The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation

The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation

Abstract In patients with chronic aortic regurgitation (AR), excessive preload and afterload increase left ventricle wall stress, leading to left ventricular systolic dysfunction. Thus, the objective of the present study was to evaluate the effects of the myosin activator omecamtiv mecarbil (OM) on...

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Bibliographic Details
Main Authors: Bachar El Oumeiri, Philippe van deBorne, Géraldine Hubesch, Antoine Herpain, Filippo Annoni, Pascale Jespers, Constantin Stefanidis, Kathleen Mc Entee, Frédéric Vanden Eynden
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:Physiological Reports
Subjects:
aortic regurgitation
omecamtiv mecarbil
overload
wall stress
Online Access:https://doi.org/10.14814/phy2.14988

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