Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease
AimsLimited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifi...
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1212882/full |
| _version_ | 1827366482970935296 |
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| author | Ayako Chida-Nagai Ayako Chida-Nagai Ayako Chida-Nagai Naoki Masaki Kay Maeda Konosuke Sasaki Hiroki Sato Hiroki Sato Jun Muneuchi Yoshie Ochiai Hiroomi Murayama Masahiro Tahara Atsuko Shiono Atsushi Shinozuka Fumihiko Kono Daisuke Machida Shinichi Toyooka Seiichiro Sugimoto Kazufumi Nakamura Satoshi Akagi Maiko Kondo Shingo Kasahara Yasuhiro Kotani Junichi Koizumi Katsuhiko Oda Masako Harada Daisuke Nakajima Akira Murata Hazumu Nagata Koichi Yatsunami Tomio Kobayashi Yoshikiyo Matsunaga Takahiro Inoue Hiroyuki Yamagishi Naomi Nakagawa Katsuki Ohtani Masaki Yamamoto Yushi Ito Tatsunori Hokosaki Yuta Kuwahara Satoshi Masutani Satoshi Masutani Koji Nomura Tsutomu Wada Hirofumi Sawada Masayuki Abiko Tatsunori Takahashi Yuichi Ishikawa Seigo Okada Atsushi Naitoh Takako Toda Tatsuya Ando Akihiro Masuzawa Shinsuke Hoshino Masaaki Kawada Yuichi Nomura Kentaro Ueno Naoki Ohashi Tsuyoshi Tachibana Yuchen Cao Hideaki Ueda Sadamitsu Yanagi Masaaki Koide Norie Mitsushita Kouji Higashi Yoshihiro Minosaki Tomohiro Hayashi Takashi Okamoto Kenji Kuraishi Eiji Ehara Hidekazu Ishida Hitoshi Horigome Takashi Murakami Kohta Takei Taku Ishii Taku Ishii Gen Harada Yasutaka Hirata Jun Maeda Shunsuke Tatebe Chiharu Ota Yasunobu Hayabuchi Hisanori Sakazaki Takashi Sasaki Keiichi Hirono Sayo Suzuki Masahiro Yasuda Atsuhito Takeda Madoka Sawada Kagami Miyaji Atsushi Kitagawa Yosuke Nakai Nobuyuki Kakimoto Kouta Agematsu Atsushi Manabe Yoshikatsu Saiki |
| author_facet | Ayako Chida-Nagai Ayako Chida-Nagai Ayako Chida-Nagai Naoki Masaki Kay Maeda Konosuke Sasaki Hiroki Sato Hiroki Sato Jun Muneuchi Yoshie Ochiai Hiroomi Murayama Masahiro Tahara Atsuko Shiono Atsushi Shinozuka Fumihiko Kono Daisuke Machida Shinichi Toyooka Seiichiro Sugimoto Kazufumi Nakamura Satoshi Akagi Maiko Kondo Shingo Kasahara Yasuhiro Kotani Junichi Koizumi Katsuhiko Oda Masako Harada Daisuke Nakajima Akira Murata Hazumu Nagata Koichi Yatsunami Tomio Kobayashi Yoshikiyo Matsunaga Takahiro Inoue Hiroyuki Yamagishi Naomi Nakagawa Katsuki Ohtani Masaki Yamamoto Yushi Ito Tatsunori Hokosaki Yuta Kuwahara Satoshi Masutani Satoshi Masutani Koji Nomura Tsutomu Wada Hirofumi Sawada Masayuki Abiko Tatsunori Takahashi Yuichi Ishikawa Seigo Okada Atsushi Naitoh Takako Toda Tatsuya Ando Akihiro Masuzawa Shinsuke Hoshino Masaaki Kawada Yuichi Nomura Kentaro Ueno Naoki Ohashi Tsuyoshi Tachibana Yuchen Cao Hideaki Ueda Sadamitsu Yanagi Masaaki Koide Norie Mitsushita Kouji Higashi Yoshihiro Minosaki Tomohiro Hayashi Takashi Okamoto Kenji Kuraishi Eiji Ehara Hidekazu Ishida Hitoshi Horigome Takashi Murakami Kohta Takei Taku Ishii Taku Ishii Gen Harada Yasutaka Hirata Jun Maeda Shunsuke Tatebe Chiharu Ota Yasunobu Hayabuchi Hisanori Sakazaki Takashi Sasaki Keiichi Hirono Sayo Suzuki Masahiro Yasuda Atsuhito Takeda Madoka Sawada Kagami Miyaji Atsushi Kitagawa Yosuke Nakai Nobuyuki Kakimoto Kouta Agematsu Atsushi Manabe Yoshikatsu Saiki |
| author_sort | Ayako Chida-Nagai |
| collection | DOAJ |
| description | AimsLimited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH.MethodsThis retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death.ResultsThe 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45–13.73; P = .009).ConclusionsThe IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered. |
| first_indexed | 2024-03-08T08:50:35Z |
| format | Article |
| id | doaj.art-a0503c2d2e004c1599714824bff4c9ec |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T08:50:35Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-a0503c2d2e004c1599714824bff4c9ec2024-02-01T10:53:54ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.12128821212882Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart diseaseAyako Chida-Nagai0Ayako Chida-Nagai1Ayako Chida-Nagai2Naoki Masaki3Kay Maeda4Konosuke Sasaki5Hiroki Sato6Hiroki Sato7Jun Muneuchi8Yoshie Ochiai9Hiroomi Murayama10Masahiro Tahara11Atsuko Shiono12Atsushi Shinozuka13Fumihiko Kono14Daisuke Machida15Shinichi Toyooka16Seiichiro Sugimoto17Kazufumi Nakamura18Satoshi Akagi19Maiko Kondo20Shingo Kasahara21Yasuhiro Kotani22Junichi Koizumi23Katsuhiko Oda24Masako Harada25Daisuke Nakajima26Akira