Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis
OBJECTIVE To assess the increased diagnostic yield for pulmonary tuberculosis using bronchial washing cultures compared with sputum cultures. METHODS Study conducted with 61 adults in Lima, Peru, from January 2006 to December 2007. The yield of sputum cultures was compared with the yield of acid-f...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2013-08-01
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| Series: | Revista de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89102013000600813&lng=en&tlng=en |
| _version_ | 1818907196627353600 |
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| author | Alonso Soto Vilma Acurio Lely Solari Patrick Van der Stuyft |
| author_facet | Alonso Soto Vilma Acurio Lely Solari Patrick Van der Stuyft |
| author_sort | Alonso Soto |
| collection | DOAJ |
| description | OBJECTIVE To assess the increased diagnostic yield for pulmonary tuberculosis using bronchial washing cultures compared with sputum cultures. METHODS Study conducted with 61 adults in Lima, Peru, from January 2006 to December 2007. The yield of sputum cultures was compared with the yield of acid-fast bacilli smears and cultures of bronchial washing for diagnosing pulmonary tuberculosis in suspected cases of clinical tuberculosis with negative acid fast bacilli sputum smears. RESULTS Twenty seven (95%CI 32;58) of the cases were eventually diagnosed with smear-negative pulmonary tuberculosis. Bronchial washing samples detected 23 (95%CI 72;99) of the smear-negative pulmonary tuberculosis cases compared with 15 (95%CI 37;74) for sputum cultures (p = 0.02). The incremental diagnostic yield of acid fast bacilli smear and culture of bronchial washing specimens over sputum culture was 44% (95%CI 25;65). CONCLUSIONS In function of the epidemiological context and the resources available, bronchoscopy should be deployed as part of a comprehensive work up that optimizes smear-negative pulmonary tuberculosis diagnosis and minimizes risk and costs. |
| first_indexed | 2024-12-19T21:51:17Z |
| format | Article |
| id | doaj.art-a0593eda326b4897838d3cd9ce21b61a |
| institution | Directory Open Access Journal |
| issn | 0034-8910 |
| language | English |
| last_indexed | 2024-12-19T21:51:17Z |
| publishDate | 2013-08-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Revista de Saúde Pública |
| spelling | doaj.art-a0593eda326b4897838d3cd9ce21b61a2022-12-21T20:04:24ZengUniversidade de São PauloRevista de Saúde Pública0034-89102013-08-0147481381610.1590/S0034-8910.2013047004548S0034-89102013000600813Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosisAlonso SotoVilma AcurioLely SolariPatrick Van der StuyftOBJECTIVE To assess the increased diagnostic yield for pulmonary tuberculosis using bronchial washing cultures compared with sputum cultures. METHODS Study conducted with 61 adults in Lima, Peru, from January 2006 to December 2007. The yield of sputum cultures was compared with the yield of acid-fast bacilli smears and cultures of bronchial washing for diagnosing pulmonary tuberculosis in suspected cases of clinical tuberculosis with negative acid fast bacilli sputum smears. RESULTS Twenty seven (95%CI 32;58) of the cases were eventually diagnosed with smear-negative pulmonary tuberculosis. Bronchial washing samples detected 23 (95%CI 72;99) of the smear-negative pulmonary tuberculosis cases compared with 15 (95%CI 37;74) for sputum cultures (p = 0.02). The incremental diagnostic yield of acid fast bacilli smear and culture of bronchial washing specimens over sputum culture was 44% (95%CI 25;65). CONCLUSIONS In function of the epidemiological context and the resources available, bronchoscopy should be deployed as part of a comprehensive work up that optimizes smear-negative pulmonary tuberculosis diagnosis and minimizes risk and costs.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89102013000600813&lng=en&tlng=enLavado BroncoalveolarTuberculosis, diagnosticoTecnicas y Procedimientos DiagnosticosSensibilidad y Especificidad |
| spellingShingle | Alonso Soto Vilma Acurio Lely Solari Patrick Van der Stuyft Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis Revista de Saúde Pública Lavado Broncoalveolar Tuberculosis, diagnostico Tecnicas y Procedimientos Diagnosticos Sensibilidad y Especificidad |
| title | Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis |
| title_full | Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis |
| title_fullStr | Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis |
| title_full_unstemmed | Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis |
| title_short | Incremental yield of bronchial washing for diagnosing smear-negative pulmonary tuberculosis |
| title_sort | incremental yield of bronchial washing for diagnosing smear negative pulmonary tuberculosis |
| topic | Lavado Broncoalveolar Tuberculosis, diagnostico Tecnicas y Procedimientos Diagnosticos Sensibilidad y Especificidad |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0034-89102013000600813&lng=en&tlng=en |
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