Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report
Abstract Background The finding of hematological malignancies within bone marrow in heterotopic ossification has been reported only a handful of times previously in the literature. We described a case of true trilineage hematopoiesis in an excised area of heterotopic ossification from an enucleated...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-07-01
|
| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-020-02430-9 |
| _version_ | 1818041512393441280 |
|---|---|
| author | Alfredo Borgia Sofia Manara Monica Balzarotti Paolo Vinciguerra Alessandra Di Maria |
| author_facet | Alfredo Borgia Sofia Manara Monica Balzarotti Paolo Vinciguerra Alessandra Di Maria |
| author_sort | Alfredo Borgia |
| collection | DOAJ |
| description | Abstract Background The finding of hematological malignancies within bone marrow in heterotopic ossification has been reported only a handful of times previously in the literature. We described a case of true trilineage hematopoiesis in an excised area of heterotopic ossification from an enucleated blind painful eye. Case presentation A 70-year-old Caucasian man, positive for asymptomatic lymphoplasmacytic lymphoma, presented with a blind painful right eye in our ophthalmology department to evaluate enucleation bulbi. After enucleation, a histopathologic examination revealed the presence of intertrabecular infiltration in the metaplastic bone marrow of non-Hodgkin B lymphoma, with small lymphocytes, with similar characteristics to the already known disease. Conclusion This uncommon case reveals the possibility of the localization of malignant cells within bone metaplasia of intraocular ossification in an enucleated blind painful eye. From a practical point of view, a careful systematic histopathological examination of all resected tissues in patients with a history of malignant neoplastic pathology is necessary to confirm the diagnosis and exclude occult malignancies. |
| first_indexed | 2024-12-10T08:31:36Z |
| format | Article |
| id | doaj.art-a05f5389e530451bb45056e96b9fecb5 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-10T08:31:36Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-a05f5389e530451bb45056e96b9fecb52022-12-22T01:56:05ZengBMCJournal of Medical Case Reports1752-19472020-07-011411410.1186/s13256-020-02430-9Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case reportAlfredo Borgia0Sofia Manara1Monica Balzarotti2Paolo Vinciguerra3Alessandra Di Maria4Humanitas University, Department of Biomedical SciencesHumanitas Clinical and Research Center – IRCCSHumanitas Clinical and Research Center – IRCCSHumanitas University, Department of Biomedical SciencesHumanitas University, Department of Biomedical SciencesAbstract Background The finding of hematological malignancies within bone marrow in heterotopic ossification has been reported only a handful of times previously in the literature. We described a case of true trilineage hematopoiesis in an excised area of heterotopic ossification from an enucleated blind painful eye. Case presentation A 70-year-old Caucasian man, positive for asymptomatic lymphoplasmacytic lymphoma, presented with a blind painful right eye in our ophthalmology department to evaluate enucleation bulbi. After enucleation, a histopathologic examination revealed the presence of intertrabecular infiltration in the metaplastic bone marrow of non-Hodgkin B lymphoma, with small lymphocytes, with similar characteristics to the already known disease. Conclusion This uncommon case reveals the possibility of the localization of malignant cells within bone metaplasia of intraocular ossification in an enucleated blind painful eye. From a practical point of view, a careful systematic histopathological examination of all resected tissues in patients with a history of malignant neoplastic pathology is necessary to confirm the diagnosis and exclude occult malignancies.http://link.springer.com/article/10.1186/s13256-020-02430-9Intraocular heterotopic ossificationExtramedullary hematopoiesisSmall lymphocytic lymphoma |
| spellingShingle | Alfredo Borgia Sofia Manara Monica Balzarotti Paolo Vinciguerra Alessandra Di Maria Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report Journal of Medical Case Reports Intraocular heterotopic ossification Extramedullary hematopoiesis Small lymphocytic lymphoma |
| title | Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report |
| title_full | Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report |
| title_fullStr | Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report |
| title_full_unstemmed | Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report |
| title_short | Small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye: a case report |
| title_sort | small lymphocytic lymphoma in true trilineage hematopoietic tissue within heterotopic ossification in an enucleated blind painful eye a case report |
| topic | Intraocular heterotopic ossification Extramedullary hematopoiesis Small lymphocytic lymphoma |
| url | http://link.springer.com/article/10.1186/s13256-020-02430-9 |
| work_keys_str_mv | AT alfredoborgia smalllymphocyticlymphomaintruetrilineagehematopoietictissuewithinheterotopicossificationinanenucleatedblindpainfuleyeacasereport AT sofiamanara smalllymphocyticlymphomaintruetrilineagehematopoietictissuewithinheterotopicossificationinanenucleatedblindpainfuleyeacasereport AT monicabalzarotti smalllymphocyticlymphomaintruetrilineagehematopoietictissuewithinheterotopicossificationinanenucleatedblindpainfuleyeacasereport AT paolovinciguerra smalllymphocyticlymphomaintruetrilineagehematopoietictissuewithinheterotopicossificationinanenucleatedblindpainfuleyeacasereport AT alessandradimaria smalllymphocyticlymphomaintruetrilineagehematopoietictissuewithinheterotopicossificationinanenucleatedblindpainfuleyeacasereport |