Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases
Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, a high-affinity receptor...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1247422/full |
| _version_ | 1827818329307348992 |
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| author | Tadahiro Numakawa Ryutaro Kajihara Ryutaro Kajihara |
| author_facet | Tadahiro Numakawa Ryutaro Kajihara Ryutaro Kajihara |
| author_sort | Tadahiro Numakawa |
| collection | DOAJ |
| description | Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, a high-affinity receptor for BDNF, is involved in the physiological and pathological neuronal aspects via affecting cell viability, synaptic function, neurogenesis, and cognitive function. As expected, an alteration of the BDNF/TrkB system is suspected to be one of the molecular mechanisms underlying cognitive decline in cognitive diseases and mental disorders. Recent evidence has also highlighted a possible link between the alteration of TrkB signaling and chronic stress. Furthermore, it has been demonstrated that downregulation of the BDNF/TrkB system and chronic stress have a role in the pathogenesis of Alzheimer’s disease (AD) and mental disorders. In this review, we introduce current evidence showing a close relationship between the BDNF/TrkB system and the development of cognition impairment in stress-related disorders, and the possible contribution of the upregulation of the BDNF/TrkB system in a therapeutic approach against these brain diseases. |
| first_indexed | 2024-03-12T00:46:15Z |
| format | Article |
| id | doaj.art-a0738b61398c4edab43d0d55bd4c707d |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-12T00:46:15Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-a0738b61398c4edab43d0d55bd4c707d2023-09-14T15:43:50ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-09-011610.3389/fnmol.2023.12474221247422Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseasesTadahiro Numakawa0Ryutaro Kajihara1Ryutaro Kajihara2Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, JapanDepartment of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, JapanDepartment of Biomedical Laboratory Sciences, Faculty of Life Science, Kumamoto University, Kumamoto, JapanNeurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, a high-affinity receptor for BDNF, is involved in the physiological and pathological neuronal aspects via affecting cell viability, synaptic function, neurogenesis, and cognitive function. As expected, an alteration of the BDNF/TrkB system is suspected to be one of the molecular mechanisms underlying cognitive decline in cognitive diseases and mental disorders. Recent evidence has also highlighted a possible link between the alteration of TrkB signaling and chronic stress. Furthermore, it has been demonstrated that downregulation of the BDNF/TrkB system and chronic stress have a role in the pathogenesis of Alzheimer’s disease (AD) and mental disorders. In this review, we introduce current evidence showing a close relationship between the BDNF/TrkB system and the development of cognition impairment in stress-related disorders, and the possible contribution of the upregulation of the BDNF/TrkB system in a therapeutic approach against these brain diseases.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1247422/fullBDNFTrkBmajor depressive disorderAlzheimer’s diseaseglucocorticoid |
| spellingShingle | Tadahiro Numakawa Ryutaro Kajihara Ryutaro Kajihara Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases Frontiers in Molecular Neuroscience BDNF TrkB major depressive disorder Alzheimer’s disease glucocorticoid |
| title | Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases |
| title_full | Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases |
| title_fullStr | Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases |
| title_full_unstemmed | Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases |
| title_short | Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases |
| title_sort | involvement of brain derived neurotrophic factor signaling in the pathogenesis of stress related brain diseases |
| topic | BDNF TrkB major depressive disorder Alzheimer’s disease glucocorticoid |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1247422/full |
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