Murata27Hazumu Nagata28Koichi Yatsunami29Tomio Kobayashi30Yoshikiyo Matsunaga31Takahiro Inoue32Hiroyuki Yamagishi33Naomi Nakagawa34Katsuki Ohtani35Masaki Yamamoto36Yushi Ito37Tatsunori Hokosaki38Yuta Kuwahara39Satoshi Masutani40Satoshi Masutani41Koji Nomura42Tsutomu Wada43Hirofumi Sawada44Masayuki Abiko45Tatsunori Takahashi46Yuichi Ishikawa47Seigo Okada48Atsushi Naitoh49Takako Toda50Tatsuya Ando51Akihiro Masuzawa52Shinsuke Hoshino53Masaaki Kawada54Yuichi Nomura55Kentaro Ueno56Naoki Ohashi57Tsuyoshi Tachibana58Yuchen Cao59Hideaki Ueda60Sadamitsu Yanagi61Masaaki Koide62Norie Mitsushita63Kouji Higashi64Yoshihiro Minosaki65Tomohiro Hayashi66Takashi Okamoto67Kenji Kuraishi68Eiji Ehara69Hidekazu Ishida70Hitoshi Horigome71Takashi Murakami72Kohta Takei73Taku Ishii74Taku Ishii75Gen Harada76Yasutaka Hirata77Jun Maeda78Shunsuke Tatebe79Chiharu Ota80Yasunobu Hayabuchi81Hisanori Sakazaki82Takashi Sasaki83Keiichi Hirono84Sayo Suzuki85Masahiro Yasuda86Atsuhito Takeda87Madoka Sawada88Kagami Miyaji89Atsushi Kitagawa90Yosuke Nakai91Nobuyuki Kakimoto92Kouta Agematsu93Atsushi Manabe94Yoshikatsu Saiki95Department of Pediatrics, Hokkaido University, Sapporo, JapanDivision of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University, Tokyo, JapanDivision of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanDivision of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanDivision of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanDepartment of Cardiology and Clinical Examination, Oita University, Yufu, JapanAdvanced Trauma, Emergency and Critical Care Center, Oita University Hospital, Yufu, JapanDepartment of Pediatrics, Kyushu Hospital, Japan Community Healthcare Organization, Kitakyushu, JapanDepartment of Cardiovascular Surgery, Kyushu Hospital, Japan Community Healthcare Organization, Kitakyushu, JapanDepartment of Cardiovascular Surgery, Aichi Children’s Health and Medical Center, Obu, JapanDepartment of Pediatrics, Tsuchiya General Hospital, Hiroshima, Japan0Department of Pediatric Cardiology, Ibaraki Children’s Hospital, Mito, Japan1Department of Pediatrics, Uji-Tokushukai Medical Center, Kyoto, Japan2Department of Diagnostic Pathology, Uji-Tokushukai Medical Center, Kyoto, Japan3Cardiovascular Center, Yokohama City University Medical Center, Yokohama, Japan4Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan4Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan5Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan5Department of Cardiovascular Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan6Department of Pediatrics, Okayama University Hospital, Okayama, Japan7Department of Cardiovascular Surgery, Okayama University, Okayama, Japan7Department of Cardiovascular Surgery, Okayama University, Okayama, Japan8Department of Cardiovascular Surgery, Iwate Medical University Hospital, Yahaba, Japan9Department of Cardiovascular Surgery, Iwate Prefectural Central Hospital, Morioka, Japan0Division of Pediatrics, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan1Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan2Department of Cardiovascular Surgery, Kanazawa University, Kanazawa, Japan3Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan4Department of Pediatric Cardiology, Kumamoto City Hospital, Kumamoto, Japan5Division of Cardiology, Gunma Children’s Medical Center, Shibukawa, Japan6Department of Cardiovascular Surgery,Gunma Children’s Medical Center, Shibukawa, Japan7Department of Pediatrics, Gunma University Graduate School of Medicine, Maebashi, Japan8Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan9Department of Pediatric Cardiology, Hiroshima City Hospital, Hiroshima, Japan0Department of Pediatric Cardiology, Hirosaki University School of Medicine, Hirosaki, Japan1Department of Pediatrics, Kochi Medical School, Kochi University, Nankoku, Japan2Division of Neonatology, Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan3Department of Pediatric Cardiology, Yokohama City University Hospital, Yokohama, Japan4Department of Pediatric Cardiovascular Surgery, Sakakibara Heart Institute, Tokyo, Japan5Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan6Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Hidaka, Japan7Department of Pediatric Cardiovascular Surgery, Saitama Children’s Medical Center, Saitama, Japan8Department of Pediatrics, School of Medicine Sapporo Medical