Inhibitory Effects of Nobiletin on Voltage-Gated Na<sup>+</sup> Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method

Inhibitory Effects of Nobiletin on Voltage-Gated Na<sup>+</sup> Channel in Rat Ventricular Myocytes Based on Electrophysiological Analysis and Molecular Docking Method

Nobiletin (NOB) has attracted much attention owing to its outstanding bioactivities. This study aimed to investigate its anti-arrhythmic effect through electrophysiological and molecular docking studies. We assessed the anti-arrhythmic effects of NOB using aconitine-induced ventricular arrhythmia in...

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Bibliographic Details
Main Authors: Youwei Gu, Jieru Wang, Mengting Li, Fei Zhong, Jie Xiang, Zhengxin Xu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
nobiletin
arrhythmia
Na<sub>V</sub>1.5 channel
ventricular myocytes
amiodarone
aconitine
Online Access:https://www.mdpi.com/1422-0067/23/23/15175

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