Dysfunctional mitochondria, disrupted levels of reactive oxygen species, and autophagy in B cells from common variable immunodeficiency patients

Dysfunctional mitochondria, disrupted levels of reactive oxygen species, and autophagy in B cells from common variable immunodeficiency patients

IntroductionCommon Variable Immunodeficiency (CVID) patients are characterized by hypogammaglobulinemia and poor response to vaccination due to deficient generation of memory and antibody-secreting B cells. B lymphocytes are essential for the development of humoral immune responses, and mitochondria...

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Bibliographic Details
Main Authors: Maria Berman-Riu, Vanesa Cunill, Antonio Clemente, Antonio López-Gómez, Jaime Pons, Joana M. Ferrer
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
B cells
CVID
autophagy
ROS
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1362995/full

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