Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy?
Purpose: The purpose of the study was to investigate the relation between inflammatory markers used for allergic diseases and intrahepatic pregnancy cholestasis (ICP). Materials and Methods: In this retrospective case-control study, a total of 114 intrahepatic pregnancy cholestasis patients; 87 wit...
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| Format: | Article |
| Language: | English |
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Cukurova University
2020-12-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1424706 |
| _version_ | 1797911328162054144 |
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| author | Ayça Şolt Derya Kanza Gül |
| author_facet | Ayça Şolt Derya Kanza Gül |
| author_sort | Ayça Şolt |
| collection | DOAJ |
| description | Purpose: The purpose of the study was to investigate the relation between inflammatory markers used for allergic diseases and intrahepatic pregnancy cholestasis (ICP).
Materials and Methods: In this retrospective case-control study, a total of 114 intrahepatic pregnancy cholestasis patients; 87 with mild cholestasis (group 1) and 27 with severe cholestasis (group 2) and 292 healthy pregnant women in the control group (group 3) were included in the study. The basophil, eosinophil, eosinophil-basophil ratio (EBR), eosinophil-lymphocyte ratio (ELR) and basophil-lymphocyte ratio (BLR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) values used in this study.
Results: Significant differences were detected between groups in terms of ELR, NLR and PLR values. ELR, NLR, PLR values were significantly higher in the mild cholestasis group than in the control group. To predict the pregnancy cholestasis, receiver operating characteristic curve (ROC) analysis was made, which yielded 76.3% sensitivity and 56.1% specificity when ELR’s interrupt value was 0.2243, NLR interrupt value 11.27% when sensitivity was 70% and specificity 54,000 2%, and PLR cut-off value was 194.46 when sensitivity was 60% and specificity was 58%.
Conclusion: Serum inflammation markers and allergy markers may be diagnostic in intrahepatic pregnancy cholestasis; however, they are not decisive in determining the severity of the disease. |
| first_indexed | 2024-04-10T11:38:52Z |
| format | Article |
| id | doaj.art-a069ed4cd677499da613786151f13d3a |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T11:38:52Z |
| publishDate | 2020-12-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-a069ed4cd677499da613786151f13d3a2023-02-15T16:17:37ZengCukurova UniversityCukurova Medical Journal2602-30402020-12-014541742174910.17826/cumj.83406348Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy?Ayça Şolt0Derya Kanza Gül1KIRKLARELI UNIVERSITYISTANBUL MEDIPOL UNIVERSITYPurpose: The purpose of the study was to investigate the relation between inflammatory markers used for allergic diseases and intrahepatic pregnancy cholestasis (ICP). Materials and Methods: In this retrospective case-control study, a total of 114 intrahepatic pregnancy cholestasis patients; 87 with mild cholestasis (group 1) and 27 with severe cholestasis (group 2) and 292 healthy pregnant women in the control group (group 3) were included in the study. The basophil, eosinophil, eosinophil-basophil ratio (EBR), eosinophil-lymphocyte ratio (ELR) and basophil-lymphocyte ratio (BLR), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) values used in this study. Results: Significant differences were detected between groups in terms of ELR, NLR and PLR values. ELR, NLR, PLR values were significantly higher in the mild cholestasis group than in the control group. To predict the pregnancy cholestasis, receiver operating characteristic curve (ROC) analysis was made, which yielded 76.3% sensitivity and 56.1% specificity when ELR’s interrupt value was 0.2243, NLR interrupt value 11.27% when sensitivity was 70% and specificity 54,000 2%, and PLR cut-off value was 194.46 when sensitivity was 60% and specificity was 58%. Conclusion: Serum inflammation markers and allergy markers may be diagnostic in intrahepatic pregnancy cholestasis; however, they are not decisive in determining the severity of the disease.https://dergipark.org.tr/tr/download/article-file/1424706intrahepatic cholestasis pregnancyallergy markersi̇ntrahepatik gebelik kolestazıalerji belirteçleriinflamasyon belirteçleri |
| spellingShingle | Ayça Şolt Derya Kanza Gül Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? Cukurova Medical Journal intrahepatic cholestasis pregnancy allergy markers i̇ntrahepatik gebelik kolestazı alerji belirteçleri inflamasyon belirteçleri |
| title | Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? |
| title_full | Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? |
| title_fullStr | Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? |
| title_full_unstemmed | Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? |
| title_short | Can blood eosinophil to basophil ratio, eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy? |
| title_sort | can blood eosinophil to basophil ratio eosinophil to lymphocyte ratio and basophil to lymphocyte ratio predict the severity of intrahepatic cholestasis in pregnancy |
| topic | intrahepatic cholestasis pregnancy allergy markers i̇ntrahepatik gebelik kolestazı alerji belirteçleri inflamasyon belirteçleri |
| url | https://dergipark.org.tr/tr/download/article-file/1424706 |
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