Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9
The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and f...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.906916/full |
| _version_ | 1811322177982562304 |
|---|---|
| author | Je-Oh Lim Yun Hee Kim Ik Soo Lee Woong-Il Kim Se-Jin Lee So-Won Pak In-Sik Shin Taesoo Kim |
| author_facet | Je-Oh Lim Yun Hee Kim Ik Soo Lee Woong-Il Kim Se-Jin Lee So-Won Pak In-Sik Shin Taesoo Kim |
| author_sort | Je-Oh Lim |
| collection | DOAJ |
| description | The prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and fever in Donguibogam, a medical encyclopedia of Korea. Therefore, we investigated whether C. cassia (L.) J.Presl extract (CCE) confers protective effects on asthma model induced by ovalbumin (OVA). The animals were received intraperitoneal administration of OVA on day 1 and 14, and then subjected to OVA inhalation from day 21–23. They were orally treated CCE (30 and 100 mg/kg) from day 18–23. CCE administration decreased allergic responses, including airway hyperresponsiveness, eosinophilia, inflammatory cytokine production, and immunoglobulin E in OVA-exposed mice, along with the decline in inflammatory cell count and mucus secretion in respiratory tract. Additionally, CCE suppressed MAPK phosphorylation and MMP-9 expression in OVA-exposed mice. Overall, CCE treatment attenuated allergic responses induced by OVA exposure, which may be connected to the suppression of MAPK phosphorylation. |
| first_indexed | 2024-04-13T13:30:42Z |
| format | Article |
| id | doaj.art-a04cf4dd44e74da7af5a7eba12aa0bb3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T13:30:42Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-a04cf4dd44e74da7af5a7eba12aa0bb32022-12-22T02:45:00ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.906916906916Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9Je-Oh Lim0Yun Hee Kim1Ik Soo Lee2Woong-Il Kim3Se-Jin Lee4So-Won Pak5In-Sik Shin6Taesoo Kim7College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, South KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, South KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, South KoreaCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, South KoreaCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, South KoreaCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, South KoreaCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, South KoreaR&D Strategy Division, Korea Institute of Oriental Medicine, Daejeon, South KoreaThe prevalence of asthma is gradually increasing, and endangers human health. Many therapeutic agents have been developed to address this concern. Cinnamomum cassia (L.) J.Presl is a traditional herbal remedy in China, Japan, and Korea and used mainly to control common cold, cough, pneumonitis and fever in Donguibogam, a medical encyclopedia of Korea. Therefore, we investigated whether C. cassia (L.) J.Presl extract (CCE) confers protective effects on asthma model induced by ovalbumin (OVA). The animals were received intraperitoneal administration of OVA on day 1 and 14, and then subjected to OVA inhalation from day 21–23. They were orally treated CCE (30 and 100 mg/kg) from day 18–23. CCE administration decreased allergic responses, including airway hyperresponsiveness, eosinophilia, inflammatory cytokine production, and immunoglobulin E in OVA-exposed mice, along with the decline in inflammatory cell count and mucus secretion in respiratory tract. Additionally, CCE suppressed MAPK phosphorylation and MMP-9 expression in OVA-exposed mice. Overall, CCE treatment attenuated allergic responses induced by OVA exposure, which may be connected to the suppression of MAPK phosphorylation.https://www.frontiersin.org/articles/10.3389/fphar.2022.906916/fullCinnamomum cassia (L.) J.PreslasthmaMAPKsMMP-9mice (balb/c) |
| spellingShingle | Je-Oh Lim Yun Hee Kim Ik Soo Lee Woong-Il Kim Se-Jin Lee So-Won Pak In-Sik Shin Taesoo Kim Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 Frontiers in Pharmacology Cinnamomum cassia (L.) J.Presl asthma MAPKs MMP-9 mice (balb/c) |
| title | Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 |
| title_full | Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 |
| title_fullStr | Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 |
| title_full_unstemmed | Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 |
| title_short | Cinnamomum cassia (L.) J.Presl Alleviates Allergic Responses in Asthmatic Mice via Suppression of MAPKs and MMP-9 |
| title_sort | cinnamomum cassia l j presl alleviates allergic responses in asthmatic mice via suppression of mapks and mmp 9 |
| topic | Cinnamomum cassia (L.) J.Presl asthma MAPKs MMP-9 mice (balb/c) |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.906916/full |
| work_keys_str_mv | AT jeohlim cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT yunheekim cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT iksoolee cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT woongilkim cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT sejinlee cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT sowonpak cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT insikshin cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 AT taesookim cinnamomumcassialjpreslalleviatesallergicresponsesinasthmaticmiceviasuppressionofmapksandmmp9 |