University, Sapporo, Japan9Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan0Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata, Japan0Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata, Japan1Department of Pediatrics, Saiseikai Shimonoseki General Hospital, Shimonoseki, Japan2Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan3Department of Neonatology, Yamanashi Prefectural Central Hospital, Kofu, Japan4Department of Pediatrics, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan5Department of Paediatrics, The Jikei University School of Medicine, Tokyo, Japan6Department of Cardiac Surgery, The Jikei University School of Medicine, Tokyo, Japan7Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan8Department of Cardiac Surgery, Section of Pediatric and Congenital Cardiovascular Surgery, Jichi Medical University, Shimotsuke, Japan9Department of Pediatrics, Kagoshima City Hospital, Kagoshima, Japan0Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan1Department of Pediatric Cardiology, Chukyo Children Heart Centre, Community Health Care Organization Chukyo Hospital, Nagoya, Japan2Department of Cardiovascular Surgery, Kanagawa Children’s Medical Center, Yokohama, Japan2Department of Cardiovascular Surgery, Kanagawa Children’s Medical Center, Yokohama, Japan3Department of Pediatric Cardiology, Kanagawa Children’s Medical Center, Yokohama, Japan3Department of Pediatric Cardiology, Kanagawa Children’s Medical Center, Yokohama, Japan4Department of Cardiovascular Surgery, Seirei Hamamatsu General Hospital, Shizuoka, Japan5Department of Cardiology, Shizuoka Children’s Hospital, Shizuoka, Japan6Division of Cardiology, Chiba Children's Hospital, Chiba, Japan7Neonatal Intensive Care Unit, Kawaguchi Municipal Medical Center, Kawaguchi, Japan8Department of Pediatrics, Kurashiki Central Hospital, Okayama, Japan9Department of Cardiac Surgery, Daiyukai General Hospital, Ichinomiya, Japan0Department of Pediatric Cardiology and Neonatology, Ogaki Municipal Hospital, Gifu, Japan1Department of Pediatric Cardiology, Osaka City General Hospital, Osaka, Japan2Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan3Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan3Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan4Department of Pediatric Cardiology, Nagano Children’s Hospital, Azumino, Japan5Department of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan6Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Pediatric Cardiology and Adult Congenital Cardiology, Tokyo Women’s Medical University, Tokyo, Japan7Department of Cardiac Surgery, The University of Tokyo Hospital, Tokyo, Japan8Department of Cardiology, Tokyo Metropolitan Children’s Medical Center, Fuchu, Japan9Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan0Department of Pediatrics, Tohoku University Hospital, Sendai, Japan1Department of Pediatrics, School of Medicine, University of Tokushima, Tokushima, Japan2Department of Pediatric Cardiology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan3Department of Cardiovascular Surgery, Nippon Medical School, Tokyo, Japan4Department of Pediatrics, Faculty of Medicine, University of Toyama, Toyama, Japan5Department of Cardiology, Fukuoka Children’s Hospital, Fukuoka, Japan6Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, JapanDepartment of Pediatrics, Hokkaido University, Sapporo, Japan7Department of Pediatric Cardiology, Hokkaido Medical Center for Child Health and Rehabilitation, Sapporo, Japan8Department of Cardiovascular Surgery, Kitasato University School of Medicine, Sagamihara, Japan9Department of Pediatrics, Kitasato University School of Medicine, Sagamihara, Japan0Department of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan1Department of Pediatrics, Wakayama Medical University, Wakayama, Japan2Departmentof Thoracic and Cardiovascular Surgery, Wakayama Medical University, Wakayama, JapanDepartment of Pediatrics, Hokkaido University, Sapporo, JapanDivision of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, Sendai, JapanAimsLimited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH.MethodsThis retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death.ResultsThe 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 (P = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45–13.73; P = .009).ConclusionsThe IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1212882/fullindex of pulmonary vascular diseasepulmonary arterial hypertensioncongenital heart diseasepediatricsoutcome |
