Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status
Introduction: The effect of androgens on the cardiovascular system in humans is ambiguous. Moreover, still little is known about the effects of the most potent androgen, dihydrotestosterone, on arterial stiffness and endothelial function. The aim of this study was to evaluate whether age-dependent a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556523000256 |
| _version_ | 1827897317853757440 |
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| author | Marcin Grandys Joanna Majerczak Marzena Frolow Krystyna Sztefko Stefan Chlopicki Jerzy A. Zoladz |
| author_facet | Marcin Grandys Joanna Majerczak Marzena Frolow Krystyna Sztefko Stefan Chlopicki Jerzy A. Zoladz |
| author_sort | Marcin Grandys |
| collection | DOAJ |
| description | Introduction: The effect of androgens on the cardiovascular system in humans is ambiguous. Moreover, still little is known about the effects of the most potent androgen, dihydrotestosterone, on arterial stiffness and endothelial function. The aim of this study was to evaluate whether age-dependent alterations in serum concentration of dihydrotestosterone and its circulating metabolite are accompanied by changes in endothelial function and arterial stiffness. Methods: In 12 young and 11 older men, basal serum concentrations of testosterone, dehydroepiandrosterone sulfate (DHAE-S), androstenedione (AE), dihydrotestosterone (DHT) and androstanediol glucuronide (ADG) were analyzed in relation to vascular status including cIMT — carotid intima media thickness, cAI — central augmentation index, crPWV — carotid radial pulse wave velocity, SI — stiffness index, endothelial and inflammatory markers. Results: Although concentration of testosterone was not different between young and older group, it was demonstrated that DHT, DHEA-S, AE and ADG were significantly lower in older men in comparison to young men (p < 0.01). Interestingly the most surprising difference was found for DHT concentration, that was as much as 61 % lower in aged men that displayed significantly higher values of cIMT, AI, crPWV and SI (p < 10−4), suggestive of arterial stiffness. Furthermore, DHT was negatively correlated to all arterial wall parameters (cAI, crPWV, SI and cIMT), c-reactive protein (CRP) and hyaluronic acid (HA) concentration, as well as positively correlated to markers of endothelial function (MNA and 6-keto-PGF1α) in all studied individuals (n = 23). Conclusions: We have shown that ageing leads to a significant decrease in DHT concentration that is accompanied by impaired arterial wall characteristics and worsened endothelial function. Therefore more attention should be paid to the DHT, DHEA-S and ADG concentrations as a biomarkers for vascular dysfunction in ageing men. |
| first_indexed | 2024-03-12T22:47:24Z |
| format | Article |
| id | doaj.art-a05b276a585a4375b8e814dbefd65ade |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-12T22:47:24Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-a05b276a585a4375b8e814dbefd65ade2023-07-21T04:58:52ZengElsevierExperimental Gerontology1873-68152023-03-01173112104Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular statusMarcin Grandys0Joanna Majerczak1Marzena Frolow2Krystyna Sztefko3Stefan Chlopicki4Jerzy A. Zoladz5Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Ul. Skawinska 8, 31-066 Krakow, Poland; Corresponding authors.Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Ul. Skawinska 8, 31-066 Krakow, PolandJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Ul. Bobrzynskiego 14, 30-348 Krakow, PolandDepartment of Clinical Biochemistry of Pediatric Institute, Jagiellonian University Medical College, Ul. Wielicka 265, 30-663 Krakow, PolandJagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Ul. Bobrzynskiego 14, 30-348 Krakow, Poland; Department of Experimental Pharmacology, Chair of Pharmacology, Jagiellonian University Medical College, Ul. Grzegorzecka 16, 31-531 Krakow, PolandChair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Ul. Skawinska 8, 31-066 Krakow, Poland; Corresponding authors.Introduction: The effect of androgens on the cardiovascular system in humans is ambiguous. Moreover, still little is known about the effects of the most potent androgen, dihydrotestosterone, on arterial stiffness and endothelial function. The aim of this study was to evaluate whether age-dependent alterations in serum concentration of dihydrotestosterone and its circulating metabolite are accompanied by changes in endothelial function and arterial stiffness. Methods: In 12 young and 11 older men, basal serum concentrations of testosterone, dehydroepiandrosterone sulfate (DHAE-S), androstenedione (AE), dihydrotestosterone (DHT) and androstanediol glucuronide (ADG) were analyzed in relation to vascular status including cIMT — carotid intima media thickness, cAI — central augmentation index, crPWV — carotid radial pulse wave velocity, SI — stiffness index, endothelial and inflammatory markers. Results: Although concentration of testosterone was not different between young and older group, it was demonstrated that DHT, DHEA-S, AE and ADG were significantly lower in older men in comparison to young men (p < 0.01). Interestingly the most surprising difference was found for DHT concentration, that was as much as 61 % lower in aged men that displayed significantly higher values of cIMT, AI, crPWV and SI (p < 10−4), suggestive of arterial stiffness. Furthermore, DHT was negatively correlated to all arterial wall parameters (cAI, crPWV, SI and cIMT), c-reactive protein (CRP) and hyaluronic acid (HA) concentration, as well as positively correlated to markers of endothelial function (MNA and 6-keto-PGF1α) in all studied individuals (n = 23). Conclusions: We have shown that ageing leads to a significant decrease in DHT concentration that is accompanied by impaired arterial wall characteristics and worsened endothelial function. Therefore more attention should be paid to the DHT, DHEA-S and ADG concentrations as a biomarkers for vascular dysfunction in ageing men.http://www.sciencedirect.com/science/article/pii/S0531556523000256AndrogensSex steroidsEndotheliumCarotid artery intima-media thicknessCardiovascular risk |
| spellingShingle | Marcin Grandys Joanna Majerczak Marzena Frolow Krystyna Sztefko Stefan Chlopicki Jerzy A. Zoladz Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status Experimental Gerontology Androgens Sex steroids Endothelium Carotid artery intima-media thickness Cardiovascular risk |
| title | Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| title_full | Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| title_fullStr | Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| title_full_unstemmed | Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| title_short | Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| title_sort | age related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status |
| topic | Androgens Sex steroids Endothelium Carotid artery intima-media thickness Cardiovascular risk |
| url | http://www.sciencedirect.com/science/article/pii/S0531556523000256 |
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