Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years
Abstract Background An observer-reported outcome (ObsRO) measure assessing both symptom control and health-related quality of life (HRQoL) in children with asthma younger than 6 years is lacking. The objective of this study was to evaluate the content validity of the Pediatric Asthma Questionnaire (...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-05-01
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| Series: | Journal of Patient-Reported Outcomes |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41687-022-00461-y |
| _version_ | 1817989698946072576 |
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| author | Yi Zhang Jennifer L. Clegg Shannon Keith Shehan McFadden Tara Symonds Rajesh Kumar Asif H. Khan Siddhesh Kamat Jingdong Chao |
| author_facet | Yi Zhang Jennifer L. Clegg Shannon Keith Shehan McFadden Tara Symonds Rajesh Kumar Asif H. Khan Siddhesh Kamat Jingdong Chao |
| author_sort | Yi Zhang |
| collection | DOAJ |
| description | Abstract Background An observer-reported outcome (ObsRO) measure assessing both symptom control and health-related quality of life (HRQoL) in children with asthma younger than 6 years is lacking. The objective of this study was to evaluate the content validity of the Pediatric Asthma Questionnaire (PAQ), a newly developed 6-item ObsRO measure for caregivers of children aged 2–5 years diagnosed with asthma. Results In-depth, qualitative interviews were conducted with 15 parents or caregivers. The first part of the interview was an open-ended discussion whereby participants were asked to describe their observations of their child’s asthma symptoms and HRQoL impacts followed by a cognitive debriefing of a draft version of the PAQ. The most frequently reported symptoms were coughing (n = 15, 100%), wheezing (n = 14, 93%), and trouble breathing (n = 10, 67%). Overall, participants found the PAQ easy to complete and relevant to their child’s experience with asthma, with most reporting the instructions, response scales, and recall period for the items to be appropriate. The majority of participants (93%) believed they could accurately report on the items included in the PAQ based on their observations of their child’s asthma symptoms and impacts, or reliably get the information from the child’s teacher, school, or caregiver when their child was not in their presence. One item was modified based on feedback about the phrase “oral steroids” to clarify modes of administration. A few other minor changes were incorporated into the PAQ following suggestions from participants, including replacing the phrase “how often” with “how many days” in one of the items to improve clarity and overall consistency with the response options. Conclusion Qualitative data support the content validity of the PAQ as a fit-for-purpose and well-understood 6-item observer-reported outcome measure to evaluate both symptoms and asthma-specific HRQoL impacts experienced by pediatric asthma patients aged 2–5 years for use in clinical and real-world studies. |
| first_indexed | 2024-04-14T00:49:55Z |
| format | Article |
| id | doaj.art-a06f8483a33245d3bf334dcdf5566abe |
| institution | Directory Open Access Journal |
| issn | 2509-8020 |
| language | English |
| last_indexed | 2024-04-14T00:49:55Z |
| publishDate | 2022-05-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Patient-Reported Outcomes |
| spelling | doaj.art-a06f8483a33245d3bf334dcdf5566abe2022-12-22T02:21:50ZengSpringerOpenJournal of Patient-Reported Outcomes2509-80202022-05-016111110.1186/s41687-022-00461-yContent validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 yearsYi Zhang0Jennifer L. Clegg1Shannon Keith2Shehan McFadden3Tara Symonds4Rajesh Kumar5Asif H. Khan6Siddhesh Kamat7Jingdong Chao8Regeneron PharmaceuticalsClinical Outcomes Assessment, Clinical Outcomes SolutionsClinical Outcomes Assessment, Clinical Outcomes SolutionsClinical Outcomes Assessment, Clinical Outcomes SolutionsClinical Outcomes SolutionsLurie Children’s HospitalSanofiRegeneron PharmaceuticalsRegeneron PharmaceuticalsAbstract Background An observer-reported outcome (ObsRO) measure assessing both symptom control and health-related quality of life (HRQoL) in children with asthma younger than 6 years is lacking. The objective of this study was to evaluate the content validity of the Pediatric Asthma Questionnaire (PAQ), a newly developed 6-item ObsRO measure for caregivers of children aged 2–5 years diagnosed with asthma. Results In-depth, qualitative interviews were conducted with 15 parents or caregivers. The first part of the interview was an open-ended discussion whereby participants were asked to describe their observations of their child’s asthma symptoms and HRQoL impacts followed by a cognitive debriefing of a draft version of the PAQ. The most frequently reported symptoms were coughing (n = 15, 100%), wheezing (n = 14, 93%), and trouble breathing (n = 10, 67%). Overall, participants found the PAQ easy to complete and relevant to their child’s experience with asthma, with most reporting the instructions, response scales, and recall period for the items to be appropriate. The majority of participants (93%) believed they could accurately report on the items included in the PAQ based on their observations of their child’s asthma symptoms and impacts, or reliably get the information from the child’s teacher, school, or caregiver when their child was not in their presence. One item was modified based on feedback about the phrase “oral steroids” to clarify modes of administration. A few other minor changes were incorporated into the PAQ following suggestions from participants, including replacing the phrase “how often” with “how many days” in one of the items to improve clarity and overall consistency with the response options. Conclusion Qualitative data support the content validity of the PAQ as a fit-for-purpose and well-understood 6-item observer-reported outcome measure to evaluate both symptoms and asthma-specific HRQoL impacts experienced by pediatric asthma patients aged 2–5 years for use in clinical and real-world studies.https://doi.org/10.1186/s41687-022-00461-yPediatric Asthma QuestionnairePAQContent validityHealth-related quality of lifeHRQoLPatient-reported outcome |
| spellingShingle | Yi Zhang Jennifer L. Clegg Shannon Keith Shehan McFadden Tara Symonds Rajesh Kumar Asif H. Khan Siddhesh Kamat Jingdong Chao Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years Journal of Patient-Reported Outcomes Pediatric Asthma Questionnaire PAQ Content validity Health-related quality of life HRQoL Patient-reported outcome |
| title | Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years |
| title_full | Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years |
| title_fullStr | Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years |
| title_full_unstemmed | Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years |
| title_short | Content validity of a newly developed observer-reported measure for pediatric asthma in children aged 2–5 years |
| title_sort | content validity of a newly developed observer reported measure for pediatric asthma in children aged 2 5 years |
| topic | Pediatric Asthma Questionnaire PAQ Content validity Health-related quality of life HRQoL Patient-reported outcome |
| url | https://doi.org/10.1186/s41687-022-00461-y |
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