Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment
The liposome is the first nanomedicine transformed into the market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs. Numerous investigations about liposome uses...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087622001040 |
| _version_ | 1798006114187476992 |
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| author | Yonglong He Wanting Zhang Qingqing Xiao Lifang Fan Dechun Huang Wei Chen Wei He |
| author_facet | Yonglong He Wanting Zhang Qingqing Xiao Lifang Fan Dechun Huang Wei Chen Wei He |
| author_sort | Yonglong He |
| collection | DOAJ |
| description | The liposome is the first nanomedicine transformed into the market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs. Numerous investigations about liposome uses were conducted in different treatment fields, including anti-tumor, anti-fungal, anti-bacterial, and clinical analgesia, owing to liposome's ability to reduce drug cytotoxicity and improve the therapeutic efficacy and combinatorial delivery. In particular, two liposomal vaccines were approved in 2021 to combat COVID-19. Herein, the clinically used liposomes are reviewed by introducing various liposomal preparations in detail that are currently proceeding in the clinic or on the market. Finally, we discuss the challenges of developing liposomes and cutting-edge liposomal delivery for biological drugs and combination therapy. |
| first_indexed | 2024-04-11T12:50:00Z |
| format | Article |
| id | doaj.art-a06cdbbd38f34c84824b6497207ccbde |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-04-11T12:50:00Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-a06cdbbd38f34c84824b6497207ccbde2022-12-22T04:23:14ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762022-11-01176817837Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatmentYonglong He0Wanting Zhang1Qingqing Xiao2Lifang Fan3Dechun Huang4Wei Chen5Wei He6School of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaJiangsu Aosaikang Pharmaceutical Co., Ltd., Nanjing 211112, ChinaSchool of Engineering, China Pharmaceutical University, Nanjing 210009, ChinaSchool of Engineering, China Pharmaceutical University, Nanjing 210009, China; Corresponding authors.Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China; School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Corresponding authors.The liposome is the first nanomedicine transformed into the market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs. Numerous investigations about liposome uses were conducted in different treatment fields, including anti-tumor, anti-fungal, anti-bacterial, and clinical analgesia, owing to liposome's ability to reduce drug cytotoxicity and improve the therapeutic efficacy and combinatorial delivery. In particular, two liposomal vaccines were approved in 2021 to combat COVID-19. Herein, the clinically used liposomes are reviewed by introducing various liposomal preparations in detail that are currently proceeding in the clinic or on the market. Finally, we discuss the challenges of developing liposomes and cutting-edge liposomal delivery for biological drugs and combination therapy.http://www.sciencedirect.com/science/article/pii/S1818087622001040LiposomesDrug deliveryClinical applicationCOVID-19 pandemic |
| spellingShingle | Yonglong He Wanting Zhang Qingqing Xiao Lifang Fan Dechun Huang Wei Chen Wei He Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment Asian Journal of Pharmaceutical Sciences Liposomes Drug delivery Clinical application COVID-19 pandemic |
| title | Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment |
| title_full | Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment |
| title_fullStr | Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment |
| title_full_unstemmed | Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment |
| title_short | Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment |
| title_sort | liposomes and liposome like nanoparticles from anti fungal infection to the covid 19 pandemic treatment |
| topic | Liposomes Drug delivery Clinical application COVID-19 pandemic |
| url | http://www.sciencedirect.com/science/article/pii/S1818087622001040 |
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