Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases
Autophagy is essential for the maintenance of hepatic homeostasis, and autophagic malfunction has been linked to the pathogenesis of substantial liver diseases. As a popular source of drug discovery, natural products have been used for centuries to effectively prevent the progression of various live...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/23/15109 |
| _version_ | 1797463090045911040 |
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| author | Guifang Fan Fanghong Li Ping Wang Xuejing Jin Runping Liu |
| author_facet | Guifang Fan Fanghong Li Ping Wang Xuejing Jin Runping Liu |
| author_sort | Guifang Fan |
| collection | DOAJ |
| description | Autophagy is essential for the maintenance of hepatic homeostasis, and autophagic malfunction has been linked to the pathogenesis of substantial liver diseases. As a popular source of drug discovery, natural products have been used for centuries to effectively prevent the progression of various liver diseases. Emerging evidence has suggested that autophagy regulation is a critical mechanism underlying the therapeutic effects of these natural products. In this review, relevant studies are retrieved from scientific databases published between 2011 and 2022, and a novel scoring system was established to critically evaluate the completeness and scientific significance of the reviewed literature. We observed that numerous natural products were suggested to regulate autophagic flux. Depending on the therapeutic or pathogenic role autophagy plays in different liver diseases, autophagy-regulative natural products exhibit different therapeutic effects. According to our novel scoring system, in a considerable amount of the involved studies, convincing and reasonable evidence to elucidate the regulatory effects and underlying mechanisms of natural-product-mediated autophagy regulation was missing and needed further illustration. We highlight that autophagy-regulative natural products are valuable drug candidates with promising prospects for the treatment of liver diseases and deserve more attention in the future. |
| first_indexed | 2024-03-09T17:45:42Z |
| format | Article |
| id | doaj.art-a06513afc91a40c9b7ccd8b2f562e94c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T17:45:42Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-a06513afc91a40c9b7ccd8b2f562e94c2023-11-24T11:13:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-12-0123231510910.3390/ijms232315109Natural-Product-Mediated Autophagy in the Treatment of Various Liver DiseasesGuifang Fan0Fanghong Li1Ping Wang2Xuejing Jin3Runping Liu4School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, ChinaCenter for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, ChinaCenter for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing 100029, ChinaAutophagy is essential for the maintenance of hepatic homeostasis, and autophagic malfunction has been linked to the pathogenesis of substantial liver diseases. As a popular source of drug discovery, natural products have been used for centuries to effectively prevent the progression of various liver diseases. Emerging evidence has suggested that autophagy regulation is a critical mechanism underlying the therapeutic effects of these natural products. In this review, relevant studies are retrieved from scientific databases published between 2011 and 2022, and a novel scoring system was established to critically evaluate the completeness and scientific significance of the reviewed literature. We observed that numerous natural products were suggested to regulate autophagic flux. Depending on the therapeutic or pathogenic role autophagy plays in different liver diseases, autophagy-regulative natural products exhibit different therapeutic effects. According to our novel scoring system, in a considerable amount of the involved studies, convincing and reasonable evidence to elucidate the regulatory effects and underlying mechanisms of natural-product-mediated autophagy regulation was missing and needed further illustration. We highlight that autophagy-regulative natural products are valuable drug candidates with promising prospects for the treatment of liver diseases and deserve more attention in the future.https://www.mdpi.com/1422-0067/23/23/15109natural productsautophagyliver diseasespharmacodynamicsscoring system |
| spellingShingle | Guifang Fan Fanghong Li Ping Wang Xuejing Jin Runping Liu Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases International Journal of Molecular Sciences natural products autophagy liver diseases pharmacodynamics scoring system |
| title | Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases |
| title_full | Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases |
| title_fullStr | Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases |
| title_full_unstemmed | Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases |
| title_short | Natural-Product-Mediated Autophagy in the Treatment of Various Liver Diseases |
| title_sort | natural product mediated autophagy in the treatment of various liver diseases |
| topic | natural products autophagy liver diseases pharmacodynamics scoring system |
| url | https://www.mdpi.com/1422-0067/23/23/15109 |
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