Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Abstract Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Cellular & Molecular Biology Letters |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s11658-024-00560-2 |
| _version_ | 1797233475733946368 |
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| author | Shasha Xiang Wen Yan Xing Ren Jianbo Feng Xuyu Zu |
| author_facet | Shasha Xiang Wen Yan Xing Ren Jianbo Feng Xuyu Zu |
| author_sort | Shasha Xiang |
| collection | DOAJ |
| description | Abstract Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC −/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis. |
| first_indexed | 2024-04-24T16:16:46Z |
| format | Article |
| id | doaj.art-a04b9fb2c268492c95b844259207f47a |
| institution | Directory Open Access Journal |
| issn | 1689-1392 |
| language | English |
| last_indexed | 2024-04-24T16:16:46Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj.art-a04b9fb2c268492c95b844259207f47a2024-03-31T11:26:34ZengBMCCellular & Molecular Biology Letters1689-13922024-03-0129112110.1186/s11658-024-00560-2Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancerShasha Xiang0Wen Yan1Xing Ren2Jianbo Feng3Xuyu Zu4Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaCancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaDepartment of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaCancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaCancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South ChinaAbstract Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the XC −/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.https://doi.org/10.1186/s11658-024-00560-2LncRNABreast cancerFerroptosisFerroptosis-related lncRNABiomarker |
| spellingShingle | Shasha Xiang Wen Yan Xing Ren Jianbo Feng Xuyu Zu Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer Cellular & Molecular Biology Letters LncRNA Breast cancer Ferroptosis Ferroptosis-related lncRNA Biomarker |
| title | Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer |
| title_full | Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer |
| title_fullStr | Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer |
| title_full_unstemmed | Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer |
| title_short | Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer |
| title_sort | role of ferroptosis and ferroptosis related long non coding rna in breast cancer |
| topic | LncRNA Breast cancer Ferroptosis Ferroptosis-related lncRNA Biomarker |
| url | https://doi.org/10.1186/s11658-024-00560-2 |
| work_keys_str_mv | AT shashaxiang roleofferroptosisandferroptosisrelatedlongnoncodingrnainbreastcancer AT wenyan roleofferroptosisandferroptosisrelatedlongnoncodingrnainbreastcancer AT xingren roleofferroptosisandferroptosisrelatedlongnoncodingrnainbreastcancer AT jianbofeng roleofferroptosisandferroptosisrelatedlongnoncodingrnainbreastcancer AT xuyuzu roleofferroptosisandferroptosisrelatedlongnoncodingrnainbreastcancer |