Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats
Objectives:This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling.Methods:The rats were divided into three groups: Control group, pentylenetetrazol administered (PTZ) group, and PT...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2021-09-01
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| Series: | Archives of Epilepsy |
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http://archepilepsy.org/archives/archive-detail/article-preview/effects-of-cichorium-ntybus-on-gabaa-receptors-and/54627
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| author | Ozlem ERGUL ERKEC Ismail MERAL Mehmet KARA Mukaddes ESREFOGLU Olgu Enis TOK Savas USTUNOVA Metin ARMAGAN |
| author_facet | Ozlem ERGUL ERKEC Ismail MERAL Mehmet KARA Mukaddes ESREFOGLU Olgu Enis TOK Savas USTUNOVA Metin ARMAGAN |
| author_sort | Ozlem ERGUL ERKEC |
| collection | DOAJ |
| description | Objectives:This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling.Methods:The rats were divided into three groups: Control group, pentylenetetrazol administered (PTZ) group, and PTZ+CI extract administered (PTZ+CI) group. Control group received only physiological saline (0.5 ml). PTZ (35 mg/kg) injected to the animals in the PTZ and PTZ+CI groups. The CI extract (200 mg/kg) was also administered to the PTZ+CI group. A 75 mg/kg challenge dose of PTZ was administrated to the PTZ treated groups, on the 12th injection.Results:A significant increase was found in the number of neurons expressing the GABAA receptor in the brain tissue (hippocampus and cerebral cortex) of the PTZ group when compared to the control. The density of GABAA receptor of the neurons in the cerebral cortex significantly increased in PTZ administered groups compared to the control. The number of apoptotic neurons was found non-significant between groups in the brain.Conclusion:CI treatment prolonged the onset of the first seizure activity and seizure latency at a convulsive dose, and kept the number of GABAA receptors close to that of the control in the hippocampus. |
| first_indexed | 2024-03-12T20:39:20Z |
| format | Article |
| id | doaj.art-a05a403fe029489eb4576c740ccca40d |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:39:20Z |
| publishDate | 2021-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-a05a403fe029489eb4576c740ccca40d2023-08-01T11:12:41ZengGalenos YayineviArchives of Epilepsy2792-05502021-09-0127313113710.14744/epilepsi.2021.7983613049054Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in RatsOzlem ERGUL ERKEC0Ismail MERAL1Mehmet KARA2Mukaddes ESREFOGLU3Olgu Enis TOK4Savas USTUNOVA5Metin ARMAGAN6 Department of Physiology, Van Yuzuncu Yıl University Faculty of Medicine, Van, Turkey Department of Physiology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey Department of Physiology, Van Yuzuncu Yıl University Faculty of Medicine, Van, Turkey Department of Histology and Embryology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey Department of Histology and Embryology, Regenerative and Restorative Medicine Research Center, Istanbul Medipol University, Istanbul, Turkey Department of Physiology, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkey Medicinal and Aromatic Plants Program, Aydın Adnan Menderes University Buharkent Vocational School, Aydın, Turkey Objectives:This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABAA receptor density in the brains of rats in pentyleneterazole induced kindling.Methods:The rats were divided into three groups: Control group, pentylenetetrazol administered (PTZ) group, and PTZ+CI extract administered (PTZ+CI) group. Control group received only physiological saline (0.5 ml). PTZ (35 mg/kg) injected to the animals in the PTZ and PTZ+CI groups. The CI extract (200 mg/kg) was also administered to the PTZ+CI group. A 75 mg/kg challenge dose of PTZ was administrated to the PTZ treated groups, on the 12th injection.Results:A significant increase was found in the number of neurons expressing the GABAA receptor in the brain tissue (hippocampus and cerebral cortex) of the PTZ group when compared to the control. The density of GABAA receptor of the neurons in the cerebral cortex significantly increased in PTZ administered groups compared to the control. The number of apoptotic neurons was found non-significant between groups in the brain.Conclusion:CI treatment prolonged the onset of the first seizure activity and seizure latency at a convulsive dose, and kept the number of GABAA receptors close to that of the control in the hippocampus. http://archepilepsy.org/archives/archive-detail/article-preview/effects-of-cichorium-ntybus-on-gabaa-receptors-and/54627 brain cichorium intybusepilepsyhippocampuskindlingpentyleneterazoleseizure |
| spellingShingle | Ozlem ERGUL ERKEC Ismail MERAL Mehmet KARA Mukaddes ESREFOGLU Olgu Enis TOK Savas USTUNOVA Metin ARMAGAN Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats Archives of Epilepsy brain cichorium intybus epilepsy hippocampus kindling pentyleneterazole seizure |
| title | Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats |
| title_full | Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats |
| title_fullStr | Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats |
| title_full_unstemmed | Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats |
| title_short | Effects of Cichorium Intybus on GABAA Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats |
| title_sort | effects of cichorium intybus on gabaa receptors and apoptosis in pentylenetetrazole induced kindling in rats |
| topic | brain cichorium intybus epilepsy hippocampus kindling pentyleneterazole seizure |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/effects-of-cichorium-ntybus-on-gabaa-receptors-and/54627
|
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