Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model
Abstract Fluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility of longitudinal bioelectrical impedance analysis during fluid treatment, a preclin...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-12-01
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| Series: | Intensive Care Medicine Experimental |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40635-022-00480-5 |
| _version_ | 1811188226386296832 |
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| author | Hwain Jeong Inwon Park Jae Hyuk Lee Dongsung Kim Sumin Baek Seonghye Kim You Hwan Jo |
| author_facet | Hwain Jeong Inwon Park Jae Hyuk Lee Dongsung Kim Sumin Baek Seonghye Kim You Hwan Jo |
| author_sort | Hwain Jeong |
| collection | DOAJ |
| description | Abstract Fluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility of longitudinal bioelectrical impedance analysis during fluid treatment, a preclinical porcine model of Escherichia coli-induced sepsis was used. After sepsis induction, pigs were treated with fluid and vasopressors and monitored for up to 12 h after bacterial infusion or until death. Bipolar electrodes for bioelectrical impedance analysis were attached to the left extremities and measurements were performed every 10 min. Among the 12 subjects, 7 pigs expired during the experiment, and the median survival was 9.5 h. As sepsis progressed with an increase in cumulative fluid balance, R0 [∝ 1/extracellular water (ECW)] decreased, while R i [∝ 1/intracellular water (ICW)] and ratio of extracellular water to total body water (ECW/TBW) increased. The phase angle constantly decreased throughout the monitoring period, and all non-survivors died when the phase angle decreased by more than 10%. Among the variables, ΔR 0 and Δphase angle showed moderate negative correlations, and ΔECW/TBW showed a moderate positive correlation with the hourly fluid balance. Compared to survivors, a greater increase in ΔECW/TBW and a decrease in phase angle were observed in non-survivors over time, with an increase in cumulative fluid balance. Differences in ΔECW/TBW and phase angle emerged at 240 min when the difference in cumulative fluid balance between the two groups (survivors vs non-survivors) exceeded 1000 mL. In conclusion, continuous measurements of bioelectrical impedance analysis in a porcine sepsis model are feasible and may reflect changes in the body water profile during fluid resuscitation. |
| first_indexed | 2024-04-11T14:16:43Z |
| format | Article |
| id | doaj.art-a0633b2215ed4aa59c274f746ebd4629 |
| institution | Directory Open Access Journal |
| issn | 2197-425X |
| language | English |
| last_indexed | 2024-04-11T14:16:43Z |
| publishDate | 2022-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Intensive Care Medicine Experimental |
| spelling | doaj.art-a0633b2215ed4aa59c274f746ebd46292022-12-22T04:19:23ZengSpringerOpenIntensive Care Medicine Experimental2197-425X2022-12-0110111310.1186/s40635-022-00480-5Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis modelHwain Jeong0Inwon Park1Jae Hyuk Lee2Dongsung Kim3Sumin Baek4Seonghye Kim5You Hwan Jo6Department of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalDepartment of Emergency Medicine, Seoul National University Bundang HospitalAbstract Fluid resuscitation is crucial in the initial management of sepsis; however, little is known about the serial changes and overall distribution of fluids administered into the body. To identify the feasibility of longitudinal bioelectrical impedance analysis during fluid treatment, a preclinical porcine model of Escherichia coli-induced sepsis was used. After sepsis induction, pigs were treated with fluid and vasopressors and monitored for up to 12 h after bacterial infusion or until death. Bipolar electrodes for bioelectrical impedance analysis were attached to the left extremities and measurements were performed every 10 min. Among the 12 subjects, 7 pigs expired during the experiment, and the median survival was 9.5 h. As sepsis progressed with an increase in cumulative fluid balance, R0 [∝ 1/extracellular water (ECW)] decreased, while R i [∝ 1/intracellular water (ICW)] and ratio of extracellular water to total body water (ECW/TBW) increased. The phase angle constantly decreased throughout the monitoring period, and all non-survivors died when the phase angle decreased by more than 10%. Among the variables, ΔR 0 and Δphase angle showed moderate negative correlations, and ΔECW/TBW showed a moderate positive correlation with the hourly fluid balance. Compared to survivors, a greater increase in ΔECW/TBW and a decrease in phase angle were observed in non-survivors over time, with an increase in cumulative fluid balance. Differences in ΔECW/TBW and phase angle emerged at 240 min when the difference in cumulative fluid balance between the two groups (survivors vs non-survivors) exceeded 1000 mL. In conclusion, continuous measurements of bioelectrical impedance analysis in a porcine sepsis model are feasible and may reflect changes in the body water profile during fluid resuscitation.https://doi.org/10.1186/s40635-022-00480-5SepsisElectric impedanceBody fluid compartmentsFluid therapyFluid shifts |
| spellingShingle | Hwain Jeong Inwon Park Jae Hyuk Lee Dongsung Kim Sumin Baek Seonghye Kim You Hwan Jo Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model Intensive Care Medicine Experimental Sepsis Electric impedance Body fluid compartments Fluid therapy Fluid shifts |
| title | Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| title_full | Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| title_fullStr | Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| title_full_unstemmed | Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| title_short | Feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| title_sort | feasibility study using longitudinal bioelectrical impedance analysis to evaluate body water status during fluid resuscitation in a swine sepsis model |
| topic | Sepsis Electric impedance Body fluid compartments Fluid therapy Fluid shifts |
| url | https://doi.org/10.1186/s40635-022-00480-5 |
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