Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Monoclonal antibodies (mAbs) and proteins containing antibody domains are the most prevalent class of biotherapeutics in diverse indication areas. Today, established techniques such as immunization or phage display allow for an efficient generation of new mAbs. Besides functional properties, the sta...

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Hlavní autoři: Jasmin F Sydow, Florian Lipsmeier, Vincent Larraillet, Maximiliane Hilger, Bjoern Mautz, Michael Mølhøj, Jan Kuentzer, Stefan Klostermann, Juergen Schoch, Hans R Voelger, Joerg T Regula, Patrick Cramer, Apollon Papadimitriou, Hubert Kettenberger
Médium: Článek
Jazyk:English
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC4069079?pdf=render

Internet

http://europepmc.org/articles/PMC4069079?pdf=render

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