Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering
Hui Feng,1 Yang Yue,1 Yan Zhang,1 Jingqi Liang,1 Liang Liu,1 Qiong Wang,1 Qian Feng,2 Hongmou Zhao1 1Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi, 710054, People’s Republic of China; 2Key Laboratory of Biorheological Science and Technology...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-02-01
|
| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/plant-derived-exosome-like-nanoparticles-emerging-nanosystems-for-enha-peer-reviewed-fulltext-article-IJN |
| _version_ | 1827355427990405120 |
|---|---|
| author | Feng H Yue Y Zhang Y Liang J Liu L Wang Q Feng Q Zhao H |
| author_facet | Feng H Yue Y Zhang Y Liang J Liu L Wang Q Feng Q Zhao H |
| author_sort | Feng H |
| collection | DOAJ |
| description | Hui Feng,1 Yang Yue,1 Yan Zhang,1 Jingqi Liang,1 Liang Liu,1 Qiong Wang,1 Qian Feng,2 Hongmou Zhao1 1Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi, 710054, People’s Republic of China; 2Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, People’s Republic of ChinaCorrespondence: Hongmou Zhao, Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi, 710054, People’s Republic of China, Email zhaohongmou@xiyi.edu.cn Qian Feng, Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, People’s Republic of China, Email qianfeng@cqu.edu.cnAbstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied in clinical disease management, especially for tissue regeneration. In this review, we comprehensively examine the properties, characteristics, and isolation techniques of plant ELNs. We also discuss their impact on the immune system, compatibility with the human body, and their role in tissue regeneration. To ensure the suitability of plant ELNs for tissue engineering, we explore various engineering and modification strategies. Additionally, we provide insights into the progress of commercialization and industrial perspectives on plant ELNs. This review aims to highlight the potential of plant ELNs in regenerative medicine by exploring the current research landscape and key findings.Keywords: plant, exosome-like nanoparticles, nanomedicine, tissue engineering, cartilage, wound, bone |
| first_indexed | 2024-03-08T04:11:48Z |
| format | Article |
| id | doaj.art-a0718a5a51534eaf8ee6e7f560487e76 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-08T04:11:48Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-a0718a5a51534eaf8ee6e7f560487e762024-02-08T18:28:25ZengDove Medical PressInternational Journal of Nanomedicine1178-20132024-02-01Volume 191189120490266Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue EngineeringFeng HYue YZhang YLiang JLiu LWang QFeng QZhao HHui Feng,1 Yang Yue,1 Yan Zhang,1 Jingqi Liang,1 Liang Liu,1 Qiong Wang,1 Qian Feng,2 Hongmou Zhao1 1Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi, 710054, People’s Republic of China; 2Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, People’s Republic of ChinaCorrespondence: Hongmou Zhao, Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi, 710054, People’s Republic of China, Email zhaohongmou@xiyi.edu.cn Qian Feng, Key Laboratory of Biorheological Science and Technology Ministry of Education College of Bioengineering, Chongqing University, Chongqing, 400044, People’s Republic of China, Email qianfeng@cqu.edu.cnAbstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in tissue engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied in clinical disease management, especially for tissue regeneration. In this review, we comprehensively examine the properties, characteristics, and isolation techniques of plant ELNs. We also discuss their impact on the immune system, compatibility with the human body, and their role in tissue regeneration. To ensure the suitability of plant ELNs for tissue engineering, we explore various engineering and modification strategies. Additionally, we provide insights into the progress of commercialization and industrial perspectives on plant ELNs. This review aims to highlight the potential of plant ELNs in regenerative medicine by exploring the current research landscape and key findings.Keywords: plant, exosome-like nanoparticles, nanomedicine, tissue engineering, cartilage, wound, bonehttps://www.dovepress.com/plant-derived-exosome-like-nanoparticles-emerging-nanosystems-for-enha-peer-reviewed-fulltext-article-IJNplantexosome-like nanoparticlesnanomedicinetissue engineeringcartilagewoundbone |
| spellingShingle | Feng H Yue Y Zhang Y Liang J Liu L Wang Q Feng Q Zhao H Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering International Journal of Nanomedicine plant exosome-like nanoparticles nanomedicine tissue engineering cartilage wound bone |
| title | Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering |
| title_full | Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering |
| title_fullStr | Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering |
| title_full_unstemmed | Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering |
| title_short | Plant-Derived Exosome-Like Nanoparticles: Emerging Nanosystems for Enhanced Tissue Engineering |
| title_sort | plant derived exosome like nanoparticles emerging nanosystems for enhanced tissue engineering |
| topic | plant exosome-like nanoparticles nanomedicine tissue engineering cartilage wound bone |
| url | https://www.dovepress.com/plant-derived-exosome-like-nanoparticles-emerging-nanosystems-for-enha-peer-reviewed-fulltext-article-IJN |
| work_keys_str_mv | AT fengh plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT yuey plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT zhangy plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT liangj plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT liul plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT wangq plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT fengq plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering AT zhaoh plantderivedexosomelikenanoparticlesemergingnanosystemsforenhancedtissueengineering |