Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix
Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections. Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation c...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/13/3136 |
| _version_ | 1797480695291969536 |
|---|---|
| author | Karen Bräutigam Stefanie Meier Sabina Meneder Louisa Proppe Katharina Stroschein Stephan Polack Frank Köster Achim Rody Sascha Baum |
| author_facet | Karen Bräutigam Stefanie Meier Sabina Meneder Louisa Proppe Katharina Stroschein Stephan Polack Frank Köster Achim Rody Sascha Baum |
| author_sort | Karen Bräutigam |
| collection | DOAJ |
| description | Background: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections. Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. HPV genotyping was performed using the EUROArray HPV test. Results: Positivity of HR HPV was found in 60.4–64.3% of anogenital and 14.6% of oral samples. HPV 16 showed the highest incidence in all investigated areas. In cervical and vaginal samples HPV 31 was detected second most, while in vulvar, anal, and oral samples HPV 53 was the second most common subtype. HPV 18 was found lower in all areas, while HPV 51, HPV 52, and HPV 73 were detected higher than expected from published data. A good concordance between cervical, vaginal and vulvar samples was examined for most of the HPV. HR HPV infection was higher in cervical cancer (CC; 91.7%) and high-grade intraepithelial squamous lesions (HSIL; 93.9%) compared to low-grade SIL (LSIL; 69.6%) and normal samples (44.8%). Conclusion: In addition to the well described HPV subtypes, we found others with high incidences in the investigated areas which may be evident for HSIL and CC of those areas. |
| first_indexed | 2024-03-09T22:03:47Z |
| format | Article |
| id | doaj.art-a06d90045f8b4277a7e77052fdffb2dd |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:03:47Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-a06d90045f8b4277a7e77052fdffb2dd2023-11-23T19:45:01ZengMDPI AGCancers2072-66942022-06-011413313610.3390/cancers14133136Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the CervixKaren Bräutigam0Stefanie Meier1Sabina Meneder2Louisa Proppe3Katharina Stroschein4Stephan Polack5Frank Köster6Achim Rody7Sascha Baum8Department of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyDepartment of Gynecology and Obstetrics, Campus Lübeck, University Medical Center Schleswig-Holstein, 23538 Lübeck, GermanyGynäkologie des MVZ Westpfalz, 67655 Kaiserslautern, GermanyBackground: Cancers and intraepithelial lesions of different anogenital areas as well as oral cancer are associated with human papilloma virus (HPV) infections. Methods: In this study cervical, vaginal, vulvar, anal, and oral samples were taken from 509 patients visiting our dysplasia consultation clinic. HPV genotyping was performed using the EUROArray HPV test. Results: Positivity of HR HPV was found in 60.4–64.3% of anogenital and 14.6% of oral samples. HPV 16 showed the highest incidence in all investigated areas. In cervical and vaginal samples HPV 31 was detected second most, while in vulvar, anal, and oral samples HPV 53 was the second most common subtype. HPV 18 was found lower in all areas, while HPV 51, HPV 52, and HPV 73 were detected higher than expected from published data. A good concordance between cervical, vaginal and vulvar samples was examined for most of the HPV. HR HPV infection was higher in cervical cancer (CC; 91.7%) and high-grade intraepithelial squamous lesions (HSIL; 93.9%) compared to low-grade SIL (LSIL; 69.6%) and normal samples (44.8%). Conclusion: In addition to the well described HPV subtypes, we found others with high incidences in the investigated areas which may be evident for HSIL and CC of those areas.https://www.mdpi.com/2072-6694/14/13/3136HPV subtype distributionanogenital and oralcervical cancerintraepithelial lesionhigh-risk HPV |
| spellingShingle | Karen Bräutigam Stefanie Meier Sabina Meneder Louisa Proppe Katharina Stroschein Stephan Polack Frank Köster Achim Rody Sascha Baum Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix Cancers HPV subtype distribution anogenital and oral cervical cancer intraepithelial lesion high-risk HPV |
| title | Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix |
| title_full | Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix |
| title_fullStr | Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix |
| title_full_unstemmed | Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix |
| title_short | Distribution of HPV Subtypes in Diverse Anogenital and Oral Samples from Women and Correlation of Infections with Neoplasia of the Cervix |
| title_sort | distribution of hpv subtypes in diverse anogenital and oral samples from women and correlation of infections with neoplasia of the cervix |
| topic | HPV subtype distribution anogenital and oral cervical cancer intraepithelial lesion high-risk HPV |
| url | https://www.mdpi.com/2072-6694/14/13/3136 |
| work_keys_str_mv | AT karenbrautigam distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT stefaniemeier distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT sabinameneder distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT louisaproppe distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT katharinastroschein distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT stephanpolack distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT frankkoster distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT achimrody distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix AT saschabaum distributionofhpvsubtypesindiverseanogenitalandoralsamplesfromwomenandcorrelationofinfectionswithneoplasiaofthecervix |