Biomarkers in acute myocardial infarction: current perspectives
Suleyman Aydin,1 Kader Ugur,2 Suna Aydin,3 İbrahim Sahin,1,4 Meltem Yardim1 1Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, Elazig 23119, Turkey; 2Department of Internal Medicine (Endocrinology and Metabolism Diseases),...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-01-01
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| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/biomarkers-in-acute-myocardial-infarction-current-perspectives-peer-reviewed-article-VHRM |
| _version_ | 1811270383196700672 |
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| author | Aydin S Ugur K Aydin S Sahin İ Yardim M |
| author_facet | Aydin S Ugur K Aydin S Sahin İ Yardim M |
| author_sort | Aydin S |
| collection | DOAJ |
| description | Suleyman Aydin,1 Kader Ugur,2 Suna Aydin,3 İbrahim Sahin,1,4 Meltem Yardim1 1Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, Elazig 23119, Turkey; 2Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig 23119, Turkey; 3Cardiovascular Surgery Department, Elazig Research and Education Hospital, Health Science University, Elazig 23119, Turkey; 4Department of Medical Biology, Medical School, Erzincan Binali Yildirim University, Erzincan 24100, Turkey Purpose: Acute myocardial infarction (AMI) is the most common cause of death in the world. Comprehensive risk assessment of patients presenting with chest pain and eliminating undesirable results should decrease morbidity and mortality rates, increase the quality of life of patients, and decrease health expenditure in many countries. In this study, the advantages and disadvantages of the enzymatic and nonenzymatic biomarkers used in the diagnosis of patients with AMI are given in historical sequence, and some candidate biomarkers – hFABP, GPBB, S100, PAPP-A, RP, TNF, IL6, IL18, CD40 ligand, MPO, MMP9, cell-adhesion molecules, oxidized LDL, glutathione, homocysteine, fibrinogen, and D-dimer procalcitonin – with a possible role in the diagnosis of AMI are discussed.Methods: The present study was carried out using meta-analyses, reviews of clinical trials, evidence-based medicine, and guidelines indexed in PubMed and Web of Science.Results: These numerous AMI biomarkers guide clinical applications (diagnostic methods, risk stratification, and treatment). Today, however, TnI remains the gold standard for the diagnosis of AMI. Details in the text will be given of many biomarkers for the diagnosis of AMI.Conclusion: We evaluated the advantages and disadvantages of routine enzymatic and nonenzymatic biomarkers and the literature evidence of other candidate biomarkers in the diagnosis of AMI, and discuss challenges and constraints that limit translational use from bench to bedside. Keywords: acute myocardial infarction, cardiac protein, cardiac peptide |
| first_indexed | 2024-04-12T21:59:49Z |
| format | Article |
| id | doaj.art-a0746537846c4c95a57f43e59c39c701 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-04-12T21:59:49Z |
| publishDate | 2019-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-a0746537846c4c95a57f43e59c39c7012022-12-22T03:15:09ZengDove Medical PressVascular Health and Risk Management1178-20482019-01-01Volume 1511043629Biomarkers in acute myocardial infarction: current perspectivesAydin SUgur KAydin SSahin İYardim MSuleyman Aydin,1 Kader Ugur,2 Suna Aydin,3 İbrahim Sahin,1,4 Meltem Yardim1 1Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, Elazig 23119, Turkey; 2Department of Internal Medicine (Endocrinology and Metabolism Diseases), School of Medicine, Firat University, Elazig 23119, Turkey; 3Cardiovascular Surgery Department, Elazig Research and Education Hospital, Health Science University, Elazig 23119, Turkey; 4Department of Medical Biology, Medical School, Erzincan Binali Yildirim University, Erzincan 24100, Turkey Purpose: Acute myocardial infarction (AMI) is the most common cause of death in the world. Comprehensive risk assessment of patients presenting with chest pain and eliminating undesirable results should decrease morbidity and mortality rates, increase the quality of life of patients, and decrease health expenditure in many countries. In this study, the advantages and disadvantages of the enzymatic and nonenzymatic biomarkers used in the diagnosis of patients with AMI are given in historical sequence, and some candidate biomarkers – hFABP, GPBB, S100, PAPP-A, RP, TNF, IL6, IL18, CD40 ligand, MPO, MMP9, cell-adhesion molecules, oxidized LDL, glutathione, homocysteine, fibrinogen, and D-dimer procalcitonin – with a possible role in the diagnosis of AMI are discussed.Methods: The present study was carried out using meta-analyses, reviews of clinical trials, evidence-based medicine, and guidelines indexed in PubMed and Web of Science.Results: These numerous AMI biomarkers guide clinical applications (diagnostic methods, risk stratification, and treatment). Today, however, TnI remains the gold standard for the diagnosis of AMI. Details in the text will be given of many biomarkers for the diagnosis of AMI.Conclusion: We evaluated the advantages and disadvantages of routine enzymatic and nonenzymatic biomarkers and the literature evidence of other candidate biomarkers in the diagnosis of AMI, and discuss challenges and constraints that limit translational use from bench to bedside. Keywords: acute myocardial infarction, cardiac protein, cardiac peptidehttps://www.dovepress.com/biomarkers-in-acute-myocardial-infarction-current-perspectives-peer-reviewed-article-VHRMAcute myocardial infarctioncardiac proteincardiac petetide |
| spellingShingle | Aydin S Ugur K Aydin S Sahin İ Yardim M Biomarkers in acute myocardial infarction: current perspectives Vascular Health and Risk Management Acute myocardial infarction cardiac protein cardiac petetide |
| title | Biomarkers in acute myocardial infarction: current perspectives |
| title_full | Biomarkers in acute myocardial infarction: current perspectives |
| title_fullStr | Biomarkers in acute myocardial infarction: current perspectives |
| title_full_unstemmed | Biomarkers in acute myocardial infarction: current perspectives |
| title_short | Biomarkers in acute myocardial infarction: current perspectives |
| title_sort | biomarkers in acute myocardial infarction current perspectives |
| topic | Acute myocardial infarction cardiac protein cardiac petetide |
| url | https://www.dovepress.com/biomarkers-in-acute-myocardial-infarction-current-perspectives-peer-reviewed-article-VHRM |
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