Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers
Gastrointestinal cancers (GICs) are high-incidence malignant tumors that seriously threaten human health around the world. Their complexity and heterogeneity make the classic staging system insufficient to guide patient management. Recently, competing endogenous RNA (ceRNA) interactions that closely...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.921194/full |
| _version_ | 1828541534498193408 |
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| author | Xin Qi Xingqi Chen Yuanchun Zhao Jiajia Chen Beifang Niu Beifang Niu Bairong Shen |
| author_facet | Xin Qi Xingqi Chen Yuanchun Zhao Jiajia Chen Beifang Niu Beifang Niu Bairong Shen |
| author_sort | Xin Qi |
| collection | DOAJ |
| description | Gastrointestinal cancers (GICs) are high-incidence malignant tumors that seriously threaten human health around the world. Their complexity and heterogeneity make the classic staging system insufficient to guide patient management. Recently, competing endogenous RNA (ceRNA) interactions that closely link the function of protein-coding RNAs with that of non-coding RNAs, such as long non-coding RNA (lncRNA) and circular RNA (circRNA), has emerged as a novel molecular mechanism influencing miRNA-mediated gene regulation. Especially, ceRNA networks have proven to be powerful tools for deciphering cancer mechanisms and predicting therapeutic responses at the system level. Moreover, abnormal gene expression is one of the critical breaking events that disturb the stability of ceRNA network, highlighting the role of molecular biomarkers in optimizing cancer management and treatment. Therefore, developing prognostic signatures based on cancer-specific ceRNA network is of great significance for predicting clinical outcome or chemotherapy benefits of GIC patients. We herein introduce the current frontiers of ceRNA crosstalk in relation to their pathological implications and translational potentials in GICs, review the current researches on the prognostic signatures based on lncRNA or circRNA-mediated ceRNA networks in GICs, and highlight the translational implications of ceRNA signatures for GICs management. Furthermore, we summarize the computational approaches for establishing ceRNA network-based prognostic signatures, providing important clues for deciphering GIC biomarkers. |
| first_indexed | 2024-12-12T01:42:25Z |
| format | Article |
| id | doaj.art-a06a8a4d35df405ea18c9e43da974b7c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T01:42:25Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-a06a8a4d35df405ea18c9e43da974b7c2022-12-22T00:42:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.921194921194Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal CancersXin Qi0Xingqi Chen1Yuanchun Zhao2Jiajia Chen3Beifang Niu4Beifang Niu5Bairong Shen6School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, ChinaSchool of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, ChinaComputer Network Information Center, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, ChinaGastrointestinal cancers (GICs) are high-incidence malignant tumors that seriously threaten human health around the world. Their complexity and heterogeneity make the classic staging system insufficient to guide patient management. Recently, competing endogenous RNA (ceRNA) interactions that closely link the function of protein-coding RNAs with that of non-coding RNAs, such as long non-coding RNA (lncRNA) and circular RNA (circRNA), has emerged as a novel molecular mechanism influencing miRNA-mediated gene regulation. Especially, ceRNA networks have proven to be powerful tools for deciphering cancer mechanisms and predicting therapeutic responses at the system level. Moreover, abnormal gene expression is one of the critical breaking events that disturb the stability of ceRNA network, highlighting the role of molecular biomarkers in optimizing cancer management and treatment. Therefore, developing prognostic signatures based on cancer-specific ceRNA network is of great significance for predicting clinical outcome or chemotherapy benefits of GIC patients. We herein introduce the current frontiers of ceRNA crosstalk in relation to their pathological implications and translational potentials in GICs, review the current researches on the prognostic signatures based on lncRNA or circRNA-mediated ceRNA networks in GICs, and highlight the translational implications of ceRNA signatures for GICs management. Furthermore, we summarize the computational approaches for establishing ceRNA network-based prognostic signatures, providing important clues for deciphering GIC biomarkers.https://www.frontiersin.org/articles/10.3389/fonc.2022.921194/fullceRNA networkprognostic signaturegastrointestinal cancertranslational implicationlncRNAcircRNA |
| spellingShingle | Xin Qi Xingqi Chen Yuanchun Zhao Jiajia Chen Beifang Niu Beifang Niu Bairong Shen Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers Frontiers in Oncology ceRNA network prognostic signature gastrointestinal cancer translational implication lncRNA circRNA |
| title | Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers |
| title_full | Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers |
| title_fullStr | Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers |
| title_full_unstemmed | Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers |
| title_short | Prognostic Roles of ceRNA Network-Based Signatures in Gastrointestinal Cancers |
| title_sort | prognostic roles of cerna network based signatures in gastrointestinal cancers |
| topic | ceRNA network prognostic signature gastrointestinal cancer translational implication lncRNA circRNA |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.921194/full |
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