Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis
<h4>Introduction</h4> A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. The...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012355/?tool=EBI |
| _version_ | 1811304182611705856 |
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| author | Hae Do Jung Kang Su Cho Young Joon Moon Doo Yong Chung Dong Hyuk Kang Joo Yong Lee |
| author_facet | Hae Do Jung Kang Su Cho Young Joon Moon Doo Yong Chung Dong Hyuk Kang Joo Yong Lee |
| author_sort | Hae Do Jung |
| collection | DOAJ |
| description | <h4>Introduction</h4> A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. Therefore, we performed a systematic review and meta-analysis comparing single- and extended-dose antibiotic prophylaxis for PCNL. <h4>Materials and methods</h4> Relevant studies that compared single- and extended-dose antibiotic prophylactic therapies were identified. Articles were selected from PubMed, EMBASE, KoreaMed, and Google Scholar up to September 2021. Fever and systemic inflammatory response syndrome (SIRS) were compared by meta-analysis. A subgroup analysis was performed according to the degree of risk to the patient. <h4>Results</h4> A total of 10 articles were included in this study. There were no significant differences between single dose and extended dose in the rate of fever [p = 0.93, OR = 0.96, 95% confidence interval (CI) 0.44–2.13, I2 = 64%]. Extended dose showed lower rate of SIRS compared to single dose (p = 0.0005, OR = 1.81, 95% CI 1.30–2.53, I2 = 53%); in the subgroup analysis, extended dose also showed lower rates of SIRS compared to single dose in high-risk patients (p <0.0001, OR = 3.53, 95% CI 1.91–6.54, I2 = 36%). <h4>Conclusions</h4> The results of our meta-analysis showed that single-dose antibiotic prophylaxis can be effective for PCNL, but extended-dose antibiotics can be required in high-risk patients to reduce post-PCNL infection-related complications. |
| first_indexed | 2024-04-13T08:02:36Z |
| format | Article |
| id | doaj.art-a06b73336c7349418e0e41f54ae16b80 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T08:02:36Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-a06b73336c7349418e0e41f54ae16b802022-12-22T02:55:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01174Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysisHae Do JungKang Su ChoYoung Joon MoonDoo Yong ChungDong Hyuk KangJoo Yong Lee<h4>Introduction</h4> A single dose of preventive antibiotics is known to be sufficient to reduce the rate of infection-related complications in percutaneous nephrolithotomy (PCNL). However, some studies reported that the extended dose showed lower complications for high-risk groups. Therefore, we performed a systematic review and meta-analysis comparing single- and extended-dose antibiotic prophylaxis for PCNL. <h4>Materials and methods</h4> Relevant studies that compared single- and extended-dose antibiotic prophylactic therapies were identified. Articles were selected from PubMed, EMBASE, KoreaMed, and Google Scholar up to September 2021. Fever and systemic inflammatory response syndrome (SIRS) were compared by meta-analysis. A subgroup analysis was performed according to the degree of risk to the patient. <h4>Results</h4> A total of 10 articles were included in this study. There were no significant differences between single dose and extended dose in the rate of fever [p = 0.93, OR = 0.96, 95% confidence interval (CI) 0.44–2.13, I2 = 64%]. Extended dose showed lower rate of SIRS compared to single dose (p = 0.0005, OR = 1.81, 95% CI 1.30–2.53, I2 = 53%); in the subgroup analysis, extended dose also showed lower rates of SIRS compared to single dose in high-risk patients (p <0.0001, OR = 3.53, 95% CI 1.91–6.54, I2 = 36%). <h4>Conclusions</h4> The results of our meta-analysis showed that single-dose antibiotic prophylaxis can be effective for PCNL, but extended-dose antibiotics can be required in high-risk patients to reduce post-PCNL infection-related complications.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012355/?tool=EBI |
| spellingShingle | Hae Do Jung Kang Su Cho Young Joon Moon Doo Yong Chung Dong Hyuk Kang Joo Yong Lee Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis PLoS ONE |
| title | Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis |
| title_full | Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis |
| title_fullStr | Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis |
| title_full_unstemmed | Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis |
| title_short | Antibiotic prophylaxis for percutaneous nephrolithotomy: An updated systematic review and meta-analysis |
| title_sort | antibiotic prophylaxis for percutaneous nephrolithotomy an updated systematic review and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9012355/?tool=EBI |
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