Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes
Aurachins are farnesylated quinolone alkaloids of bacterial origin and excellent inhibitors of the respiratory chain in pro- and eukaryotes. Therefore, they have become important tool compounds for the investigation of electron transport processes and they also serve as lead structures for the devel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/6/1067 |
| _version_ | 1827738923082711040 |
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| author | Sebastian Kruth Markus Nett |
| author_facet | Sebastian Kruth Markus Nett |
| author_sort | Sebastian Kruth |
| collection | DOAJ |
| description | Aurachins are farnesylated quinolone alkaloids of bacterial origin and excellent inhibitors of the respiratory chain in pro- and eukaryotes. Therefore, they have become important tool compounds for the investigation of electron transport processes and they also serve as lead structures for the development of antibacterial and antiprotozoal drugs. Especially aurachin D proved to be a valuable starting point for structure-activity relationship studies. Aurachin D is a selective inhibitor of the cytochrome <i>bd</i> oxidase, which has received increasing attention as a target for the treatment of infectious diseases caused by mycobacteria. Moreover, aurachin D possesses remarkable activities against <i>Leishmania donovani</i>, the causative agent of leishmaniasis. Aurachins are naturally produced by myxobacteria of the genus <i>Stigmatella</i> as well as by some <i>Streptomyces</i> and <i>Rhodococcus</i> strains. The recombinant production of these antibiotics turned out to be challenging due to their complex biosynthesis and their inherent toxicity. Recently, the biotechnological production of aurachin D was established in <i>E. coli</i> with a titer which is higher than previously reported from natural producer organisms. |
| first_indexed | 2024-03-11T02:50:52Z |
| format | Article |
| id | doaj.art-a048b36e2812474690e2bbdeb16e077e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T02:50:52Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-a048b36e2812474690e2bbdeb16e077e2023-11-18T09:01:35ZengMDPI AGAntibiotics2079-63822023-06-01126106710.3390/antibiotics12061067Aurachins, Bacterial Antibiotics Interfering with Electron Transport ProcessesSebastian Kruth0Markus Nett1Laboratory of Technical Biology, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyLaboratory of Technical Biology, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyAurachins are farnesylated quinolone alkaloids of bacterial origin and excellent inhibitors of the respiratory chain in pro- and eukaryotes. Therefore, they have become important tool compounds for the investigation of electron transport processes and they also serve as lead structures for the development of antibacterial and antiprotozoal drugs. Especially aurachin D proved to be a valuable starting point for structure-activity relationship studies. Aurachin D is a selective inhibitor of the cytochrome <i>bd</i> oxidase, which has received increasing attention as a target for the treatment of infectious diseases caused by mycobacteria. Moreover, aurachin D possesses remarkable activities against <i>Leishmania donovani</i>, the causative agent of leishmaniasis. Aurachins are naturally produced by myxobacteria of the genus <i>Stigmatella</i> as well as by some <i>Streptomyces</i> and <i>Rhodococcus</i> strains. The recombinant production of these antibiotics turned out to be challenging due to their complex biosynthesis and their inherent toxicity. Recently, the biotechnological production of aurachin D was established in <i>E. coli</i> with a titer which is higher than previously reported from natural producer organisms.https://www.mdpi.com/2079-6382/12/6/1067aurachinquinolone antibioticsantibacterialantiprotozoalrespiratory chaincytochrome <i>bd</i> |
| spellingShingle | Sebastian Kruth Markus Nett Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes Antibiotics aurachin quinolone antibiotics antibacterial antiprotozoal respiratory chain cytochrome <i>bd</i> |
| title | Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes |
| title_full | Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes |
| title_fullStr | Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes |
| title_full_unstemmed | Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes |
| title_short | Aurachins, Bacterial Antibiotics Interfering with Electron Transport Processes |
| title_sort | aurachins bacterial antibiotics interfering with electron transport processes |
| topic | aurachin quinolone antibiotics antibacterial antiprotozoal respiratory chain cytochrome <i>bd</i> |
| url | https://www.mdpi.com/2079-6382/12/6/1067 |
| work_keys_str_mv | AT sebastiankruth aurachinsbacterialantibioticsinterferingwithelectrontransportprocesses AT markusnett aurachinsbacterialantibioticsinterferingwithelectrontransportprocesses |