The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain
A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods:...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2010-05-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-28&slc_lang=en&sid=1 |
| _version_ | 1797280458824744960 |
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| author | Mehdi Mehdizadeh Majid Katebi Mansoure Soleimani Mohammad Hassan Farahani Pad Ali Hoseini Tehrani Mohammad Taghi Joghataei |
| author_facet | Mehdi Mehdizadeh Majid Katebi Mansoure Soleimani Mohammad Hassan Farahani Pad Ali Hoseini Tehrani Mohammad Taghi Joghataei |
| author_sort | Mehdi Mehdizadeh |
| collection | DOAJ |
| description | A B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat. |
| first_indexed | 2024-03-07T16:40:35Z |
| format | Article |
| id | doaj.art-a04f2706cf2d4861a5e21c6a027d4291 |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T16:40:35Z |
| publishDate | 2010-05-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-a04f2706cf2d4861a5e21c6a027d42912024-03-03T08:32:14ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422010-05-01131720The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat BrainMehdi MehdizadehMajid KatebiMansoure SoleimaniMohammad Hassan Farahani PadAli Hoseini TehraniMohammad Taghi JoghataeiA B S T R A C T Introduction: Even today there is no effective drug therapy to prevent neuronal loss after brain stroke. In the present study we studied the effect of mitochondrial KATP channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. Materials & Methods: Rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with or without K-ATP channel regulators. Results: Neuronal ultrastructure significantly improved in K-ATP channel opener (diazoxide) treated ischemia-reperfusion group compared with control group. Discussion: Our results showed that dizoxide treatment after ischemia reperfusion leads to better preservation of cortical neurons in rat.http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-28&slc_lang=en&sid=1Ischemia-ReperfusionDiazoxideUltrastructural Changes |
| spellingShingle | Mehdi Mehdizadeh Majid Katebi Mansoure Soleimani Mohammad Hassan Farahani Pad Ali Hoseini Tehrani Mohammad Taghi Joghataei The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain Basic and Clinical Neuroscience Ischemia-Reperfusion Diazoxide Ultrastructural Changes |
| title | The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain |
| title_full | The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain |
| title_fullStr | The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain |
| title_full_unstemmed | The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain |
| title_short | The Effect of Diazoxide on Ultrastructural Changes Following Ischemia-Reperfusion Injury of Rat Brain |
| title_sort | effect of diazoxide on ultrastructural changes following ischemia reperfusion injury of rat brain |
| topic | Ischemia-Reperfusion Diazoxide Ultrastructural Changes |
| url | http://bcn.tums.ac.ir/browse.php?a_code=A-10-1-28&slc_lang=en&sid=1 |
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