Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases
Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose me...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2012-06-01
|
| Series: | Balkan Medical Journal |
| Subjects: | |
| Online Access: | http://balkanmedicaljournal.org/text.php3?id=868 |
| _version_ | 1797908898703736832 |
|---|---|
| author | Cumali Gökçe Esin Atik Mehmet Uğur İnan Asena Çiğdem Doğramacı |
| author_facet | Cumali Gökçe Esin Atik Mehmet Uğur İnan Asena Çiğdem Doğramacı |
| author_sort | Cumali Gökçe |
| collection | DOAJ |
| description | Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy. |
| first_indexed | 2024-04-10T11:00:08Z |
| format | Article |
| id | doaj.art-a048d95458104981a5f403b87b317d35 |
| institution | Directory Open Access Journal |
| issn | 2146-3123 2146-3131 |
| language | English |
| last_indexed | 2024-04-10T11:00:08Z |
| publishDate | 2012-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Balkan Medical Journal |
| spelling | doaj.art-a048d95458104981a5f403b87b317d352023-02-15T16:19:43ZengGalenos Publishing HouseBalkan Medical Journal2146-31232146-31312012-06-01292218221Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five CasesCumali GökçeEsin AtikMehmet Uğur İnanAsena Çiğdem DoğramacıScleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy.http://balkanmedicaljournal.org/text.php3?id=868Scleredemalow-dose methotrexatediabetes mellitus |
| spellingShingle | Cumali Gökçe Esin Atik Mehmet Uğur İnan Asena Çiğdem Doğramacı Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases Balkan Medical Journal Scleredema low-dose methotrexate diabetes mellitus |
| title | Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases |
| title_full | Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases |
| title_fullStr | Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases |
| title_full_unstemmed | Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases |
| title_short | Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases |
| title_sort | scleredema diabeticorum partially treated with low dose methotrexate a report of five cases |
| topic | Scleredema low-dose methotrexate diabetes mellitus |
| url | http://balkanmedicaljournal.org/text.php3?id=868 |
| work_keys_str_mv | AT cumaligokce scleredemadiabeticorumpartiallytreatedwithlowdosemethotrexateareportoffivecases AT esinatik scleredemadiabeticorumpartiallytreatedwithlowdosemethotrexateareportoffivecases AT mehmetugurinan scleredemadiabeticorumpartiallytreatedwithlowdosemethotrexateareportoffivecases AT asenacigdemdogramacı scleredemadiabeticorumpartiallytreatedwithlowdosemethotrexateareportoffivecases |