Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol
Background: To assess gait and balance in patients with essential tremor (ET), which is the most common tremor disorder characterized by bilateral action tremor of the hands with possible involvement of further tremor locations and to test the efficacy of atenolol on tremor and gait and balance. Met...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Neurological Sciences and Neurophysiology |
| Subjects: | |
| Online Access: | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2023;volume=40;issue=4;spage=192;epage=199;aulast=Ayşin |
| _version_ | 1797221714500780032 |
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| author | A K Ayşin Kisabay Gülsüm Saruhan Durmaz Ceyla Ataç Tarik Duksal Figen Gökçay Neşe Çelebisoy |
| author_facet | A K Ayşin Kisabay Gülsüm Saruhan Durmaz Ceyla Ataç Tarik Duksal Figen Gökçay Neşe Çelebisoy |
| author_sort | A K Ayşin Kisabay |
| collection | DOAJ |
| description | Background: To assess gait and balance in patients with essential tremor (ET), which is the most common tremor disorder characterized by bilateral action tremor of the hands with possible involvement of further tremor locations and to test the efficacy of atenolol on tremor and gait and balance. Methods: In this prospective study, gait and balance were evaluated by static posturography in addition to International Cooperative Ataxia Rating Scale (ICARS) in 22 ET patients without any additional neurologic signs on examination. Tremor severity was assessed by The Essential Tremor Rating Assessment Scale (TETRAS). The efficacy of atenolol 100 mg/day both on tremor and gait and balance was investigated. Posturographic recordings were performed in gender, age-, and height-matched healthy volunteers who constituted the control group. Results: The mean center of gravity sway velocity of the ET patients recorded on firm and foam surfaces with eyes open and closed was not significantly different from the healthy controls but sway velocity on tandem stance was significantly increased (P = 0.032). Gait speed (P = 0.015) was decreased and step width was increased (P = 0.001). An improvement in TETRAS scores was recorded with atenolol treatment (P = 0.046). An improvement not reaching statistical significance was present in ICARS scores (P = 0.059). However, posturographic parameters did not change significantly (P > 0.05). Conclusion: Increased sway velocity on tandem stance, decreased gait speed and increased step width are consistent with midline cerebellar dysfunction in ET patients with no obvious gait and balance deficits on clinical examination. Atenolol seems to be effective on tremor but does not cause a significant improvement in gait and balance deficits. |
| first_indexed | 2024-04-24T13:09:49Z |
| format | Article |
| id | doaj.art-a0531b31d9a443b9b6db83ba59cfe371 |
| institution | Directory Open Access Journal |
| issn | 2636-865X |
| language | English |
| last_indexed | 2024-04-24T13:09:49Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neurological Sciences and Neurophysiology |
| spelling | doaj.art-a0531b31d9a443b9b6db83ba59cfe3712024-04-05T05:07:25ZengWolters Kluwer Medknow PublicationsNeurological Sciences and Neurophysiology2636-865X2023-01-0140419219910.4103/nsn.nsn_38_23Tremor, gait, and balance disorders in essential tremor and the efficacy of atenololA K Ayşin KisabayGülsüm Saruhan DurmazCeyla AtaçTarik DuksalFigen GökçayNeşe ÇelebisoyBackground: To assess gait and balance in patients with essential tremor (ET), which is the most common tremor disorder characterized by bilateral action tremor of the hands with possible involvement of further tremor locations and to test the efficacy of atenolol on tremor and gait and balance. Methods: In this prospective study, gait and balance were evaluated by static posturography in addition to International Cooperative Ataxia Rating Scale (ICARS) in 22 ET patients without any additional neurologic signs on examination. Tremor severity was assessed by The Essential Tremor Rating Assessment Scale (TETRAS). The efficacy of atenolol 100 mg/day both on tremor and gait and balance was investigated. Posturographic recordings were performed in gender, age-, and height-matched healthy volunteers who constituted the control group. Results: The mean center of gravity sway velocity of the ET patients recorded on firm and foam surfaces with eyes open and closed was not significantly different from the healthy controls but sway velocity on tandem stance was significantly increased (P = 0.032). Gait speed (P = 0.015) was decreased and step width was increased (P = 0.001). An improvement in TETRAS scores was recorded with atenolol treatment (P = 0.046). An improvement not reaching statistical significance was present in ICARS scores (P = 0.059). However, posturographic parameters did not change significantly (P > 0.05). Conclusion: Increased sway velocity on tandem stance, decreased gait speed and increased step width are consistent with midline cerebellar dysfunction in ET patients with no obvious gait and balance deficits on clinical examination. Atenolol seems to be effective on tremor but does not cause a significant improvement in gait and balance deficits.http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2023;volume=40;issue=4;spage=192;epage=199;aulast=Ayşinatenololessential tremorinternational cooperative ataxia rating scalestatic posturographythe essential tremor rating assessment scale |
| spellingShingle | A K Ayşin Kisabay Gülsüm Saruhan Durmaz Ceyla Ataç Tarik Duksal Figen Gökçay Neşe Çelebisoy Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol Neurological Sciences and Neurophysiology atenolol essential tremor international cooperative ataxia rating scale static posturography the essential tremor rating assessment scale |
| title | Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol |
| title_full | Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol |
| title_fullStr | Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol |
| title_full_unstemmed | Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol |
| title_short | Tremor, gait, and balance disorders in essential tremor and the efficacy of atenolol |
| title_sort | tremor gait and balance disorders in essential tremor and the efficacy of atenolol |
| topic | atenolol essential tremor international cooperative ataxia rating scale static posturography the essential tremor rating assessment scale |
| url | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2023;volume=40;issue=4;spage=192;epage=199;aulast=Ayşin |
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