Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system
<p>Abstract</p> <p>Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membra...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-10-01
|
| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/7/1/114 |
| _version_ | 1828820762198278144 |
|---|---|
| author | Kesari Kavindra K Desai Nisarg R Agarwal Ashok |
| author_facet | Kesari Kavindra K Desai Nisarg R Agarwal Ashok |
| author_sort | Kesari Kavindra K |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central role in oxidative stress (OS) due to cell phone radiation (with a focus on the male reproductive system). This review also addresses: 1) the controversial effects of RF-EMW on mammalian cells and sperm DNA as well as its effect on apoptosis, 2) epidemiological, in vivo animal and in vitro studies on the effect of RF-EMW on male reproductive system, and 3) finally, exposure assessment and dosimetry by computational biomodeling.</p> |
| first_indexed | 2024-12-12T12:40:25Z |
| format | Article |
| id | doaj.art-a05d4ada5c4043df8c7382cf8d05a0ee |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-12T12:40:25Z |
| publishDate | 2009-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-a05d4ada5c4043df8c7382cf8d05a0ee2022-12-22T00:24:14ZengBMCReproductive Biology and Endocrinology1477-78272009-10-017111410.1186/1477-7827-7-114Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive systemKesari Kavindra KDesai Nisarg RAgarwal Ashok<p>Abstract</p> <p>Hazardous health effects stemming from exposure to radiofrequency electromagnetic waves (RF-EMW) emitted from cell phones have been reported in the literature. However, the cellular target of RF-EMW is still controversial. This review identifies the plasma membrane as a target of RF-EMW. In addition, the effects of RF-EMW on plasma membrane structures (i.e. NADH oxidase, phosphatidylserine, ornithine decarboxylase) and voltage-gated calcium channels are discussed. We explore the disturbance in reactive oxygen species (ROS) metabolism caused by RF-EMW and delineate NADH oxidase mediated ROS formation as playing a central role in oxidative stress (OS) due to cell phone radiation (with a focus on the male reproductive system). This review also addresses: 1) the controversial effects of RF-EMW on mammalian cells and sperm DNA as well as its effect on apoptosis, 2) epidemiological, in vivo animal and in vitro studies on the effect of RF-EMW on male reproductive system, and 3) finally, exposure assessment and dosimetry by computational biomodeling.</p>http://www.rbej.com/content/7/1/114 |
| spellingShingle | Kesari Kavindra K Desai Nisarg R Agarwal Ashok Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system Reproductive Biology and Endocrinology |
| title | Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system |
| title_full | Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system |
| title_fullStr | Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system |
| title_full_unstemmed | Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system |
| title_short | Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system |
| title_sort | pathophysiology of cell phone radiation oxidative stress and carcinogenesis with focus on male reproductive system |
| url | http://www.rbej.com/content/7/1/114 |
| work_keys_str_mv | AT kesarikavindrak pathophysiologyofcellphoneradiationoxidativestressandcarcinogenesiswithfocusonmalereproductivesystem AT desainisargr pathophysiologyofcellphoneradiationoxidativestressandcarcinogenesiswithfocusonmalereproductivesystem AT agarwalashok pathophysiologyofcellphoneradiationoxidativestressandcarcinogenesiswithfocusonmalereproductivesystem |