| spellingShingle | Ayako Chida-Nagai Ayako Chida-Nagai Ayako Chida-Nagai Naoki Masaki Kay Maeda Konosuke Sasaki Hiroki Sato Hiroki Sato Jun Muneuchi Yoshie Ochiai Hiroomi Murayama Masahiro Tahara Atsuko Shiono Atsushi Shinozuka Fumihiko Kono Daisuke Machida Shinichi Toyooka Seiichiro Sugimoto Kazufumi Nakamura Satoshi Akagi Maiko Kondo Shingo Kasahara Yasuhiro Kotani Junichi Koizumi Katsuhiko Oda Masako Harada Daisuke Nakajima Akira Murata Hazumu Nagata Koichi Yatsunami Tomio Kobayashi Yoshikiyo Matsunaga Takahiro Inoue Hiroyuki Yamagishi Naomi Nakagawa Katsuki Ohtani Masaki Yamamoto Yushi Ito Tatsunori Hokosaki Yuta Kuwahara Satoshi Masutani Satoshi Masutani Koji Nomura Tsutomu Wada Hirofumi Sawada Masayuki Abiko Tatsunori Takahashi Yuichi Ishikawa Seigo Okada Atsushi Naitoh Takako Toda Tatsuya Ando Akihiro Masuzawa Shinsuke Hoshino Masaaki Kawada Yuichi Nomura Kentaro Ueno Naoki Ohashi Tsuyoshi Tachibana Yuchen Cao Hideaki Ueda Sadamitsu Yanagi Masaaki Koide Norie Mitsushita Kouji Higashi Yoshihiro Minosaki Tomohiro Hayashi Takashi Okamoto Kenji Kuraishi Eiji Ehara Hidekazu Ishida Hitoshi Horigome Takashi Murakami Kohta Takei Taku Ishii Taku Ishii Gen Harada Yasutaka Hirata Jun Maeda Shunsuke Tatebe Chiharu Ota Yasunobu Hayabuchi Hisanori Sakazaki Takashi Sasaki Keiichi Hirono Sayo Suzuki Masahiro Yasuda Atsuhito Takeda Madoka Sawada Kagami Miyaji Atsushi Kitagawa Yosuke Nakai Nobuyuki Kakimoto Kouta Agematsu Atsushi Manabe Yoshikatsu Saiki Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease Frontiers in Cardiovascular Medicine index of pulmonary vascular disease pulmonary arterial hypertension congenital heart disease pediatrics outcome |
| title | Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| title_full | Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| title_fullStr | Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| title_full_unstemmed | Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| title_short | Use of the index of pulmonary vascular disease for predicting long-term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| title_sort | use of the index of pulmonary vascular disease for predicting long term outcome of pulmonary arterial hypertension associated with congenital heart disease |
| topic | index of pulmonary vascular disease pulmonary arterial hypertension congenital heart disease pediatrics outcome |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1212882/full |
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useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT sadamitsuyanagi useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT masaakikoide useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT noriemitsushita useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT koujihigashi useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT yoshihirominosaki useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT tomohirohayashi 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useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT kohtatakei useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT takuishii useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT takuishii useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT genharada useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT yasutakahirata useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT junmaeda 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useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT sayosuzuki useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT masahiroyasuda useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT atsuhitotakeda useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT madokasawada useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT kagamimiyaji useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT atsushikitagawa useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT yosukenakai useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT nobuyukikakimoto useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT koutaagematsu useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT atsushimanabe useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease AT yoshikatsusaiki useoftheindexofpulmonaryvasculardiseaseforpredictinglongtermoutcomeofpulmonaryarterialhypertensionassociatedwithcongenitalheartdisease |