Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis
Abstract Background Dyslipidemia is responsible for more than half of the global ischemic heart disease (IHD) and more than 4 million deaths annually. Assessing the prevalence of dyslipidemia can be crucial in predicting the future disease development and possible intervention strategies. Therefore,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08910-9 |
| _version_ | 1827388757627633664 |
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| author | Ousman Mohammed Ermiyas Alemayehu Habtu Debash Melaku Ashagrie Belete Alemu Gedefie Mihret Tilahun Hussen Ebrahim Daniel Gebretsadik Weldehanna |
| author_facet | Ousman Mohammed Ermiyas Alemayehu Habtu Debash Melaku Ashagrie Belete Alemu Gedefie Mihret Tilahun Hussen Ebrahim Daniel Gebretsadik Weldehanna |
| author_sort | Ousman Mohammed |
| collection | DOAJ |
| description | Abstract Background Dyslipidemia is responsible for more than half of the global ischemic heart disease (IHD) and more than 4 million deaths annually. Assessing the prevalence of dyslipidemia can be crucial in predicting the future disease development and possible intervention strategies. Therefore, this systematic review and meta-analysis was aimed at assessing the pooled prevalence of dyslipidemia in HIV-infected patients. Methods Electronic databases such as EMBASE, Google Scholar, PubMed, Web of Science, ResearchGate, Cochrane Library, and Science Direct were searched for articles and grey literature. All relevant studies found until our search period of May 24, 2023 were included. The Newcastle–Ottawa Quality Assessment Scale was used to assess the quality of the included studies. The data were extracted in Microsoft Excel. The STATA version 14 software was used to conduct the meta-analysis. I2 and Cochran’s Q test were employed to assess the presence of heterogeneity between studies. Due to the presence of heterogeneity, a random effect model was used. The publication bias was assessed using the symmetry of the funnel plot and Egger's test statistics. Moreover, subgroup analysis, and sensitivity analysis were also done. Results A total of nine studies that reported the prevalence of dyslipidemia were included. The overall pooled prevalence of dyslipidemia among HIV-infected patients in Ethiopia was 67.32% (95% CI = 61.68%–72.96%). Furthermore, the overall pooled estimates of dyslipidemia among ART-taking and treatment-naïve HIV-infected patients were 69.74% (95% CI: 63.68–75.8, I2 = 87.2) and 61.46% (95% CI: 45.40–77.52, I2 = 90.3), respectively. Based on lipid profile fractionations, the pooled estimates for high total cholesterol (TC) were 39.08% (95% CI: 31.16–46.99), high triglycerides were 38.73% (95% CI: 28.58–48.88), high low density lipoprotein (LDL-c) was 28.40% (95% CI: 17.24–39.56), and low high density lipoprotein (HDL-c) was 39.42% (95% CI: 30.47–48.38). Conclusion More than two-thirds of HIV-infected patients experienced dyslipidemia. Therefore, it's critical to regularly evaluate lipid alterations in HIV-infected patients in order to prevent the onset of atherosclerosis and other cardiovascular problems. |
| first_indexed | 2024-03-08T16:23:34Z |
| format | Article |
| id | doaj.art-a075660536204ea8bd18025c51c9a7ab |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-08T16:23:34Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-a075660536204ea8bd18025c51c9a7ab2024-01-07T12:13:32ZengBMCBMC Infectious Diseases1471-23342024-01-0124111410.1186/s12879-023-08910-9Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysisOusman Mohammed0Ermiyas Alemayehu1Habtu Debash2Melaku Ashagrie Belete3Alemu Gedefie4Mihret Tilahun5Hussen Ebrahim6Daniel Gebretsadik Weldehanna7Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityDepartment of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo UniversityAbstract Background Dyslipidemia is responsible for more than half of the global ischemic heart disease (IHD) and more than 4 million deaths annually. Assessing the prevalence of dyslipidemia can be crucial in predicting the future disease development and possible intervention strategies. Therefore, this systematic review and meta-analysis was aimed at assessing the pooled prevalence of dyslipidemia in HIV-infected patients. Methods Electronic databases such as EMBASE, Google Scholar, PubMed, Web of Science, ResearchGate, Cochrane Library, and Science Direct were searched for articles and grey literature. All relevant studies found until our search period of May 24, 2023 were included. The Newcastle–Ottawa Quality Assessment Scale was used to assess the quality of the included studies. The data were extracted in Microsoft Excel. The STATA version 14 software was used to conduct the meta-analysis. I2 and Cochran’s Q test were employed to assess the presence of heterogeneity between studies. Due to the presence of heterogeneity, a random effect model was used. The publication bias was assessed using the symmetry of the funnel plot and Egger's test statistics. Moreover, subgroup analysis, and sensitivity analysis were also done. Results A total of nine studies that reported the prevalence of dyslipidemia were included. The overall pooled prevalence of dyslipidemia among HIV-infected patients in Ethiopia was 67.32% (95% CI = 61.68%–72.96%). Furthermore, the overall pooled estimates of dyslipidemia among ART-taking and treatment-naïve HIV-infected patients were 69.74% (95% CI: 63.68–75.8, I2 = 87.2) and 61.46% (95% CI: 45.40–77.52, I2 = 90.3), respectively. Based on lipid profile fractionations, the pooled estimates for high total cholesterol (TC) were 39.08% (95% CI: 31.16–46.99), high triglycerides were 38.73% (95% CI: 28.58–48.88), high low density lipoprotein (LDL-c) was 28.40% (95% CI: 17.24–39.56), and low high density lipoprotein (HDL-c) was 39.42% (95% CI: 30.47–48.38). Conclusion More than two-thirds of HIV-infected patients experienced dyslipidemia. Therefore, it's critical to regularly evaluate lipid alterations in HIV-infected patients in order to prevent the onset of atherosclerosis and other cardiovascular problems.https://doi.org/10.1186/s12879-023-08910-9DyslipidemiaSerum lipid abnormalityAntiretroviral therapyHIV/AIDSEthiopia |
| spellingShingle | Ousman Mohammed Ermiyas Alemayehu Habtu Debash Melaku Ashagrie Belete Alemu Gedefie Mihret Tilahun Hussen Ebrahim Daniel Gebretsadik Weldehanna Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis BMC Infectious Diseases Dyslipidemia Serum lipid abnormality Antiretroviral therapy HIV/AIDS Ethiopia |
| title | Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis |
| title_full | Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis |
| title_fullStr | Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis |
| title_full_unstemmed | Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis |
| title_short | Dyslipidemia among HIV-infected patients in Ethiopia: a systematic review and meta-analysis |
| title_sort | dyslipidemia among hiv infected patients in ethiopia a systematic review and meta analysis |
| topic | Dyslipidemia Serum lipid abnormality Antiretroviral therapy HIV/AIDS Ethiopia |
| url | https://doi.org/10.1186/s12879-023-08910-9 |
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