Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B

Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B

Conventional treatment of chronic hepatitis B (CHB) is rarely curative due to the immunotolerant status of patients. RG7854 is an oral double prodrug of a toll-like receptor 7 (TLR7) agonist that is developed for the treatment of CHB. The therapeutic efficacy, host immune response, and safety of RG7...

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Bibliographic Details
Main Authors: Steffen Wildum, Kyle E. Korolowicz, Manasa Suresh, Guido Steiner, Lue Dai, Bin Li, Changsuek Yon, Maria Cristina De Vera Mudry, Franziska Regenass-Lechner, Xu Huang, Xupeng Hong, Marta G. Murreddu, Bhaskar V. Kallakury, John A. T. Young, Stephan Menne
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
chronic hepatitis B
woodchuck
TLR7 agonism
RG7854
functional cure
entecavir
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884113/full

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