The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread
A gB/MF59 vaccine candidate for human cytomegalovirus (HCMV) provided partial protection in organ transplant patients. Here, the authors identify antibody responses in trial participants that target virally infected cells to control cell-to-cell spread of HCMV, providing a potential mechanism for th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36683-x |
| _version_ | 1797864185338527744 |
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| author | A. C. Gomes I. A. Baraniak A. Lankina Z. Moulder P. Holenya C. Atkinson G. Tang T. Mahungu F. Kern P. D. Griffiths M. B. Reeves |
| author_facet | A. C. Gomes I. A. Baraniak A. Lankina Z. Moulder P. Holenya C. Atkinson G. Tang T. Mahungu F. Kern P. D. Griffiths M. B. Reeves |
| author_sort | A. C. Gomes |
| collection | DOAJ |
| description | A gB/MF59 vaccine candidate for human cytomegalovirus (HCMV) provided partial protection in organ transplant patients. Here, the authors identify antibody responses in trial participants that target virally infected cells to control cell-to-cell spread of HCMV, providing a potential mechanism for the observed protection. |
| first_indexed | 2024-04-09T22:48:27Z |
| format | Article |
| id | doaj.art-a06f669d9dfd48409d521db00dd25eba |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:48:27Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a06f669d9dfd48409d521db00dd25eba2023-03-22T11:45:23ZengNature PortfolioNature Communications2041-17232023-02-0114111210.1038/s41467-023-36683-xThe cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spreadA. C. Gomes0I. A. Baraniak1A. Lankina2Z. Moulder3P. Holenya4C. Atkinson5G. Tang6T. Mahungu7F. Kern8P. D. Griffiths9M. B. Reeves10Institute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLJPT Peptide Technologies GmbHInstitute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLJPT Peptide Technologies GmbHInstitute of Immunity & Transplantation, UCLInstitute of Immunity & Transplantation, UCLA gB/MF59 vaccine candidate for human cytomegalovirus (HCMV) provided partial protection in organ transplant patients. Here, the authors identify antibody responses in trial participants that target virally infected cells to control cell-to-cell spread of HCMV, providing a potential mechanism for the observed protection.https://doi.org/10.1038/s41467-023-36683-x |
| spellingShingle | A. C. Gomes I. A. Baraniak A. Lankina Z. Moulder P. Holenya C. Atkinson G. Tang T. Mahungu F. Kern P. D. Griffiths M. B. Reeves The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread Nature Communications |
| title | The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread |
| title_full | The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread |
| title_fullStr | The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread |
| title_full_unstemmed | The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread |
| title_short | The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread |
| title_sort | cytomegalovirus gb mf59 vaccine candidate induces antibodies against an antigenic domain controlling cell to cell spread |
| url | https://doi.org/10.1038/s41467-023-36683-x |
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