Reference compounds for characterizing cellular injury in high-content cellular morphology assays
Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with compound-dependent cellular injury and nuisance a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36829-x |
| _version_ | 1797864154425458688 |
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| author | Jayme L. Dahlin Bruce K. Hua Beth E. Zucconi Shawn D. Nelson Shantanu Singh Anne E. Carpenter Jonathan H. Shrimp Evelyne Lima-Fernandes Mathias J. Wawer Lawrence P. W. Chung Ayushi Agrawal Mary O’Reilly Dalia Barsyte-Lovejoy Magdalena Szewczyk Fengling Li Parnian Lak Matthew Cuellar Philip A. Cole Jordan L. Meier Tim Thomas Jonathan B. Baell Peter J. Brown Michael A. Walters Paul A. Clemons Stuart L. Schreiber Bridget K. Wagner |
| author_facet | Jayme L. Dahlin Bruce K. Hua Beth E. Zucconi Shawn D. Nelson Shantanu Singh Anne E. Carpenter Jonathan H. Shrimp Evelyne Lima-Fernandes Mathias J. Wawer Lawrence P. W. Chung Ayushi Agrawal Mary O’Reilly Dalia Barsyte-Lovejoy Magdalena Szewczyk Fengling Li Parnian Lak Matthew Cuellar Philip A. Cole Jordan L. Meier Tim Thomas Jonathan B. Baell Peter J. Brown Michael A. Walters Paul A. Clemons Stuart L. Schreiber Bridget K. Wagner |
| author_sort | Jayme L. Dahlin |
| collection | DOAJ |
| description | Cellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with compound-dependent cellular injury and nuisance activity. |
| first_indexed | 2024-04-09T22:47:12Z |
| format | Article |
| id | doaj.art-a0652f03d5554808827f7867140b6ae5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:47:12Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a0652f03d5554808827f7867140b6ae52023-03-22T11:48:01ZengNature PortfolioNature Communications2041-17232023-03-0114111610.1038/s41467-023-36829-xReference compounds for characterizing cellular injury in high-content cellular morphology assaysJayme L. Dahlin0Bruce K. Hua1Beth E. Zucconi2Shawn D. Nelson3Shantanu Singh4Anne E. Carpenter5Jonathan H. Shrimp6Evelyne Lima-Fernandes7Mathias J. Wawer8Lawrence P. W. Chung9Ayushi Agrawal10Mary O’Reilly11Dalia Barsyte-Lovejoy12Magdalena Szewczyk13Fengling Li14Parnian Lak15Matthew Cuellar16Philip A. Cole17Jordan L. Meier18Tim Thomas19Jonathan B. Baell20Peter J. Brown21Michael A. Walters22Paul A. Clemons23Stuart L. Schreiber24Bridget K. Wagner25National Center for Advancing Translational Sciences, National Institutes of HealthChemical Biology and Therapeutics Science Program, Broad InstituteDivision of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women’s HospitalStanley Center, Broad InstituteImaging Platform, Broad InstituteImaging Platform, Broad InstituteChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of HealthStructural Genomics Consortium, University of TorontoChemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstitutePattern, Broad InstituteStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoStructural Genomics Consortium, University of TorontoDepartment of Pharmaceutical Chemistry and Quantitative Biology Institute, University of California San FranciscoInstitute for Therapeutics Discovery and Development, University of MinnesotaDivision of Genetics, Departments of Medicine and Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Brigham and Women’s HospitalChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of HealthDepartment of Medical Biology, University of MelbourneMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash UniversityStructural Genomics Consortium, University of TorontoInstitute for Therapeutics Discovery and Development, University of MinnesotaChemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstituteCellular nuisance compounds are a burden in chemical biology and drug screening. Here the authors profile prototypical cytotoxic and nuisance compounds using the cell painting assay to systematically characterise cellular morphologies associated with compound-dependent cellular injury and nuisance activity.https://doi.org/10.1038/s41467-023-36829-x |
| spellingShingle | Jayme L. Dahlin Bruce K. Hua Beth E. Zucconi Shawn D. Nelson Shantanu Singh Anne E. Carpenter Jonathan H. Shrimp Evelyne Lima-Fernandes Mathias J. Wawer Lawrence P. W. Chung Ayushi Agrawal Mary O’Reilly Dalia Barsyte-Lovejoy Magdalena Szewczyk Fengling Li Parnian Lak Matthew Cuellar Philip A. Cole Jordan L. Meier Tim Thomas Jonathan B. Baell Peter J. Brown Michael A. Walters Paul A. Clemons Stuart L. Schreiber Bridget K. Wagner Reference compounds for characterizing cellular injury in high-content cellular morphology assays Nature Communications |
| title | Reference compounds for characterizing cellular injury in high-content cellular morphology assays |
| title_full | Reference compounds for characterizing cellular injury in high-content cellular morphology assays |
| title_fullStr | Reference compounds for characterizing cellular injury in high-content cellular morphology assays |
| title_full_unstemmed | Reference compounds for characterizing cellular injury in high-content cellular morphology assays |
| title_short | Reference compounds for characterizing cellular injury in high-content cellular morphology assays |
| title_sort | reference compounds for characterizing cellular injury in high content cellular morphology assays |
| url | https://doi.org/10.1038/s41467-023-36829-x |
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