Does cotinine act upon reactive oxygen species and peroxidases?
Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of ox...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Estadual Paulista
2018-03-01
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| Series: | Eclética Química |
| Online Access: | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/354 |
| _version_ | 1818933026193670144 |
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| author | José Carlos Rebuglio Vellosa Najeh Maissar Khalil Luiz Marcos da Fonseca Iguatemy Lourenço Brunetti Olga Maria Mascarenhas de Faria Oliveira |
| author_facet | José Carlos Rebuglio Vellosa Najeh Maissar Khalil Luiz Marcos da Fonseca Iguatemy Lourenço Brunetti Olga Maria Mascarenhas de Faria Oliveira |
| author_sort | José Carlos Rebuglio Vellosa |
| collection | DOAJ |
| description | Nicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world.
It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of
tobacco is closely associated with lung disease, morphological leukocyte modification and generation
of oxidant species. The aim of this study was to look for a possible relationship between cotinine,
oxidant species generation and oxidative processes. After studying the action of cotinine in some
chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and
horseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurine
chloramines, horseradish peroxidase or myeloperoxidase. |
| first_indexed | 2024-12-20T04:41:50Z |
| format | Article |
| id | doaj.art-a064fcf4f740427883798e8608c188e0 |
| institution | Directory Open Access Journal |
| issn | 1678-4618 |
| language | English |
| last_indexed | 2024-12-20T04:41:50Z |
| publishDate | 2018-03-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Eclética Química |
| spelling | doaj.art-a064fcf4f740427883798e8608c188e02022-12-21T19:53:06ZengUniversidade Estadual PaulistaEclética Química1678-46182018-03-01321657010.26850/1678-4618eqj.v32.1.2007.p65-70354Does cotinine act upon reactive oxygen species and peroxidases?José Carlos Rebuglio Vellosa0Najeh Maissar Khalil1Luiz Marcos da Fonseca2Iguatemy Lourenço Brunetti3Olga Maria Mascarenhas de Faria Oliveira4UNESP - Sao Paulo State University, Biochemistry and Technological Chemistry Department, Chemistry Institute, Araraquara-SP, Brazil UNESP - Sao Paulo State University, Clinical Analysis Department, School of Pharmaceutical Sciences, Araraquara-SP, Brazil State University of Ponta GrossaUniversidade Estadual do Centro-Oeste do Paraná (UNICENTRO)UNESP - Sao Paulo State University, Clinical Analysis Department, School of Pharmaceutical Sciences, Araraquara-SP, BrazilUNESP - Sao Paulo State University, Clinical Analysis Department, School of Pharmaceutical Sciences, Araraquara-SP, BrazilUNESP - Sao Paulo State University, Biochemistry and Technological Chemistry Department, Chemistry Institute, Araraquara-SP, BrazilNicotine, an oxidizing agent, is certainly one of the most widely used alkaloids in the world. It is, together with its main metabolite, cotinine, responsible for tobacco-dependence. The use of tobacco is closely associated with lung disease, morphological leukocyte modification and generation of oxidant species. The aim of this study was to look for a possible relationship between cotinine, oxidant species generation and oxidative processes. After studying the action of cotinine in some chemical oxidation models and on the enzymatic kinetics of peroxidases (myeloperoxidase and horseradish peroxidase), we concluded that cotinine does not act directly upon H2O2, HOCl, taurine chloramines, horseradish peroxidase or myeloperoxidase.https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/354 |
| spellingShingle | José Carlos Rebuglio Vellosa Najeh Maissar Khalil Luiz Marcos da Fonseca Iguatemy Lourenço Brunetti Olga Maria Mascarenhas de Faria Oliveira Does cotinine act upon reactive oxygen species and peroxidases? Eclética Química |
| title | Does cotinine act upon reactive oxygen species and peroxidases? |
| title_full | Does cotinine act upon reactive oxygen species and peroxidases? |
| title_fullStr | Does cotinine act upon reactive oxygen species and peroxidases? |
| title_full_unstemmed | Does cotinine act upon reactive oxygen species and peroxidases? |
| title_short | Does cotinine act upon reactive oxygen species and peroxidases? |
| title_sort | does cotinine act upon reactive oxygen species and peroxidases |
| url | https://revista.iq.unesp.br/ojs/index.php/ecletica/article/view/354 |
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