Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients
Oxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzy-matic antioxidants. Thirty-one HD...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2012;volume=23;issue=2;spage=274;epage=279;aulast=Montazerifar |
| _version_ | 1811304071199457280 |
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| author | Farzaneh Montazerifar Mohammad Hashemi Mansour Karajibani Houshang Sanadgol Madhurima Dikshit |
| author_facet | Farzaneh Montazerifar Mohammad Hashemi Mansour Karajibani Houshang Sanadgol Madhurima Dikshit |
| author_sort | Farzaneh Montazerifar |
| collection | DOAJ |
| description | Oxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzy-matic antioxidants. Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled. The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects. In addition, SOD and GPx activities significantly decreased and MDA increased after HD. We also found that there was a significantly negative correlation between SOD and GPx with MDA. The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications. |
| first_indexed | 2024-04-13T07:59:25Z |
| format | Article |
| id | doaj.art-a06432739e6845028ef6dad7176cdbae |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-13T07:59:25Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-a06432739e6845028ef6dad7176cdbae2022-12-22T02:55:19ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422012-01-0123227427910.4103/1319-2442.93151Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patientsFarzaneh MontazerifarMohammad HashemiMansour KarajibaniHoushang SanadgolMadhurima DikshitOxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzy-matic antioxidants. Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled. The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects. In addition, SOD and GPx activities significantly decreased and MDA increased after HD. We also found that there was a significantly negative correlation between SOD and GPx with MDA. The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2012;volume=23;issue=2;spage=274;epage=279;aulast=Montazerifar |
| spellingShingle | Farzaneh Montazerifar Mohammad Hashemi Mansour Karajibani Houshang Sanadgol Madhurima Dikshit Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients Saudi Journal of Kidney Diseases and Transplantation |
| title | Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| title_full | Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| title_fullStr | Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| title_full_unstemmed | Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| title_short | Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| title_sort | evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2012;volume=23;issue=2;spage=274;epage=279;aulast=Montazerifar |
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