Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome
Summary Infection by Mycoplasma pneumoniae has been identified as a preceding factor of Guillain–Barré–Stohl syndrome. The Guillain–Barré–Stohl syndrome is triggered by an immune reaction against the major glycolipids and it has been postulated that M. pneumoniae infection triggers this syndrome due...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Microbial Biotechnology |
| Online Access: | https://doi.org/10.1111/1751-7915.13794 |
| _version_ | 1818430111167283200 |
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| author | Erika Gaspari Jasper J. Koehorst Joachim Frey Vitor A.P. Martins dos Santos Maria Suarez‐Diez |
| author_facet | Erika Gaspari Jasper J. Koehorst Joachim Frey Vitor A.P. Martins dos Santos Maria Suarez‐Diez |
| author_sort | Erika Gaspari |
| collection | DOAJ |
| description | Summary Infection by Mycoplasma pneumoniae has been identified as a preceding factor of Guillain–Barré–Stohl syndrome. The Guillain–Barré–Stohl syndrome is triggered by an immune reaction against the major glycolipids and it has been postulated that M. pneumoniae infection triggers this syndrome due to bacterial production of galactocerebroside. Here, we present an extensive comparison of 224 genome sequences from 104 Mycoplasma species to characterize the genetic determinants of galactocerebroside biosynthesis. Hidden Markov models were used to analyse glycosil transferases, leading to identification of a functional protein domain, termed M2000535 that appears in about a third of the studied genomes. This domain appears to be associated with a potential UDP‐glucose epimerase, which converts UDP‐glucose into UDP‐galactose, a main substrate for the biosynthesis of galactocerebroside. These findings clarify the pathogenic mechanisms underlining the triggering of Guillain–Barré–Stohl syndrome by M. pneumoniae infections. |
| first_indexed | 2024-12-14T15:28:13Z |
| format | Article |
| id | doaj.art-a04b577cf7f149299d4481d8821463cd |
| institution | Directory Open Access Journal |
| issn | 1751-7915 |
| language | English |
| last_indexed | 2024-12-14T15:28:13Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj.art-a04b577cf7f149299d4481d8821463cd2022-12-21T22:55:59ZengWileyMicrobial Biotechnology1751-79152021-05-011431201121110.1111/1751-7915.13794Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndromeErika Gaspari0Jasper J. Koehorst1Joachim Frey2Vitor A.P. Martins dos Santos3Maria Suarez‐Diez4Laboratory of Systems and Synthetic Biology Wageningen University & Research Wageningen the NetherlandsLaboratory of Systems and Synthetic Biology Wageningen University & Research Wageningen the NetherlandsVetsuisse University of Bern Bern SwitzerlandLaboratory of Systems and Synthetic Biology Wageningen University & Research Wageningen the NetherlandsLaboratory of Systems and Synthetic Biology Wageningen University & Research Wageningen the NetherlandsSummary Infection by Mycoplasma pneumoniae has been identified as a preceding factor of Guillain–Barré–Stohl syndrome. The Guillain–Barré–Stohl syndrome is triggered by an immune reaction against the major glycolipids and it has been postulated that M. pneumoniae infection triggers this syndrome due to bacterial production of galactocerebroside. Here, we present an extensive comparison of 224 genome sequences from 104 Mycoplasma species to characterize the genetic determinants of galactocerebroside biosynthesis. Hidden Markov models were used to analyse glycosil transferases, leading to identification of a functional protein domain, termed M2000535 that appears in about a third of the studied genomes. This domain appears to be associated with a potential UDP‐glucose epimerase, which converts UDP‐glucose into UDP‐galactose, a main substrate for the biosynthesis of galactocerebroside. These findings clarify the pathogenic mechanisms underlining the triggering of Guillain–Barré–Stohl syndrome by M. pneumoniae infections.https://doi.org/10.1111/1751-7915.13794 |
| spellingShingle | Erika Gaspari Jasper J. Koehorst Joachim Frey Vitor A.P. Martins dos Santos Maria Suarez‐Diez Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome Microbial Biotechnology |
| title | Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome |
| title_full | Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome |
| title_fullStr | Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome |
| title_full_unstemmed | Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome |
| title_short | Galactocerebroside biosynthesis pathways of Mycoplasma species: an antigen triggering Guillain–Barré–Stohl syndrome |
| title_sort | galactocerebroside biosynthesis pathways of mycoplasma species an antigen triggering guillain barre stohl syndrome |
| url | https://doi.org/10.1111/1751-7915.13794 |
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