The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases
The eukaryotic translation elongation factors (EEFs), i.e. EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step of translation but are often altered in cancer. Less investigated are their pseudogenes. Recently, it was demonstrated th...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-07-01
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| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304221000489 |
| _version_ | 1797756656079077376 |
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| author | Luigi Cristiano |
| author_facet | Luigi Cristiano |
| author_sort | Luigi Cristiano |
| collection | DOAJ |
| description | The eukaryotic translation elongation factors (EEFs), i.e. EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step of translation but are often altered in cancer. Less investigated are their pseudogenes. Recently, it was demonstrated that pseudogenes have a key regulatory role in the cell, especially via non-coding RNAs, and that the aberrant expression of ncRNAs has an important role in cancer development and progression. The present review paper, for the first time, collects all that published about the EEFs pseudogenes to create a base for future investigations. For most of them, the studies are in their infancy, while for others the studies suggest their involvement in normal cell physiology but also in various human diseases. However, more investigations are needed to understand their functions in both normal and cancer cells and to define which can be useful biomarkers or therapeutic targets. |
| first_indexed | 2024-03-12T18:04:38Z |
| format | Article |
| id | doaj.art-a048808a46d24692bcd8d0e591758ef6 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T18:04:38Z |
| publishDate | 2022-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-a048808a46d24692bcd8d0e591758ef62023-08-02T09:32:05ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-07-0194941958The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseasesLuigi Cristiano0R&D Division, Prestige, 18 via Vecchia, Terranuova Bracciolini, AR 52028, ItalyThe eukaryotic translation elongation factors (EEFs), i.e. EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF1E1 and EEF2, are coding-genes that play a central role in the elongation step of translation but are often altered in cancer. Less investigated are their pseudogenes. Recently, it was demonstrated that pseudogenes have a key regulatory role in the cell, especially via non-coding RNAs, and that the aberrant expression of ncRNAs has an important role in cancer development and progression. The present review paper, for the first time, collects all that published about the EEFs pseudogenes to create a base for future investigations. For most of them, the studies are in their infancy, while for others the studies suggest their involvement in normal cell physiology but also in various human diseases. However, more investigations are needed to understand their functions in both normal and cancer cells and to define which can be useful biomarkers or therapeutic targets.http://www.sciencedirect.com/science/article/pii/S2352304221000489CancerEEFsNon-coding RNAPseudogeneTranslationTranslation elongation factor |
| spellingShingle | Luigi Cristiano The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases Genes and Diseases Cancer EEFs Non-coding RNA Pseudogene Translation Translation elongation factor |
| title | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases |
| title_full | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases |
| title_fullStr | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases |
| title_full_unstemmed | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases |
| title_short | The pseudogenes of eukaryotic translation elongation factors (EEFs): Role in cancer and other human diseases |
| title_sort | pseudogenes of eukaryotic translation elongation factors eefs role in cancer and other human diseases |
| topic | Cancer EEFs Non-coding RNA Pseudogene Translation Translation elongation factor |
| url | http://www.sciencedirect.com/science/article/pii/S2352304221000489 |
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