Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging
Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. O...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/10/1161 |
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| author | Elizaveta A. Maksimova Roman A. Barmin Polina G. Rudakovskaya Olga A. Sindeeva Ekaterina S. Prikhozhdenko Alexey M. Yashchenok Boris N. Khlebtsov Alexander A. Solovev Gaoshan Huang Yongfeng Mei Krishna Kanti Dey Dmitry A. Gorin |
| author_facet | Elizaveta A. Maksimova Roman A. Barmin Polina G. Rudakovskaya Olga A. Sindeeva Ekaterina S. Prikhozhdenko Alexey M. Yashchenok Boris N. Khlebtsov Alexander A. Solovev Gaoshan Huang Yongfeng Mei Krishna Kanti Dey Dmitry A. Gorin |
| author_sort | Elizaveta A. Maksimova |
| collection | DOAJ |
| description | Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications. |
| first_indexed | 2024-03-10T06:23:15Z |
| format | Article |
| id | doaj.art-a05797d67f684eb7bbdc5ed14e80ec1c |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T06:23:15Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-a05797d67f684eb7bbdc5ed14e80ec1c2023-11-22T19:10:45ZengMDPI AGMicromachines2072-666X2021-09-011210116110.3390/mi12101161Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal ImagingElizaveta A. Maksimova0Roman A. Barmin1Polina G. Rudakovskaya2Olga A. Sindeeva3Ekaterina S. Prikhozhdenko4Alexey M. Yashchenok5Boris N. Khlebtsov6Alexander A. Solovev7Gaoshan Huang8Yongfeng Mei9Krishna Kanti Dey10Dmitry A. Gorin11Center for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaCenter for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaCenter for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaCenter for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaScience Medical Center, Saratov State University, 83 Astrakhanskaya Str., 410012 Saratov, RussiaCenter for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaInstitute of Biochemistry and Physiology of Plants and Microorganisms, 410049 Saratov, RussiaDepartment of Materials Science, Fudan University, Shanghai 200433, ChinaDepartment of Materials Science, Fudan University, Shanghai 200433, ChinaDepartment of Materials Science, Fudan University, Shanghai 200433, ChinaDiscipline of Physics, Indian Institute of Technology Gandhinagar Gandhinagar, Gujarat 382355, IndiaCenter for Photonics and Quantum Materials, Skolkovo Institute of Science and Technology, 3 Nobelya Str., 121205 Moscow, RussiaMicrobubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.https://www.mdpi.com/2072-666X/12/10/1161microbubblesbovine serum albumingold nanocageszinc phthalocyanineultrasound imagingfluorescence tomography |
| spellingShingle | Elizaveta A. Maksimova Roman A. Barmin Polina G. Rudakovskaya Olga A. Sindeeva Ekaterina S. Prikhozhdenko Alexey M. Yashchenok Boris N. Khlebtsov Alexander A. Solovev Gaoshan Huang Yongfeng Mei Krishna Kanti Dey Dmitry A. Gorin Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging Micromachines microbubbles bovine serum albumin gold nanocages zinc phthalocyanine ultrasound imaging fluorescence tomography |
| title | Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging |
| title_full | Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging |
| title_fullStr | Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging |
| title_full_unstemmed | Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging |
| title_short | Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging |
| title_sort | air filled microbubbles based on albumin functionalized with gold nanocages and zinc phthalocyanine for multimodal imaging |
| topic | microbubbles bovine serum albumin gold nanocages zinc phthalocyanine ultrasound imaging fluorescence tomography |
| url | https://www.mdpi.com/2072-666X/12/10/1161 |
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