Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis
Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is an auto-inflammatory disease characterized by fever, arthritis, and ≥1 of rash, generalized lymphadenopathy, hepato/splenomegaly, and serositis. Non-steroidal anti-inflammatory drugs (NSAIDs) are among the initial treatments of sJI...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Pediatric Rheumatology Online Journal |
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| Online Access: | http://link.springer.com/article/10.1186/s12969-017-0219-4 |
| _version_ | 1818033824450215936 |
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| author | Anjali Sura Christopher Failing Julie Sturza Jasmine Stannard Meredith Riebschleger |
| author_facet | Anjali Sura Christopher Failing Julie Sturza Jasmine Stannard Meredith Riebschleger |
| author_sort | Anjali Sura |
| collection | DOAJ |
| description | Abstract Background Systemic juvenile idiopathic arthritis (sJIA) is an auto-inflammatory disease characterized by fever, arthritis, and ≥1 of rash, generalized lymphadenopathy, hepato/splenomegaly, and serositis. Non-steroidal anti-inflammatory drugs (NSAIDs) are among the initial treatments of sJIA, but there is currently no evidence indicating which children should undergo a trial of NSAID monotherapy and which should not. Our objective is to identify presentation characteristics which are associated with response and lack of response to a trial of NSAID monotherapy. Methods This is a retrospective single-center cohort study of children diagnosed with sJIA from 2000 to 2014. Patient demographics and disease characteristics were investigated to identify predictors of response to NSAID monotherapy. Results Eighty-seven children were newly diagnosed with sJIA 2000-2014. Thirteen of the 51 children who received NSAID monotherapy achieved clinically inactive disease (CID) without other medications. Age at presentation (≤8 years old), initial joint count (≤5), and C-reactive protein (CRP) (≤13 mg/dL) at diagnosis were associated with achievement of CID on NSAIDs alone. Physicians were less likely to trial NSAID monotherapy if the patient had either serositis or macrophage activation syndrome (MAS) at diagnosis. Ultimate achievement of CID and time to CID were not significantly affected by whether the patient received a trial of NSAID monotherapy. Conclusions While a subset of children with sJIA can achieve CID with NSAID monotherapy, we recommend against a trial in patients who are >8 years old, with >5 joints involved, or with CRP > 13 mg/dL. Patients who undergo a trial of NSAID monotherapy should follow up within 2-4 weeks to evaluate for possible need for drug escalation. Clinical trials are necessary to confirm these findings. |
| first_indexed | 2024-12-10T06:29:24Z |
| format | Article |
| id | doaj.art-a063b2c10e2c42c3a87985c3ab32d9f8 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-10T06:29:24Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-a063b2c10e2c42c3a87985c3ab32d9f82022-12-22T01:59:07ZengBMCPediatric Rheumatology Online Journal1546-00962018-01-011611610.1186/s12969-017-0219-4Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritisAnjali Sura0Christopher Failing1Julie Sturza2Jasmine Stannard3Meredith Riebschleger4University of MichiganUniversity of MichiganUniversity of MichiganIHA Rheumatology ConsultantsUniversity of MichiganAbstract Background Systemic juvenile idiopathic arthritis (sJIA) is an auto-inflammatory disease characterized by fever, arthritis, and ≥1 of rash, generalized lymphadenopathy, hepato/splenomegaly, and serositis. Non-steroidal anti-inflammatory drugs (NSAIDs) are among the initial treatments of sJIA, but there is currently no evidence indicating which children should undergo a trial of NSAID monotherapy and which should not. Our objective is to identify presentation characteristics which are associated with response and lack of response to a trial of NSAID monotherapy. Methods This is a retrospective single-center cohort study of children diagnosed with sJIA from 2000 to 2014. Patient demographics and disease characteristics were investigated to identify predictors of response to NSAID monotherapy. Results Eighty-seven children were newly diagnosed with sJIA 2000-2014. Thirteen of the 51 children who received NSAID monotherapy achieved clinically inactive disease (CID) without other medications. Age at presentation (≤8 years old), initial joint count (≤5), and C-reactive protein (CRP) (≤13 mg/dL) at diagnosis were associated with achievement of CID on NSAIDs alone. Physicians were less likely to trial NSAID monotherapy if the patient had either serositis or macrophage activation syndrome (MAS) at diagnosis. Ultimate achievement of CID and time to CID were not significantly affected by whether the patient received a trial of NSAID monotherapy. Conclusions While a subset of children with sJIA can achieve CID with NSAID monotherapy, we recommend against a trial in patients who are >8 years old, with >5 joints involved, or with CRP > 13 mg/dL. Patients who undergo a trial of NSAID monotherapy should follow up within 2-4 weeks to evaluate for possible need for drug escalation. Clinical trials are necessary to confirm these findings.http://link.springer.com/article/10.1186/s12969-017-0219-4Systemic juvenile idiopathic arthritis (sJIA)Non-steroidal anti-inflammatory drugs (NSAIDs)NSAID monotherapyTherapeuticsRisk stratification |
| spellingShingle | Anjali Sura Christopher Failing Julie Sturza Jasmine Stannard Meredith Riebschleger Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis Pediatric Rheumatology Online Journal Systemic juvenile idiopathic arthritis (sJIA) Non-steroidal anti-inflammatory drugs (NSAIDs) NSAID monotherapy Therapeutics Risk stratification |
| title | Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis |
| title_full | Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis |
| title_fullStr | Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis |
| title_full_unstemmed | Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis |
| title_short | Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis |
| title_sort | patient characteristics associated with response to nsaid monotherapy in children with systemic juvenile idiopathic arthritis |
| topic | Systemic juvenile idiopathic arthritis (sJIA) Non-steroidal anti-inflammatory drugs (NSAIDs) NSAID monotherapy Therapeutics Risk stratification |
| url | http://link.springer.com/article/10.1186/s12969-017-0219-4 |
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