Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease
Background and aim: Soluble CD40 ligand (sCD40L, also known as CD154) is a marker for platelet activation which could increase coagulation and inflammation. In this case-control study, we aimed to assess the levels of plasma sCD40L, IL-6, and some hemostatic parameters in patients with metabolic syn...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2011-09-01
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| Series: | The Egyptian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110260811000251 |
| _version_ | 1818926573016842240 |
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| author | Nader El-Shahhat Mahmoud M. Ramadan Nader El-Malkey Ashraf A. Omar Ibrahim A. Abd El-Aal Asmaa Eneen |
| author_facet | Nader El-Shahhat Mahmoud M. Ramadan Nader El-Malkey Ashraf A. Omar Ibrahim A. Abd El-Aal Asmaa Eneen |
| author_sort | Nader El-Shahhat |
| collection | DOAJ |
| description | Background and aim: Soluble CD40 ligand (sCD40L, also known as CD154) is a marker for platelet activation which could increase coagulation and inflammation. In this case-control study, we aimed to assess the levels of plasma sCD40L, IL-6, and some hemostatic parameters in patients with metabolic syndrome (MetS) whether or not associated with overt ischemic heart disease (IHD).
Subjects and methods: We measured plasma sCD40L (an index of platelet activation), interleukin (IL)-6 (a proinflammatory cytokine), and some hemostatic parameters (tissue factor [TF], thrombin–antithrombin [TAT] and D-dimer) in 47 patients with metabolic syndrome (21 with and 26 without overt IHD) versus 25 comparable healthy control subjects.
Results: Significantly higher levels of sCD40L, IL-6, and thrombotic markers (TF, D-dimer and TAT) were found in patients with metabolic syndrome compared to healthy controls. The levels of IL-6 and sCD40 were highest in patients with overt IHD. Strong positive correlations existed between sCD40L and IL-6 (r = 0.67, p = 0.003), TF (r = 0.59, p = 0.008), and platelets count (r = 0.64, p = 0.005).
Conclusion: Higher levels of sCD40L, IL-6, and thrombotic markers exist in MetS patients, particularly those with IHD. The strong positive correlations between sCD40L and IL-6, TF, and platelets count support a link between the CD40–CD40L system and the underlying inflammatory and hypercoagulable state in MetS patients. |
| first_indexed | 2024-12-20T02:59:16Z |
| format | Article |
| id | doaj.art-a05b59ea04194f358c47e81c699f31ef |
| institution | Directory Open Access Journal |
| issn | 1110-2608 |
| language | English |
| last_indexed | 2024-12-20T02:59:16Z |
| publishDate | 2011-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Heart Journal |
| spelling | doaj.art-a05b59ea04194f358c47e81c699f31ef2022-12-21T19:55:49ZengSpringerOpenThe Egyptian Heart Journal1110-26082011-09-0163313113510.1016/j.ehj.2011.08.024Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart diseaseNader El-Shahhat0Mahmoud M. Ramadan1Nader El-Malkey2Ashraf A. Omar3Ibrahim A. Abd El-Aal4Asmaa Eneen5Department of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Cardiology, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, EgyptDepartment of Internal Medicine, Faculty of Medicine, Mansoura University, EgyptBackground and aim: Soluble CD40 ligand (sCD40L, also known as CD154) is a marker for platelet activation which could increase coagulation and inflammation. In this case-control study, we aimed to assess the levels of plasma sCD40L, IL-6, and some hemostatic parameters in patients with metabolic syndrome (MetS) whether or not associated with overt ischemic heart disease (IHD). Subjects and methods: We measured plasma sCD40L (an index of platelet activation), interleukin (IL)-6 (a proinflammatory cytokine), and some hemostatic parameters (tissue factor [TF], thrombin–antithrombin [TAT] and D-dimer) in 47 patients with metabolic syndrome (21 with and 26 without overt IHD) versus 25 comparable healthy control subjects. Results: Significantly higher levels of sCD40L, IL-6, and thrombotic markers (TF, D-dimer and TAT) were found in patients with metabolic syndrome compared to healthy controls. The levels of IL-6 and sCD40 were highest in patients with overt IHD. Strong positive correlations existed between sCD40L and IL-6 (r = 0.67, p = 0.003), TF (r = 0.59, p = 0.008), and platelets count (r = 0.64, p = 0.005). Conclusion: Higher levels of sCD40L, IL-6, and thrombotic markers exist in MetS patients, particularly those with IHD. The strong positive correlations between sCD40L and IL-6, TF, and platelets count support a link between the CD40–CD40L system and the underlying inflammatory and hypercoagulable state in MetS patients.http://www.sciencedirect.com/science/article/pii/S1110260811000251Soluble CD40LIL-6HemostasisMetabolic syndromeIschemic heart disease |
| spellingShingle | Nader El-Shahhat Mahmoud M. Ramadan Nader El-Malkey Ashraf A. Omar Ibrahim A. Abd El-Aal Asmaa Eneen Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease The Egyptian Heart Journal Soluble CD40L IL-6 Hemostasis Metabolic syndrome Ischemic heart disease |
| title | Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| title_full | Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| title_fullStr | Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| title_full_unstemmed | Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| title_short | Soluble CD40 ligand, interleukin (IL)-6, and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| title_sort | soluble cd40 ligand interleukin il 6 and hemostatic parameters in metabolic syndrome patients with and without overt ischemic heart disease |
| topic | Soluble CD40L IL-6 Hemostasis Metabolic syndrome Ischemic heart disease |
| url | http://www.sciencedirect.com/science/article/pii/S1110260811000251 |
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