Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population.
This study investigates age-specific prostate-specific antigen (PSA) distributions in Taiwanese men and recommends reference ranges for this population after comparison with other studies. From January 1999 to December 2016, a total of 213,986 Taiwanese men aged above 19 years old without history of...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0283040 |
| _version_ | 1797862126694432768 |
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| author | Tsung-Hsun Tsai Ta-Wei Chu Tien-Huang Lin Teng-Fu Hsieh Chi-Cheng Chen Hsin-Ho Liu Yuan-Chieh Chuang Chia-Wen Lin Shang-Sen Lee |
| author_facet | Tsung-Hsun Tsai Ta-Wei Chu Tien-Huang Lin Teng-Fu Hsieh Chi-Cheng Chen Hsin-Ho Liu Yuan-Chieh Chuang Chia-Wen Lin Shang-Sen Lee |
| author_sort | Tsung-Hsun Tsai |
| collection | DOAJ |
| description | This study investigates age-specific prostate-specific antigen (PSA) distributions in Taiwanese men and recommends reference ranges for this population after comparison with other studies. From January 1999 to December 2016, a total of 213,986 Taiwanese men aged above 19 years old without history of prostate cancer, urinary tract infection, or prostate infection were recruited from the Taiwan MJ cohort, an ongoing prospective cohort of health examinations conducted by the MJ Health Screening Center in Taiwan. Participants were divided into seven age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each group as reference ranges for serum PSA in screening for prostate cancer in Taiwanese men. Serum PSA concentration correlated with age (r = 0.274, p<0.001). The median serum PSA concentration (5th to 95th percentile) ranged from 0.7 ng/ml (0.3 to 1.8) for men 20-29 years old (n = 6,382) to 1.6 ng/ml (0.4 to 8.4) for men over 79 years old (n = 504). The age-specific PSA reference ranges are as follows: 20-29 years, 1.80 ng/ml; 30-39 years, 1.80 ng/ml; 40-49 years, 2.0 ng/ml; 50-59 years, 3.20 ng/ml; 60-69 years, 5.60 ng/ml; 70-79 years, 7.40 ng/ml; over 80 years, 8.40 ng/ml. Almost no change occurred in the median serum PSA value in men 50 years old or younger, while a gradual increase was observed in men over 50. Taiwanese men aged 60 years above showed higher 95th percentile serum PSA values compared to Caucasian men and men in other Asian countries but were closer to those of Asian American and African American men. Results indicate significantly different PSA levels correlating to different ethnicities, suggesting that Oesterling's age-specific PSA reference ranges might not be appropriate for Taiwanese men. Our results should be further studied to validate the age-specific PSA reference ranges for Taiwanese men presented in this study. |
| first_indexed | 2024-04-09T22:14:14Z |
| format | Article |
| id | doaj.art-a04abdb755894bf595f7ee04d1361034 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T22:14:14Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a04abdb755894bf595f7ee04d13610342023-03-23T05:32:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183e028304010.1371/journal.pone.0283040Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population.Tsung-Hsun TsaiTa-Wei ChuTien-Huang LinTeng-Fu HsiehChi-Cheng ChenHsin-Ho LiuYuan-Chieh ChuangChia-Wen LinShang-Sen LeeThis study investigates age-specific prostate-specific antigen (PSA) distributions in Taiwanese men and recommends reference ranges for this population after comparison with other studies. From January 1999 to December 2016, a total of 213,986 Taiwanese men aged above 19 years old without history of prostate cancer, urinary tract infection, or prostate infection were recruited from the Taiwan MJ cohort, an ongoing prospective cohort of health examinations conducted by the MJ Health Screening Center in Taiwan. Participants were divided into seven age groups. Simple descriptive statistical analyses were carried out and quartiles and 95th percentiles were calculated for each group as reference ranges for serum PSA in screening for prostate cancer in Taiwanese men. Serum PSA concentration correlated with age (r = 0.274, p<0.001). The median serum PSA concentration (5th to 95th percentile) ranged from 0.7 ng/ml (0.3 to 1.8) for men 20-29 years old (n = 6,382) to 1.6 ng/ml (0.4 to 8.4) for men over 79 years old (n = 504). The age-specific PSA reference ranges are as follows: 20-29 years, 1.80 ng/ml; 30-39 years, 1.80 ng/ml; 40-49 years, 2.0 ng/ml; 50-59 years, 3.20 ng/ml; 60-69 years, 5.60 ng/ml; 70-79 years, 7.40 ng/ml; over 80 years, 8.40 ng/ml. Almost no change occurred in the median serum PSA value in men 50 years old or younger, while a gradual increase was observed in men over 50. Taiwanese men aged 60 years above showed higher 95th percentile serum PSA values compared to Caucasian men and men in other Asian countries but were closer to those of Asian American and African American men. Results indicate significantly different PSA levels correlating to different ethnicities, suggesting that Oesterling's age-specific PSA reference ranges might not be appropriate for Taiwanese men. Our results should be further studied to validate the age-specific PSA reference ranges for Taiwanese men presented in this study.https://doi.org/10.1371/journal.pone.0283040 |
| spellingShingle | Tsung-Hsun Tsai Ta-Wei Chu Tien-Huang Lin Teng-Fu Hsieh Chi-Cheng Chen Hsin-Ho Liu Yuan-Chieh Chuang Chia-Wen Lin Shang-Sen Lee Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. PLoS ONE |
| title | Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. |
| title_full | Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. |
| title_fullStr | Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. |
| title_full_unstemmed | Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. |
| title_short | Ethnic differences in the age-related distribution of serum prostate-specific antigen values: A study in a Taiwanese male population. |
| title_sort | ethnic differences in the age related distribution of serum prostate specific antigen values a study in a taiwanese male population |
| url | https://doi.org/10.1371/journal.pone.0283040 |
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