Tissue-resident memory T cells in renal autoimmune diseases
The discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain long-term and differentiate to TRM cells after...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111521/full |
| _version_ | 1797945484473532416 |
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| author | Pauline Ginsberg Ulf Panzer Nariaki Asada |
| author_facet | Pauline Ginsberg Ulf Panzer Nariaki Asada |
| author_sort | Pauline Ginsberg |
| collection | DOAJ |
| description | The discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain long-term and differentiate to TRM cells after antigen clearance. This allows for prompt immunological responses upon antigen re-encounter. In addition to their protective properties in acute infections, recent studies have revealed that TRM cells might lead to aggravation of autoimmune diseases, such as lupus nephritis (LN) and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). These diseases present as proliferative and crescentic glomerulonephritis (cGN), which is a life-threatening condition leading to end-stage renal disease (ESRD) if left untreated. A better understanding of renal TRM cells might lead to identifying new therapeutic targets for relapsing autoimmune diseases of the kidney. In this review, we summarize the current knowledge of renal TRM cells and discuss their potential pathophysiological roles in renal autoimmune diseases. |
| first_indexed | 2024-04-10T20:55:51Z |
| format | Article |
| id | doaj.art-a061b1af5c04485b8bc3ba7dc84e0d24 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T20:55:51Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-a061b1af5c04485b8bc3ba7dc84e0d242023-01-23T06:00:58ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011410.3389/fimmu.2023.11115211111521Tissue-resident memory T cells in renal autoimmune diseasesPauline GinsbergUlf PanzerNariaki AsadaThe discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain long-term and differentiate to TRM cells after antigen clearance. This allows for prompt immunological responses upon antigen re-encounter. In addition to their protective properties in acute infections, recent studies have revealed that TRM cells might lead to aggravation of autoimmune diseases, such as lupus nephritis (LN) and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). These diseases present as proliferative and crescentic glomerulonephritis (cGN), which is a life-threatening condition leading to end-stage renal disease (ESRD) if left untreated. A better understanding of renal TRM cells might lead to identifying new therapeutic targets for relapsing autoimmune diseases of the kidney. In this review, we summarize the current knowledge of renal TRM cells and discuss their potential pathophysiological roles in renal autoimmune diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111521/fulltissue-resident memory T cellrenal autoimmune diseasecrescentic glomerulonephritislupus nephritisANCA-associated glomerulonephritis |
| spellingShingle | Pauline Ginsberg Ulf Panzer Nariaki Asada Tissue-resident memory T cells in renal autoimmune diseases Frontiers in Immunology tissue-resident memory T cell renal autoimmune disease crescentic glomerulonephritis lupus nephritis ANCA-associated glomerulonephritis |
| title | Tissue-resident memory T cells in renal autoimmune diseases |
| title_full | Tissue-resident memory T cells in renal autoimmune diseases |
| title_fullStr | Tissue-resident memory T cells in renal autoimmune diseases |
| title_full_unstemmed | Tissue-resident memory T cells in renal autoimmune diseases |
| title_short | Tissue-resident memory T cells in renal autoimmune diseases |
| title_sort | tissue resident memory t cells in renal autoimmune diseases |
| topic | tissue-resident memory T cell renal autoimmune disease crescentic glomerulonephritis lupus nephritis ANCA-associated glomerulonephritis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111521/full |
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