CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients
Aim. To study prognostic value of plasma soluble CD40 ligand (sCD40L) level in patients with various coronary heart disease (CHD) forms.Material and methods. In total, 65 CHD patients were examined, including 26 with stable effort angina (SEA), functional class (FC) I6III; 23 – with unstable angina...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2008-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1058 |
| _version_ | 1797882754782724096 |
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| author | O. P. Shevchenko O. F. Prirodova A. O. Shevchenko O. V. Orlova A. N. Britov |
| author_facet | O. P. Shevchenko O. F. Prirodova A. O. Shevchenko O. V. Orlova A. N. Britov |
| author_sort | O. P. Shevchenko |
| collection | DOAJ |
| description | Aim. To study prognostic value of plasma soluble CD40 ligand (sCD40L) level in patients with various coronary heart disease (CHD) forms.Material and methods. In total, 65 CHD patients were examined, including 26 with stable effort angina (SEA), functional class (FC) I6III; 23 – with unstable angina (UA), Stage II6IIIB; 15 – with myocardial infarction (MI). Levels of sCD40L, highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), and fibrinogen were measured. Follow-up period lasted for 24 months. End-points included death from any cause, non6fatal MI, ischemic stroke, myocardial revascularization, hospitalization due to SEA progression or UA development.Results. In SEA, UA and MI patients, sCD40L levels were similar. Type 2 diabetes mellitus (DM-2) patients had significantly higher sCD40L levels, comparing to other CHD participants. Cardiovascular event (CVE)-free survival analysis demonstrated that in CHD patients with low sCD40L levels, survival was significantly better than in participants with its higher levels, even after DM-2 patients' exclusion.Conclusion. In CHD patients, initially increased sCD40L level is an independent predictor of adverse CVE during two-year follow-up. |
| first_indexed | 2024-04-10T03:39:42Z |
| format | Article |
| id | doaj.art-a070dfb2532b466aafab1b345685f5e8 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:39:42Z |
| publishDate | 2008-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-a070dfb2532b466aafab1b345685f5e82023-03-13T07:23:14Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252008-02-01713945771CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patientsO. P. Shevchenko0O. F. Prirodova1A. O. Shevchenko2O. V. Orlova3A. N. Britov4Российский государственный медицинский университет на базе Клинической больницы Управления делами Президента РФРоссийский государственный медицинский университет на базе Клинической больницы Управления делами Президента РФРоссийский государственный медицинский университет на базе Клинической больницы Управления делами Президента РФНИИ трансплантологии и искусственных органов, г. МоскваРоссийский государственный медицинский университет на базе Клинической больницы Управления делами Президента РФAim. To study prognostic value of plasma soluble CD40 ligand (sCD40L) level in patients with various coronary heart disease (CHD) forms.Material and methods. In total, 65 CHD patients were examined, including 26 with stable effort angina (SEA), functional class (FC) I6III; 23 – with unstable angina (UA), Stage II6IIIB; 15 – with myocardial infarction (MI). Levels of sCD40L, highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), and fibrinogen were measured. Follow-up period lasted for 24 months. End-points included death from any cause, non6fatal MI, ischemic stroke, myocardial revascularization, hospitalization due to SEA progression or UA development.Results. In SEA, UA and MI patients, sCD40L levels were similar. Type 2 diabetes mellitus (DM-2) patients had significantly higher sCD40L levels, comparing to other CHD participants. Cardiovascular event (CVE)-free survival analysis demonstrated that in CHD patients with low sCD40L levels, survival was significantly better than in participants with its higher levels, even after DM-2 patients' exclusion.Conclusion. In CHD patients, initially increased sCD40L level is an independent predictor of adverse CVE during two-year follow-up.https://cardiovascular.elpub.ru/jour/article/view/1058растворимая форма лиганда сd40ишемическая болезнь сердцавыживаемостьнежелательные сердечно-сосудистые события |
| spellingShingle | O. P. Shevchenko O. F. Prirodova A. O. Shevchenko O. V. Orlova A. N. Britov CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients Кардиоваскулярная терапия и профилактика растворимая форма лиганда сd40 ишемическая болезнь сердца выживаемость нежелательные сердечно-сосудистые события |
| title | CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| title_full | CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| title_fullStr | CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| title_full_unstemmed | CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| title_short | CD40 ligand level – vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| title_sort | cd40 ligand level vascular inflammation activity and long6term prognosis in coronary heart disease patients |
| topic | растворимая форма лиганда сd40 ишемическая болезнь сердца выживаемость нежелательные сердечно-сосудистые события |
| url | https://cardiovascular.elpub.ru/jour/article/view/1058 |
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