Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Copy number variation and expression of exportin-4 associates with severity of fibrosis in metabolic associated fatty liver disease

Background: Liver fibrosis risk is a heritable trait, the outcome of which is the net deposition of extracellular matrix by hepatic stellate cell-derived myofibroblasts. Whereas nucleotide sequence variations have been extensively studied in liver fibrosis, the role of copy number variations (CNV) i...

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Main Authors: Mayada Metwally, Ali Bayoumi, Anis Khan, Leon A. Adams, Rocio Aller, Carmelo García-Monzón, María Teresa Arias-Loste, Elisabetta Bugianesi, Luca Miele, Alisi Anna, Olivier Latchoumanin, Shuanglin Han, Shafi Alenizi, Rasha EL Sharkawy, Afaf Elattar, Rocio Gallego-Durán, Janett Fischer, Thomas Berg, Christopher Liddle, Manuel Romero-Gomez, Jacob George, Mohammed Eslam
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:EBioMedicine
Subjects:
MAFLD
XPO4
Fibrosis
TGFβ
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421003145

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