Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA
Host innate and adaptive immune responses play a vital role in clearing infected viruses. Meanwhile, viruses also evolve a series of mechanisms to weaken the host immune responses and evade immune defense. Recently, N6-methyladenosine (m6A), the most prevalent mRNA modification, has been revealed to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.789605/full |
| _version_ | 1819239244743311360 |
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| author | Baoxin Zhao Baoxin Zhao Weijie Wang Weijie Wang Yan Zhao Yan Zhao Hongxiu Qiao Hongxiu Qiao Zhiyun Gao Zhiyun Gao Xia Chuai Xia Chuai |
| author_facet | Baoxin Zhao Baoxin Zhao Weijie Wang Weijie Wang Yan Zhao Yan Zhao Hongxiu Qiao Hongxiu Qiao Zhiyun Gao Zhiyun Gao Xia Chuai Xia Chuai |
| author_sort | Baoxin Zhao |
| collection | DOAJ |
| description | Host innate and adaptive immune responses play a vital role in clearing infected viruses. Meanwhile, viruses also evolve a series of mechanisms to weaken the host immune responses and evade immune defense. Recently, N6-methyladenosine (m6A), the most prevalent mRNA modification, has been revealed to regulate multiple steps of RNA metabolism, such as mRNA splicing, localization, stabilization, and translation, thus participating in many biological phenomena, including viral infection. In the process of virus–host interaction, the m6A modification that presents on the virus RNA impedes capture by the pattern recognition receptors, and the m6A modification appearing on the host immune-related molecules regulate interferon response, immune cell differentiation, inflammatory cytokine production, and other immune responses induced by viral infection. This review summarizes the research advances about the regulatory role of m6A modification in the innate and adaptive immune responses during viral infections. |
| first_indexed | 2024-12-23T13:49:03Z |
| format | Article |
| id | doaj.art-a06631c481e84b9eb62e2f933eb8ecce |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-23T13:49:03Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-a06631c481e84b9eb62e2f933eb8ecce2022-12-21T17:44:38ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-12-011210.3389/fmicb.2021.789605789605Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNABaoxin Zhao0Baoxin Zhao1Weijie Wang2Weijie Wang3Yan Zhao4Yan Zhao5Hongxiu Qiao6Hongxiu Qiao7Zhiyun Gao8Zhiyun Gao9Xia Chuai10Xia Chuai11Department of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaDepartment of Pathogen Biology, Hebei Medical University, Shijiazhuang, ChinaInstitute of Medical and Health Science, Hebei Medical University, Shijiazhuang, ChinaHost innate and adaptive immune responses play a vital role in clearing infected viruses. Meanwhile, viruses also evolve a series of mechanisms to weaken the host immune responses and evade immune defense. Recently, N6-methyladenosine (m6A), the most prevalent mRNA modification, has been revealed to regulate multiple steps of RNA metabolism, such as mRNA splicing, localization, stabilization, and translation, thus participating in many biological phenomena, including viral infection. In the process of virus–host interaction, the m6A modification that presents on the virus RNA impedes capture by the pattern recognition receptors, and the m6A modification appearing on the host immune-related molecules regulate interferon response, immune cell differentiation, inflammatory cytokine production, and other immune responses induced by viral infection. This review summarizes the research advances about the regulatory role of m6A modification in the innate and adaptive immune responses during viral infections.https://www.frontiersin.org/articles/10.3389/fmicb.2021.789605/fullN6-methyladenosine modificationviral infectionimmune recognitioninnate immunityadaptive immunity |
| spellingShingle | Baoxin Zhao Baoxin Zhao Weijie Wang Weijie Wang Yan Zhao Yan Zhao Hongxiu Qiao Hongxiu Qiao Zhiyun Gao Zhiyun Gao Xia Chuai Xia Chuai Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA Frontiers in Microbiology N6-methyladenosine modification viral infection immune recognition innate immunity adaptive immunity |
| title | Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA |
| title_full | Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA |
| title_fullStr | Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA |
| title_full_unstemmed | Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA |
| title_short | Regulation of Antiviral Immune Response by N6-Methyladenosine of mRNA |
| title_sort | regulation of antiviral immune response by n6 methyladenosine of mrna |
| topic | N6-methyladenosine modification viral infection immune recognition innate immunity adaptive immunity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.789605/full |
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