of dental pulp stem cells in peripheral nerve regeneration
Peripheral nerve diseases are significantly correlated with severe fractures or trauma and surgeries, leading to poor life quality and impairment of physical and mental health. Human dental pulp stem cells (DPSCs) are neural crest stem cells with a strong multi-directional differentiation potential...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1098857/full |
| _version_ | 1797955983838806016 |
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| author | Jing Fu Xigong Li Feilu Jin Yanzhao Dong Haiying Zhou Ahmad Alhaskawi Zewei Wang Jingtian Lai Chengjun Yao Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Bin Chen Hui Lu Hui Lu |
| author_facet | Jing Fu Xigong Li Feilu Jin Yanzhao Dong Haiying Zhou Ahmad Alhaskawi Zewei Wang Jingtian Lai Chengjun Yao Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Bin Chen Hui Lu Hui Lu |
| author_sort | Jing Fu |
| collection | DOAJ |
| description | Peripheral nerve diseases are significantly correlated with severe fractures or trauma and surgeries, leading to poor life quality and impairment of physical and mental health. Human dental pulp stem cells (DPSCs) are neural crest stem cells with a strong multi-directional differentiation potential and proliferation capacity that provide a novel cell source for nerve regeneration. DPSCs are easily extracted from dental pulp tissue of human permanent or deciduous teeth. DPSCs can express neurotrophic and immunomodulatory factors and, subsequently, induce blood vessel formation and nerve regeneration. Therefore, DPSCs yield valuable therapeutic potential in the management of peripheral neuropathies. With the purpose of summarizing the advances in DPSCs and their potential applications in peripheral neuropathies, this article reviews the biological characteristics of DPSCs in association with the mechanisms of peripheral nerve regeneration. |
| first_indexed | 2024-04-10T23:41:41Z |
| format | Article |
| id | doaj.art-a047aed2e8d5482792b19ac6a822c2a8 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T23:41:41Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-a047aed2e8d5482792b19ac6a822c2a82023-01-11T06:54:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011310.3389/fneur.2022.10988571098857The potential roles of dental pulp stem cells in peripheral nerve regenerationJing Fu0Xigong Li1Feilu Jin2Yanzhao Dong3Haiying Zhou4Ahmad Alhaskawi5Zewei Wang6Jingtian Lai7Chengjun Yao8Sohaib Hasan Abdullah Ezzi9Vishnu Goutham Kota10Mohamed Hasan Abdulla Hasan Abdulla11Bin Chen12Hui Lu13Hui Lu14Department of Stomatology, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaOral and Maxillofacial Surgery Department, The Second Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaZhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, Third Xiangya Hospital, Central South University, Changsha, Hunan, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaDepartment of Orthopedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, ChinaAlibaba-Zhejiang University Joint Research Center of Future Digital Healthcare, Zhejiang University, Hangzhou, Zhejiang, ChinaPeripheral nerve diseases are significantly correlated with severe fractures or trauma and surgeries, leading to poor life quality and impairment of physical and mental health. Human dental pulp stem cells (DPSCs) are neural crest stem cells with a strong multi-directional differentiation potential and proliferation capacity that provide a novel cell source for nerve regeneration. DPSCs are easily extracted from dental pulp tissue of human permanent or deciduous teeth. DPSCs can express neurotrophic and immunomodulatory factors and, subsequently, induce blood vessel formation and nerve regeneration. Therefore, DPSCs yield valuable therapeutic potential in the management of peripheral neuropathies. With the purpose of summarizing the advances in DPSCs and their potential applications in peripheral neuropathies, this article reviews the biological characteristics of DPSCs in association with the mechanisms of peripheral nerve regeneration.https://www.frontiersin.org/articles/10.3389/fneur.2022.1098857/fulldental pulp stem cellsneuronSchwann cellsperipheral nerve diseasesneurotrophic factors |
| spellingShingle | Jing Fu Xigong Li Feilu Jin Yanzhao Dong Haiying Zhou Ahmad Alhaskawi Zewei Wang Jingtian Lai Chengjun Yao Sohaib Hasan Abdullah Ezzi Vishnu Goutham Kota Mohamed Hasan Abdulla Hasan Abdulla Bin Chen Hui Lu Hui Lu The potential roles of dental pulp stem cells in peripheral nerve regeneration Frontiers in Neurology dental pulp stem cells neuron Schwann cells peripheral nerve diseases neurotrophic factors |
| title | The potential roles of dental pulp stem cells in peripheral nerve regeneration |
| title_full | The potential roles of dental pulp stem cells in peripheral nerve regeneration |
| title_fullStr | The potential roles of dental pulp stem cells in peripheral nerve regeneration |
| title_full_unstemmed | The potential roles of dental pulp stem cells in peripheral nerve regeneration |
| title_short | The potential roles of dental pulp stem cells in peripheral nerve regeneration |
| title_sort | potential roles of dental pulp stem cells in peripheral nerve regeneration |
| topic | dental pulp stem cells neuron Schwann cells peripheral nerve diseases neurotrophic factors |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1098857/full |
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