Gene-encoding DNA origami for mammalian cell expression
DNA origami may enable more versatile gene delivery applications through its ability to create custom nanoscale objects. Here the authors show that genes folded in DNA origami with custom scaffolds express efficiently when delivered to mammalian cells and can be assembled into multimeric arrays to d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36601-1 |
| _version_ | 1797864232964849664 |
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| author | Jessica A. Kretzmann Anna Liedl Alba Monferrer Volodymyr Mykhailiuk Samuel Beerkens Hendrik Dietz |
| author_facet | Jessica A. Kretzmann Anna Liedl Alba Monferrer Volodymyr Mykhailiuk Samuel Beerkens Hendrik Dietz |
| author_sort | Jessica A. Kretzmann |
| collection | DOAJ |
| description | DNA origami may enable more versatile gene delivery applications through its ability to create custom nanoscale objects. Here the authors show that genes folded in DNA origami with custom scaffolds express efficiently when delivered to mammalian cells and can be assembled into multimeric arrays to deliver and express defined ratios of multiple genes simultaneously. |
| first_indexed | 2024-04-09T22:49:36Z |
| format | Article |
| id | doaj.art-a054471706244e8599b5292bb403e4af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:36Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a054471706244e8599b5292bb403e4af2023-03-22T11:42:25ZengNature PortfolioNature Communications2041-17232023-02-0114111010.1038/s41467-023-36601-1Gene-encoding DNA origami for mammalian cell expressionJessica A. Kretzmann0Anna Liedl1Alba Monferrer2Volodymyr Mykhailiuk3Samuel Beerkens4Hendrik Dietz5Department of Biosciences, School of Natural Sciences, Technical University of MunichDepartment of Biosciences, School of Natural Sciences, Technical University of MunichDepartment of Biosciences, School of Natural Sciences, Technical University of MunichDepartment of Biosciences, School of Natural Sciences, Technical University of MunichDepartment of Biosciences, School of Natural Sciences, Technical University of MunichDepartment of Biosciences, School of Natural Sciences, Technical University of MunichDNA origami may enable more versatile gene delivery applications through its ability to create custom nanoscale objects. Here the authors show that genes folded in DNA origami with custom scaffolds express efficiently when delivered to mammalian cells and can be assembled into multimeric arrays to deliver and express defined ratios of multiple genes simultaneously.https://doi.org/10.1038/s41467-023-36601-1 |
| spellingShingle | Jessica A. Kretzmann Anna Liedl Alba Monferrer Volodymyr Mykhailiuk Samuel Beerkens Hendrik Dietz Gene-encoding DNA origami for mammalian cell expression Nature Communications |
| title | Gene-encoding DNA origami for mammalian cell expression |
| title_full | Gene-encoding DNA origami for mammalian cell expression |
| title_fullStr | Gene-encoding DNA origami for mammalian cell expression |
| title_full_unstemmed | Gene-encoding DNA origami for mammalian cell expression |
| title_short | Gene-encoding DNA origami for mammalian cell expression |
| title_sort | gene encoding dna origami for mammalian cell expression |
| url | https://doi.org/10.1038/s41467-023-36601-1 |
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