Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children
Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in th...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-09-01
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| Series: | The Egyptian Journal of Bronchology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43168-020-00029-8 |
| _version_ | 1819028839742832640 |
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| author | Bankole Peter Kuti Alex Ifeoluwa Akinwumi Demilade Kehinde Kuti Kazeem Olanrewaju Amoo |
| author_facet | Bankole Peter Kuti Alex Ifeoluwa Akinwumi Demilade Kehinde Kuti Kazeem Olanrewaju Amoo |
| author_sort | Bankole Peter Kuti |
| collection | DOAJ |
| description | Abstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children. |
| first_indexed | 2024-12-21T06:04:45Z |
| format | Article |
| id | doaj.art-a0610bc44a3e462fa8a9285ac11b2edc |
| institution | Directory Open Access Journal |
| issn | 1687-8426 2314-8551 |
| language | English |
| last_indexed | 2024-12-21T06:04:45Z |
| publishDate | 2020-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Bronchology |
| spelling | doaj.art-a0610bc44a3e462fa8a9285ac11b2edc2022-12-21T19:13:41ZengSpringerOpenThe Egyptian Journal of Bronchology1687-84262314-85512020-09-0114111010.1186/s43168-020-00029-8Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian childrenBankole Peter Kuti0Alex Ifeoluwa Akinwumi1Demilade Kehinde Kuti2Kazeem Olanrewaju Amoo3Department of Paediatrics and Child Health, Obafemi Awolowo UniversityDepartment of Paediatrics, Wesley Guild HospitalDepartment of Paediatrics, Wesley Guild HospitalDepartment of Paediatrics, Wesley Guild HospitalAbstract Background The pathologic basis of childhood community-acquired pneumonia (CAP) involves the generation of reactive oxygen species by immune cells leading to cellular damage and lung congestion. Serum antioxidants and vitamin D with immunomodulatory properties therefore hold prospects in the prevention and management of pneumonia in children. This case–control study set out to compare the serum 25-hydroxyvitamin D (25-OHD) and total antioxidant capacity (TAC) in Nigerian children with CAP and age- and sex-matched controls and to relate these parameters with pneumonia severity and outcome—length of hospital stay (LOH). Results A total of 160 children (80 each for CAP and controls) were recruited. The median (IQR) age was 1.8 (0.6–4.0) years, male:female 1.7:1, 63 (78.8%) and 11 (13.8%) of CAP group had severe pneumonia and parapneumonic effusions, respectively. Serum 25-OHD (33.8 (18.3) ng/ml vs. 41.9 (12.3) ng/ml; p = 0.010) and TAC (6.1 (4.4–8.1) ng/dl vs. 7.2 (4.7–17.5) ng/dl; p = 0.023) were lower in children with CAP than controls. Lower serum 25-OHD was observed in severe than non-severe pneumonia (30.5(17.1) ng/ml vs. 46.3 (17.6) ng/ml; p = 0.001) but LOH did not correlate with serum 25-OHD and TAC. Conclusion Children with CAP had lower serum vitamin D and antioxidants than controls, and severe pneumonia was significantly associated with suboptimal serum vitamin D. They however were not related to pneumonia outcome. Optimal serum vitamin D and antioxidants may play a role in reducing the incidence of childhood CAP in Nigerian children.http://link.springer.com/article/10.1186/s43168-020-00029-8Childhood pneumoniaVitamin DAntioxidantsOutcomeHospitalisation |
| spellingShingle | Bankole Peter Kuti Alex Ifeoluwa Akinwumi Demilade Kehinde Kuti Kazeem Olanrewaju Amoo Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children The Egyptian Journal of Bronchology Childhood pneumonia Vitamin D Antioxidants Outcome Hospitalisation |
| title | Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children |
| title_full | Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children |
| title_fullStr | Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children |
| title_full_unstemmed | Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children |
| title_short | Relationship between serum 25-hydroxyvitamin D, total antioxidant capacity and pneumonia incidence, severity and outcome in Nigerian children |
| title_sort | relationship between serum 25 hydroxyvitamin d total antioxidant capacity and pneumonia incidence severity and outcome in nigerian children |
| topic | Childhood pneumonia Vitamin D Antioxidants Outcome Hospitalisation |
| url | http://link.springer.com/article/10.1186/s43168-020-00029-8 |
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